Jun Li MD, PhD

JunLi Updated 2013Instructor of Medicine

Division of Clinical Immunology and Rheumatology

Address:

Shelby Building, Suite 337
1825 University Boulevard
Birmingham, AL 35294-2182

Telephone: (205) 934-8909

Fax: (205) 996-6788

Email: junliuab@uab.edu


Education:


M.D.
Sun Yat-sen University, Medical School, Guangzhou, China 1997
Ph.D. (Physiology): University of Alabama at Birmingham, 2008
Postdoctoral Fellow: Department of Medicine, Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, 2012

Research Interests

 

Macrophages in pathogenesis of rheumatoid arthritis (RA) and development of novel macrophage target therapies in RA; Identification of novel markers (death receptor, et al) of M1 inflammatory macrophages in RA;


figure-1

Roles of fucosylation in regulation of macrophage differentiation, apoptosis, antigen presentation, cytoskeleton rearrangement, and how these are linked to pathogenesis of RA; efficacy and mechanisms of fucosylation inhibitors in the treatment of RA and other autoimmune diseases;

figure-2-2

Studies of inflammatory IRF5+ macrophages and GM-CSF+ CD4 T cell interaction in RA using synovial fluid and PBMC from RA subjects. 


Figure-3-2

Selected Publications


Li H, Wu Q, Li J, Yang P, Zhu Z, Luo B, Hsu H-C, and Mountz JD. 2013. Cutting Edge: Defective follicular exclusion of apoptotic antigens due to marginal zone macrophage defects in autoimmune BXD2 mice. J Immunol 190(9):4465-9. PMC3656168.


Wang JH, New JS, Xie S, Yang PA, Wu Q, Li J, Luo B, Ding Y, Druey KM, Hsu H-C, and Mountz JD. 2013. Extension of the germinal center stage of B-cell development promotes autoantibodies in BXD2 mice. Arthritis & Rheum 65(10), 2703-2712. (Supplementary Table)


Li J, Yang PA, Wu Q, Li, H, Ding Y, Hsu H-C, Spalding DM, and Mountz JD. 2013. Death receptor 5-targeted depletion of interleukin 23 producing macrophages, Th1, and Th1/17 associated with defective tyrosine phosphatase in mice and patients with rheumatoid arthritis. Arthritis & Rheum 65(10), 2594-2605. (Supplementary Table).


Ding Y, Li J, Wu Q, Yang P, Luo B, Xie S, Druey KM, Zajac AJ, Hsu H-C, and Mountz JD. 2013. IL-17RA is essential for optimal localization of follicular T helper cells in the germinal center light zone to promote autoantibody-producing B cells. J Immunol 191:1614-1624.


Li J
, Hsu H-C, and Mountz JD.  2012. Managing Macrophage in Rheumatoid Arthritis by Reform or Removal. Curr Rheumatol Rep. 14 (5):445-54. PMID: 22855296


Li J
, Hsu H-C, Yang P, Wu Q, Li H,  Edgington LE, Bogyo M, Kimberly RP, and Mountz JD.  2012. Treatment of Arthritis by Macrophage Depletion and Immunomodulation: Testing an Apoptosis-Mediated Therapy in a Humanized Death Receptor Mouse Model. Arthritis Rheum. 64(4):1098-109.  PMID: 22006294


Mountz JD, Li J, Hsu HC.  2012. Systemic autoimmunity caused by fas deficiency in macrophages: A new perspective on the first identified autoimmunity gene. Arthritis Rheum. 64(3):609-12. PMID: 22139895


Hsu H-C, Yang PA, Wu Q, Wang JH, Godwin J, Guentert T, Li J, Stockard CR, Le T, Chaplin DD, Grizzle WE, and Mountz, JD. 2011. Inhibition of the catalytic function of activation-induced cytidine deaminase (AICDA) promotes apoptosis of germinal center B cells. Arthritis Rheum. 63(7):2038-48. PMID: 21305519


Wang JH, Wu Q, Yang PA, Li H, Li J, Mountz JD and Hsu H-C.  2011. Type I IFN-dependent CD86high Marginal Zone-Precursor B Cells are Potent T-Cell Costimulators.  Arthritis Rheum.  63(4):1054-64.  PMID: 21225691


He D, Li H, Yusuf N, Elmets CA, Li J, Mountz JD, Xu H. 2010. IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells. J Immunol. 184(5):2281-8. PMID: 20118280  PMC3179912


Xie S, Li J, Wang JH, Wu Q, Yang P, Hsu H-C, Smythies LE, Mountz JD.  2010. IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16.  Journal of Immunology,  184(5):2289-96. PMID: 20139273   PMC2849003


Wang JH, Li J, Wu Q, Pawar RD, Xie S, Timares L, Raman C, Chaplin DD, Lu L, Mountz JD, Hsu HC.  2010. Marginal zone precursor B cells as cellular agents for Type I IFN-promoted antigen transport in autoimmunity.  Journal of Immunology, 184, 442 -451.  PMID: 19949066  PMC2830207


Chen J, Li J, Lim FC, Wu Q, Douek DC, Scott DK, Ravussin E, Hsu HC, Jazwinski SM, Mountz JD. 2010. Maintenance of naïve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3. Mech Ageing Dev. 131(1):29-37. PMID: 19941883   PMC2843505


Chen J, Wang J, Li J, Wu Q, Chu Lim F, Yang P, Hsu HC, Curiel DT, Mountz JD. 2008. Enhancement of cytotoxic T-lymphocyte response in aged mice by a novel treatment with recombinant AdIL-12 and wild-type adenovirus in rapid succession. Mol Ther. 16(8):1500-6. PMID: 18545221  PMC2575091


Chen J, Hsu HC, Zajac AJ, Wu Q, Yang P, Xu X, McPherson SA, Li J, Curiel DT, Mountz JD. 2006. In vivo analysis of adenovirus-specific cytotoxic T lymphocyte response in mice deficient in CD28, fas ligand, and perforin. Hum Gene Ther.17(6):669-82. PMID:16776575

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