Troy D. Randall, PhD received a new NIH U19 grant entitled, “Virus-Induced Cell Fate Decisions in Anti-Viral Immunity”. The study consists of four projects, supported by three cores. In Project 1, Dr. Troy Randall at UAB will determine how Tfh responses are controlled by IL-2 signaling and availability. In Project 2, Dr. Allan Zajac at UAB will determine how anti-viral CD8+ T cells responses are controlled by adhesion molecules and T cell clustering. In Project 3, Dr. Frances Lund at UAB will determine how anti-viral B cell responses are controlled by IFNgama signaling and availability. In Project 4, Dr. Nicole Baumgarth of UC Davis will determine how natural and induced anti-viral IgM responses are controlled. These projects will be facilitated by cores: (A) Administration and Biostatistics (Troy Randall, UAB); (B) Viral stocks and reagents (Frances Lund, UAB); and (C) Human immunology (Dr. Frances Eun-Hyung Lee, Emory). Importantly, all projects will be able to examine virus-specific B and T cells using tetramer reagents developed by Core B. In addition, although many of the mechanistic studies in each project will be performed using mouse models, the projects will also test key hypotheses in humans via interactions with the Human Immunology Core (Core C).