Laurence A. Bradley, PhD

BradleyProfessor of Medicine

Address: 

Shelby Building Room 177A
1825 University Blulevard
35294-2182

Telephone:(205) 934-8550
Fax:(205) 934-1564
Email: braddog@uab.edu

 

Education

BA (Psychology), Vanderbilt University, 1971
PhD (Clinical Psychology), Vanderbilt University, 1975
Clinical Internship, Duke University Medical Center, 1975-1976

 

Research Description

 
Dr. Bradley's research focuses on the interactions among biological and psychosocial factors associated with abnormal pain sensitivity in persons with osteoarthritis (OA) of the knee, and other chronic painful disorders. Several studies are ongoing:(1) In collaboration with investigators from the University of Florida, the project goal is to characterize ethnic differences in experimental pain sensitivity, endogenous pain inhibition, clinical pain, and pain-related disability in older African-Americans and non-Hispanic whites with and without knee OA and determine whether these measures of pain sensitivity/pain inhibition along with biological, psychological, and socio-cultural variables mediate ethnic group differences in clinical pain and pain-related disability; (2) a related project examines the extent to which differences in pain responses between African-American and white patients with knee OA are mediated by group differences in neurosteroid hormones (3) In collaboration with investigators from the UAB Division of Preventive Medicine, the project goal is to test the efficacy of a cognitive-behavioral intervention, delivered by trained community health workers, in helping persons in rural Alabama with knee OA and diabetes to better manage their pain; and (4) In collaboration with colleagues in the     Multicenter Osteoarthritis Trial (MOST), the project goal is to examine alterations in pain sensitivity using standardized, quantifiable sensory testing to better understand the neurological mechanisms that sustain or magnify painful knee OA symptoms as well as the contribution of pain to functional loss and the long term trajectory of this chronic disease. Future projects include an examination of the relationship between polysomnography measures of sleep and experimental as well as clinical pain  to better understand the biological, psychological, and socio-cultural variables that mediate ethnic group differences in both sleep and pain.

 

Selected Publications

 

King CD, Sibille KT, Goodin BR, Cruz-Almeida Y, Glover TL, Bartley E, Riley JL,Herbert MS, Sotolongo A, Schmidt J, Fessler BJ, Redden DT, Staud R, Bradley LA, Fillingim RB. 2013. Experimental pain sensitivity differs as a function of clinical pain severity in symptomatic knee osteoarthritis. Osteoarthritis Cartilage 21: 1243-1252 PMCID: PMC3831366

Goodin BR, Pham Q, Glover T, King C, Sibille KT, Cruz-Almeida Y, Staud R, Redden D, Bradley LA, Fillingim R. 2013. Perceived racial discrimination, but not mistrust of medical researchers, predicts the heat pain tolerance of African Americans with symptomatic knee osteoarthritis. Health Psychology, 32: 1117-1126. PMCID: PMC3943939

Goodin BR, Glover TL, Sotolongo A, King CD, Sibille KT, Herbert MS, Cruz-Almeida Y, Sanden SH, Staud R, Redden DT, Bradley LA, Fillingim RB. 2013. The association of greater dispositional optimism with less endogenous pain facilitation is indirectly transmitted through lower levels of pain catastrophizing. J Pain. 14(2):126-35. PMCID: PMC3592576

Herbert MS, Varley AL, Andreae SJ, Goodin BR, Bradley LA, Safford MM. 2013. The association of pain and HbA1c in a predominantly black sample of community-dwelling adults with diabetes: a cross-sectional analysis. Diabetic Med 30: 1466-1471 PMCID: PMC3935766

Cruz-Almeida Y, King CD, Goodin BR, Sibille KT, Glover TL, Riley JL, Sotolongo A, Herbert MS, Schmidt J, Fessler BJ, Redden DT, Staud R, Bradley LA, Fillingim RB. 2013. Psychological profiles and pain characteristics of older adults with knee osteoarthritis. Arthritis Rheum (Arthritis Care Res)  65: 1786-1794 PMCID: PMC3922880

Wise BL, Niu J, Zhang Y, Felson DT, Bradley LA, Segal N, Keysor J, Nevitt M, Lane NE. 2013. The association of parity with osteoarthritis and knee replacement in the Multicenter Osteoarthritis Study. Osteoarthritis Cartilage  21: 1849-1854 PMCID: PMC3855897

Riley III JL, Cruz-Almeida Y, Glover TL, King CD, Goodin BR, Sibille KT, Bartley EJ, Herbert MS, Sotolongo A, Fessler BJ, Redden DT, Staud R, Bradley LA, Fillingim RB. 2014. Age and race effects on pain sensitivity and modulation among middle-aged and older adults. J Pain, 2014; 15: 272–282 PMCID: PMC4005289

Cruz-Almeida Y, Sibille KT, Goodin BR, Petrov ME, Bartley EJ, Riley JL, King CD, Glover TL, Sotolongo A, Herbert MS, Schmidt J, Fessler BJ, Staud R, Redden D, Bradley LA, Fillingim RB. Racial and ethnic differences in older adults with knee osteoarthritis. Arthritis Rheum  66:1800-1810 PMID: 24729357

Ruiter Petrov ME, Lichstein KL, Huisingh CE, Bradley LA. 2014. Predictors of adherence to a brief behavioral insomnia intervention: daily process analysis. Behav Ther  45: 430-442 PMID: 24680236

Herbert MS, Goodin BR, Pero ST, Schmidt JK, Sotolongo A, Bulls HW, Glover TL, King CD, Sibille KT, Cruz-Almeida Y, Staud R, Fessler BJ, Bradley LA, Fillingim RB. 2014. Pain hypervigilance is associated with greater clinical pain severity and enhanced experimental pain sensitivity among adults with symptomatic knee osteoarthritis. Ann Behav Med 48: 50-60 PMID: 24352850

Neogi T, Frey-Law L, Scholz J, Niu J, Arendt-Nielsen L, Woolf C, Nevitt M, Bradley L, Felson DT, for the Multicenter Osteoarthritis (MOST) Study. Sensitivity and sensitisation in relation to pain severity in knee osteoarthritis: trait or state? Ann Rheum Dis in press, 2014 PMID: 24351516

Goodin BR, Bulls HW, Herbert MS, Schmidt J, King CD, Glover TL, Sotolongo A, Sibille KT, Cruz-Almeida Y, Staud R, Fessler BJ, Redden DT, Bradley LA, Fillingim RB. Temporal summation of pain as a prospective predictor of clinical pain severity in adults aged 45 years and older with knee osteoarthritis: ethnic differences. Psychosom Med in press, 2014 PMCID: PMC4066647

Petrov ME, Sawyer P, Kennedy R, Bradley LA, Allman RM. Benzodiazepine (BZD)use in community-dwelling older adults: Longitudinal associations with mobility,functioning, and pain. Arch Gerontol Geriatr in press, 2014 PMID: 24880195

Glass N, Segal NA, Sluka KA, Torner JC, Nevitt MC, Felson DT, Bradley LA, Neogi T, Lewis CE, Frey-Law LA. Examining sex differences in knee pain: The Multicenter Osteoarthritis Study. Osteoarthritis Cartilage in press, 2014 PMID: 24999111

 

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