Steven M. Rowe, MD, MSPH

Pulm_Div_Rowe

Associate Professor of Medicine, Pediatric Pulmonary Medicine, and Physiology & Biophysics
 
Director, UAB Cystic Fibrosis Transition Clinic

Director, CFF Therapeutics Development Network
Center for CFTR Detection

Division of Pulmonary, Allergy & Critical Care Medicine
1530 3rd Avenue So, THT-422
University of Alabama at Birmingham
Birmingham, AL 35294

Board Certifications
2002, American Board of Internal Medicine
2002, American Board of Pediatric Medicine
2004, American Board of Internal Medicine, Pulmonary Diseases
2005, American Board of Internal Medicine, Critical Care Medicine

Medical School:  Vanderbilt University, 1998

Residency:  University of Alabama - Birmingham
Combined Internal Medicine and Pediatrics

Fellowship:  University of Alabama - Birmingham
Pulmonary & Critical Care Medicine

Contact Information

Campus Address:

 MCLM 768

Academic Office location:

 MCLM 768

Office Phone:

 (205) 934-9640

Office Fax (Academic):

 (205) 934-7593

TKC Clinic Phone:

 (205) 801-7545

TKC Clinic Fax:

 (205) 802-8231

Email Address:

  smrowe@uab.edu

Beeper #:

  7673

Office Assistant:  
Cheryl Owens
cowens@uab.edu 
Phone: (205) 934-9640 
Fax: (205) 934-7593

Brief Bio

Steven M. Rowe was born in Baton Rouge, LA in May 1972.  He received his BA degree from the University of Virginia in 1994, his medical degree from Vanderbilt University in 1998, and an MSPH from the University of Alabama at Birmingham in 2005.  He completed a combined Internal Medicine and Pediatrics internship and residency at the University of Alabama at Birmingham.  He also completed a combined Pulmonary and Critical Care Medicine and Pediatric Pulmonary fellowship at the University of Alabama at Birmingham.  In 2005, Dr. Rowe was appointed to the position of Instructor in Medicine in the Division of Pulmonary, Allergy and Critical Care Medicine, Pediatric Pulmonology, and Physiology & Biophysics at the University of Alabama at Birmingham.  He was promoted to Assistant Professor in 2006. Dr. Rowe's research affiliations are with the Cystic Fibrosis Research Center and Center for Biophysical Sciences and Engineering.  He currently serves as Director of the UAB CF Transition Clinic for adolescent young adults with CF, and Director of the CFF Therapeutics Development Network, Center for CFTR Detection.  Dr. Rowe is board certified in Internal Medicine, Pediatrics, Pulmonary Medicine and Critical Care Medicine.

Clinical Interests 

Dr. Rowe specializes in developing new treatments for cystic fibrosis, the most common autosomal recessive genetic disease, and the cause of severe pulmonary disease affecting children and young adults.  He maintains expertise in the design and conduct of clinical trials targeting the basic CF defect.  Dr. Rowe also has an interest in biomarkers of CF, including ion transport and the relation between mucus stasis and inflammation.  Dr. Rowe also specializes in the care of adolescent CF patients, where he directs the CF Transition Clinic, a collaborative project between the adult and pediatric CF care centers.

Academic & Research Interests

In concert with his clinic responsibilities and clinical research interests, Dr. Rowe maintains a research laboratory specializing in the mechanisms underlying cystic fibrosis, including agents intended to rescue the basic CF defect.  These studies routinely utilize cultured cells, human tissues, and mouse models.  Dr. Rowe directs the Center for CFTR Detection, a National Resource Center of the CF Therapeutics Development Network, responsible for development, interpretation, and quality assurance of in vivo assays of CFTR function.  Dr. Rowe is funded by the National Institutes of Health, the Cystic Fibrosis Foundation, and industry collaborators for these efforts.  He also directs an International Mucus Clearance Consortium, including basic and translational scientists charged with improving the mechanistic understanding of the mucus clearance defect in cystic fibrosis, and novel means to monitor the process.

Key Publications

Rowe SM, Miller S, Sorscher EJ.  "Mechanisms of Disease: Cystic Fibrosis."  New England Journal of Medicine, 2005; 352: 1992-2001.

Rowe SM, Varga K, Bebok ZB, Rab A, Bebok Z, Byram K, Li Y, Sorscher EJ, Clancy JP.  "Restoration of W1282X CFTR Activity by Enhanced Expression."  American Journal of Respiratory Cell and Molecular Biology, 2007; Sep;37(3):345-356.

Rowe SM, Accurso F, Clancy JP.  "Detection of Cystic Fibrosis Transmembrane Conductance Regulator Activity in Early-Phase Clinical Trials" Proceedings of the American Thoracic Society, 2007; Aug 1;4(4):387-398.

Rowe SM, Jackson PL, Liu G, Livraghi A, Solomon GM, McQuaid B, Noerager BD, Gaggar A, Clancy JP, O'Neal W, Abraham EA, Sorscher EJ, Blalock JE.  "Potential Role of High Mobility Group Box 1 in Cystic Fibrosis Pulmonary Disease". American Journal of Respiratory and Critical Care Medicine, 2008;178(8):822-31. (PMCID 2566793).

Rowe SM, Clancy JP. "Pharmaceuticals Targeting Nonsense Mutations in Genetic Diseases: Progress in Development". Invited Review, Biodrugs, 2009; 23(3):165-74. (PMCID 19627168).

 


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