Keith M. Wille, MD

Pulm_Div_Wille

Associate Professor of Medicine

Division of Pulmonary, Allergy & Critical Care Medicine
1530 3rd Avenue So, THT-422
University of Alabama at Birmingham
Birmingham, AL 35294

Board Certifications
1997, 2007, American Board of Internal Medicine
1999, 2009, American Board of Internal Medicine, Pulmonary Diseases
2000, 2010, American Board of Internal Medicine, Critical Care Medicine
2002, American Board Sleep Medicine

Medical School:   Louisiana State University, New Orleans, LA, 1990 - 1994 

internship:  University of Alabama - Birmingham, 1994 - 1995
Residency:  University of Alabama - Birmingham, 1995 - 1997
Fellowship:  University of Alabama - Birmingham, 1997 - 2000
Sleep Disorders Medicine:  University of Alabama - Birmingham, 1999-2000 

Contact Information

Campus Address:

 THT 422

Academic Office location:

 LHR 412

Office Phone:

 (205) 934-7970

Office Fax (Academic):

 (205) 975-0671

TKC Clinic Phone:

 (205) 801-7545

TKC Clinic Fax:

 (205) 802-8231

Email Address:

 mailto:This email address is being protected from spambots. You need JavaScript enabled to view it.

Beeper #:

 6892

Office Assistant:   
Linda Roberson                               
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Ph: (205) 934-7970 Fax: (205) 975-0671 

Brief Bio

Clinical Interests 

Lung Transplantation, Pulmonary Embolism

Academic & Research Interests

Key Publications

1. Wille KM, Moran J, Roundhill DM. Mercury and Methylmercury Complexes. Polyhedron 1990; 9(4):597-601.

2.     Gerald LB, Grad R, Turner-Henson A, Hains C, Tang S, Feinstein R, Wille KM, Erwin S, Bailey WC. Validition of a Multi-Stage Asthma Case Detection Procedure for Elementary School Children. Pediatrics 2004; 114 (4): 459-468.

3.     McGiffin DC, Alonso JE, Zorn GL, Kirklin JK, Young KR, Wille KM, Leon KJ, Hart K. Sternal Approximation for Bilateral Anterolateral Transsternal Thoracotomy for Lung Transplantation.  Ann Thor Surg 2005; 79: e19-20. 

4.     McGiffin DC, Zorn GL, Young KR, Kirklin JK, Leon KJ, Wille KM, Brown BS, Naftel DC, Hart K.  The Intensive Care Unit Oxygen Challenge should not be used for Donor Lung Function Decision Making.  J Heart Lung Transplant 2005; 24:1902-5.

5.     Pinderski L, Kirklin J, McGiffin D, Brown R, Naftel D, Young KR, Smith K, Bourge R, Tallaj J, Rayburn B, Benza R, Zorn G, Leon K, Wille K, Deierhoi M, George J.  Multi-Organ Transplantation: Is There A Protective Effect Against Acute and Chronic Rejection?  J Heart Lung Transplant 2005; 24: 1828-33.

6.     Tolwani AJ, Prendergast MB, Speer RR, Stofan BS, Wille KM.  A Practical Citrate CVVHDF Anticoagulation Protocol for Metabolic Control and High Solute Clearance.  Clin J Am Soc Neph 2006; 1 (1), 79-87.

7.     Tolwani A, Wheeler T, Wille K.  Sustained Low-Efficiency Dialysis.  Contrib. Nephrol. 2007; 156: 320-24.

8.     Covarrubias M, Ware L, Kawut S, DeAndrade J, Milstone A, Weinacker A, Orens J, Lama V, Wille K, Bellamy S, Shah C, Demissie E, Christie J.  Plasma Intracellular Adhesion Molecule-1 and Von Willibrand Factor in Primary Graft Dysfunction after Lung Transplantation. Am Journal Transplantation 2007; 7: 2573-8.

9.     Tolwani A, Campbell R, Lai R, Stofan B, Wille K.  Standard vs. High Dose CVVHDF for ICU-related Acute Renal Failure.  J Am Soc Nephrol. 2008 Jun;19 (6):1233-8.

10.   Fallon MB, Krowka MJ, Brown RS, Trotter JF, Zacks S, Roberts K.E., Shah V.H., Kaplowitz N, Forman L, Wille K, Kawut SM, Impact of Hepatopulmonary Syndrome on Quality of Life and Survival in Liver Transplant Candidates, Gastroenterology. 2008 Oct;135 (4):1168-75.

11.   Pisoni R, Wille K, Tolwani A.  The Epidemiology of Severe Acute Kidney Injury: From BEST to PICARD.  Nephron Clin Pract 2008; 109: c188-91.

12.   Wille K, Gaggar A, Hajari A, Barney J, Leon K, Boedefeld R, Smith K, Kirklin J, McGiffin  D, Young KR.  Bronchiolitis Obliterans Syndrome and Survival Following Lung Transplantation for Sarcoidosis.  Sarcoidosis, Vasculitis, and Diffuse Lung Diseases 2008; 25(2): 117-24.

13.   Hardison M, Galin FS, Calderon C, Wille KM, Jackson PL, Young KR, Blalock JE, Gaggar A.  The presence of a matrix-derived neutrophil chemoattractant seen in bronchiolitis obliterans syndrome after lung transplantation. Journal of Immunology 2009; 182 (7): 4423-31.

14.   Hoffman SA, Wang L, Shah CV, Ahya VN, Pochettino A, Olthoff K, Shaked A, Wille K, Lama VN, Milstone A, Ware LB, Orens J, Weinacker A, Demissie E, Bellamy S, Kawut SM, Hancock WW, Christie JD; Lung Transplant Outcomes Group. Plasma cytokines and chemokines in primary graft dysfunction post-lung transplantation. Am J Transplant. 2009 Feb;9(2):389-96. Epub 2008 Dec 15.

15.   Christie JD, Shah CV, Kawut SM, Mangalmurti N, Lederer DJ, Sonett JR, Ahya VN, Palmer SM, Wille K, Lama V, Shah PD, Shah A, Weinacker A, Deutschman CS, Kohl BA, Demissie E, Bellamy S, Ware LB; Lung Transplant Outcomes Group  Plasma levels of receptor for advanced glycation end products, blood transfusion, and risk of primary graft   dysfunction.  Am J Respir Crit Care Med. 2009 Nov 15;180(10):1010-5. Epub 2009 Aug 6.

16.   Fang A, Studer S, Kawut SM, Ahya VN, Lee J, Wille K, Lama V, Ware LB, Orens J, Weinacker A, Palmer SM, Crespo M, Lederer DJ, Deutschman CS, Kohl BA, Bellamy S,  Demissie E,  Christie JD: Elevated Pulmonary Artery Pressure is a Risk Factor for Primary Graft Dysfunction Following Lung Transplantation for Idiopathic Pulmonary Fibrosis. Chest. 2010 Sep 23. [Epub ahead of print] PMID: 20864607.

17.   Christie JD, Bellamy S, Ware LB, Lederer D, Hadjiliadis D, Lee J, Robinson N, Localio AR,Wille K, Lama V, Palmer S, Orens J, Weinacker A, Crespo M, Demissie E, Kimmel SE, Kawut SM.  Construct validity of the definition of primary graft dysfunction after lung transplantation. J Heart Lung Transplant. 2010 Nov; 29(11):1231-9.

18.  Shingarev R, Wille KM, Tolwani A.  Management of complications in  renal replacement therapy.  Seminars in Dialysis 2011; 24 (2): 164-8. 

19.  Lederer D, Kawut SM, Wickersham N, Winterbottom C, Bhorade S, Palmer S, Lee J, Diamond J, Wille KM , Weinacker A, Lama VN, Crespo M, Orens J, Sonett JR, Arcasoy SM, Ware LB, Christie JD4 for theLung Transplant Outcomes Group.  Obesity and Primary Graft Dysfunction after Lung Transplantation: The LTOG Obesity Study.  AJRCCM

Articles in Press. Published on July 28, 2011 as doi:10.1164/rccm.201104-0728OC.

20.  Sims MW, Beers MF, Ahya VN, Kawut SM, Sims KD, Lederer DJ, Palmer SM, Wille KLama VN, Shah PD, Orens JB, Bhorade S, Crespo M, Weinacker A, Demissie E, Bellamy SChristie JD, Ware LB; for the Lung Transplant Outcomes Group.  Effect of Single vs Bilateral Lung Transplantation on Plasma Surfactant Protein D Levels in Idiopathic Pulmonary Fibrosis.  Chest 2011; 140 (2): 489-96.

21.  Diamond JM, Kawut SM, Lederer DJ, Ahya VN, Kohl B, Sonett J, Palmer SM, Crespo M, Wille K, Lama VN, Shah PD, Orens J, Bhorade S, Weinacker A, Demissie E, Bellamy S, Christie JD, Ware LB; Lung Transplant Outcomes Group.  Elevated plasma clara cell secretory protein concentration is associated with high-grade primary graft dysfunction.  Am J Transplant. 2011 Mar;11(3):561-7.


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