Michael J. Fuller, PhD

Fuller 2013Assistant Professor of Medicine

Division of Clinical Immunology and Rheumatology

Address:

Shelby Building, Room 531
1825 University Boulevard
35294

Telephone: (205) 975-3324

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.


Education:

B.Sc. (Microbiology): Brigham Young University, Provo, UT  2000
Ph.D. (Microbiology): University of Alabama at Birmingham, Birmingham, AL  2005
Postdoctoral Fellow:  Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital, Columbus, OH  2011


Research Interests

The adaptive immune response plays a central role in mediating protection against infectious pathogens.  Under ideal circumstances, this results in the rapid control of infection and the development of memory that can protect against subsequent challenge from the same pathogen.  Not all infections, however, are rapidly resolved, and my interest is in understanding the differences in regulation of adaptive immunity that distinguish successful from unsuccessful responses to infectious disease.  My research has involved studying the roles of immune escape by pathogens, signaling through inhibitory co-receptors, duration of antigen exposure, breadth of adaptive immune responses, and the relative contributions of the CD4 and CD8 T cell responses, with the goal of identifying strategies by which unsuccessful adaptive immune responses may be improved.


Selected Publications

Khanolkar, A., Fuller, M.J., Zajac, A.J. 2002. T cell responses to viral infection: lessons from lymphocytic choriomeningitis virus. Immunolog Res 26: 309.


Fuller, M.J.
, Zajac, A.J.  2003.  Ablation of CD8 and CD4 T cell responses by high viral loads.  J Immunol 170: 477.


Hurez, V., Saparov, A., Tousson, A., Fuller, M.J., Kubo, T., Oliver, J., Weaver, B.T., Weaver, C.T.  2003.  Restricted clonal expression of IL-2 by naïve T cells reflects differential dynamic interactions with dendritic cells.  J Exp Med 198: 123.


Khanolkar, A., Fuller, M.J., Zajac, A.J.  2004.  CD4 T cell-dependent CD8 T cell maturation.  J Immunol 172: 2834.


Fuller, M.J.
, Khanolkar, A., Tebo, A.E., Zajac, A.J.  2004.  Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections.  J Immunol 172: 4204.


Fuller, M.J.
, Hildeman, D.A., Sabbaj, S., Gaddis, D.E., Tebo, A.E., Shang, L., Goepfert, P.A., Zajac, A.J.  2005.  Cutting edge: emergence of CD127high functionally competent memory T cells is compromised by high viral loads and inadequate T cell help.  J Immunol 174: 5926.


Tebo, A.E., Fuller, M.J., Gaddis, D.E., Kojima, K., Rehani, K., Zajac, A.J.  2005.  Rapid recruitment of virus-specific CD8 T cells restructures immunodominance during protective secondary responses.  J Virol 79: 12703.


Gaddis, D.E., Fuller, M.J., Zajac, A.J.  2006.  CD8 T-cell immunodominance, repertoire, and memory.  In Immunodominance – The Choice of the Immune System, J.A. Frelinger, editor.


Bowen, D.G., Shoukry, N.H., Grakoui, A., Fuller, M.J., Cawthon, A.G., Dong, C., Hasselschwert, D.L., Brasky, K.M., Freeman, G.J., Seth, N.P., Wucherpfennig, K.W., Houghton, M., Walker, C.M.  2008.  Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection.  J Virol 82: 5109.


Fuller, M.J.
, Shoukry, N.H., Gushima, T., Bowen, D.G., Callendret, B., Campbell, K.J., Hasselschwert, D.L., Hughes, A.L., Walker, C.M.  2010.  Selection-driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection.  Hepatology 51: 378.

 

Fuller MJ, Callendret B, Zhu B, Freeman GJ, Hasselschwert DL, Satterfield W, Sharpe AH, Dustin LB, Rice CM, Grakoui A, Ahmed R, Walker CM. 2013.Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1).Proc Natl Acad Sci U S A. 110(37):15001-6. PMID:23980172

 

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