Schroeder, Harry W., Jr., MD, PhD

Schroeder 2012 2John R Irby Research Scholar

Professor of Medicine, Microbiology, and Genetics

Division Clinical Immunology & Rheumatology

Director, UAB Program in Immunology
Director, Immunologic Diseases & Basic Immunology Training Program

 

Address:

Shelby Building, Room 405
1825 University Boulevard, 35294-2182

Telephone: 205-934-1522
Email: hschroed@uab.edu

 

Associate: Dr. Ada Elgavish
Shelby Building, Room 415
1825 University Blvd.
Birmingham, AL35294-2182
Telephone:205-934-6547
Email: aelgavis@uab.edu

 

Clinical Coordinator: Marsha Brand, RN
Shelby Building, Room 412
1825 University Blvd.
Birmingham, AL35294-2182
Telephone: 205-934-1522
Email: mgbrand@uab.edu

 

Education

BS (Chemistry), Texas A&M University, College Station, TX
MD, Baylor College of Medicine, Houston, TX
PhD (Cell Biology), Baylor College of Medicine, Houston, TX

 

Research Interests

B cell and repertoire development.   Although at first glance the power of the mechanisms used to diversify the B- and T-cell antigen receptors appear to generate repertoires of random diversity, closer examination reveals striking constraints that are preserved across evolution.  The implication is that violation of these constraint programs could lead to immune dysfunction, and thus to disease.  My group has used Cre-loxP gene targeting to generate mice wherein the DH locus has been altered for force expression of polyclonal antibody repertoires that lie outside normal constraints.  In these mice, B cell numbers are reduced, responses to T-independent antigens decline in a co-dominant manner, and responses to T-dependent antigens and autoantigens are affected in a dominant manner.  The mechanisms that underlie these alterations and the contribution of a failure to properly regulate the repertoire are a major focus of the laboratory. 

Genetics of primary immune deficiency diseases
. A second focus in the laboratory is the use of classic reverse genetics techniques to study human immune deficiency disorders.

 

Publications

Click here for a more complete list of publications in PubMed. Below are a few selected papers.


Link JM, Larson JE, Schroeder HW Jr. 2005. Despite extensive similarity in germline DH and JH sequence, the adult Rhesus macaque CDR-H3 repertoire differs from human. Mol Immunol 42:943-955. PMID: 15829286


Ivanov II, Schelonka RL, Zhuang Y, Gartland GL, Zemlin M, Schroeder HW Jr. 2005. Development of the expressed immunoglobulin CDR-H3 repertoire is marked by focusing of constraints in length, amino acid utilization, and charge that are first established in early B cell progenitors. J Immunol 174:7773-7780. PMID: 15944280


Schelonka RL, Ivanov II, Jung D, Ippolito GC, Nitschke L, Zhuang Y, Gartland GL, Pelkonen J, Alt F, Rajewsky K, Schroeder HW Jr. 2005. A single DH gene segment is sufficient for B cell development and immune function. J Immunol 175:6624-6632. PMID: 16272317


Hsu H-C, Scot DK, Zhang P, Zhou J, Yang PA, Wu Q, Schroeder HW Jr, Gerald LB, Ravussin E, Jazwinski MS, Mountz JD. 2006. CD8 T-cell immune phenotype of successful aging. Mech Aging Develop 127:231-239.  PMID: 16313945


Johnston DT, Mehaffey G, Thomas J, Young KR Jr, Wiener H, Li J, Li J, Go RCP, Schroeder HW Jr. 2006. Increased frequency of HLA *B44 in recurrent sinopulmonary infections (RESPI). Clin Immunol 119:346-350. PMID: 16542878


Ippolito, GC, Schelonka RL, Zemlin M, Ivanov I, Kobayashi R, Zemlin C, Gartland L, Nitschke L, Pelkonnen J, Fujihashi K, Rajewsky K, Schroeder HW Jr. 2006. Forced use of an immunoglobulin DH encoding positively charged amino acids impairs B cell development and function. J Exp Med 203:1567-157. PMID: 16754718


Johnston DT, Schroeder HW Jr. 2007. B-cell numbers in the blood of patients with non-HLA*B8 or non-HLA*B44 common variable immunodeficiency. Ann Allergy Asthma Immunol. 98(2):163-167. PMID: 17304884


Schelonka RL, Tanner J, Zhuang Y, Gartland GL, Zemlin M, Schroeder HW Jr. 2007. Categorical selection of the antibody repertoire in splenic B cells. Eur J Immunol 37(4):1010-1021. PMID: 17345580


Li J, Cowden LG, King JD, Briles DA, Schroeder HW Jr, Stevens AB, Perry RT, Chen Z, Simmons MS, Wiender HW, Tiwari H, Harrell LE, Go RCP. 2007. Effects of chronic stress and interleukin-10 polymorphisms on antibody response to tetanus vaccine in family caregivers of patients with Alzheimer’s Disease. Psychosom Med 69:551-559. PMID: 17634568


Nguyen HH, Zemlin M, Vu HL, Ivanov II, Andrasi J, Zemlin C, Schelonka RL, Schroeder HW Jr<, Mestecky 2007. Heterosubtypic immunity to influenza A virus infection requires a properly diversified antibody repertoire.  J Virol 81:9331-9338.  PMID: 17567700


Schelonka RL, Zemlin M, Kobayashi R, Ippolito GC, Zhuang Y, Gartland GL, Fujihashi K, Rajewsky K, Schroeder HW Jr. 2008. Preferential use of DH reading frame 2 alters B cell development and antigen-specific antibody production. J Immunol 181(12): 8409-8415. PMID: 19050258.


Zemlin M, Schelonka RL, Ippolito GC, Zemlin C, Zhuang Y, Gartland GL, Nitschke L, Pelkonen J, Rajewsky K, Schroeder HW Jr. 2008. Regulation of repertoire development through genetic control of DH reading frame preference. J Immunol 181(12): 8416-8424.  PMID: 19072309


Kerzel S, Wagner J, Rogosch T, Yildirim AO, Sikula L, Fehrenbach H, Garn H, Maier RF, Schroeder HW Jr, Zemlin M. 2009. Composition of the immunoglobulin classic antigen-binding site regulates allergic airway inflammation in a murine model of experimental asthma. Clin Exp Allergy. 39(4):455-7. PMID: 19220320


Waldrep ML, Zhuang Y, Schroeder HW Jr. 2010. Analysis of TACI mutations in CVID & RESPI patients who have inherited HLA B*44 or HLA*B8. BMC Med Genet. 10:100.PMID: 19775471


Vale AM, Schroeder HW Jr, Zemlin M. 2010. Clinical consequences of defects in B-cell development. J Allergy Clin Immunol. 125(4):778-87.PMID: 20371392


Schroeder HW Jr, Cavacini L. 2010. Structure and function of immunoglobulins. J Allergy Clin Immunol. 125(2 Suppl 2):S41-52.PMID: 20176268


Wang C, Sanders CM, Yang Q, Schroeder HW Jr, Wang E, Babrzadeh F, Gharizadeh B, Myers RM, Hudson JR Jr, Davis RW, Han J. 2010. High throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets. Proc Natl Acad Sci U S A.107(4):1518-23 PMID: 20080641


Schroeder HW Jr, Cavacini L. 2010. Structure and function of immunoglobulins. J Allergy Clin Immunol. 125(2 Suppl 2):S41-52. PMID: 20176268


Vale AM, Schroeder HW Jr. 2010. Clinical consequences of defects in B-cell development.J Allergy Clin Immunol. 125(4):778-87. PMID: 20371392


Schroeder HW Jr, Zemlin M, Khass M, Nguyen HH, Schelonka RL. 2010. Genetic control of DH reading frame and its effect on B-cell development and antigen-specifc antibody production. Crit Rev Immunol. 30(4):327-44. PMID: 20666706


Schelonka RL, Szymanska E, Vale AM, Zhuang Y, Gartland GL, Schroeder HW Jr. 2010.  DH and JH usage in murine fetal liver mirrors that of human fetal liver. Immunogenetics. 62(10):653-66. PMID: 20714894


Vale AM, Tanner JM, Schelonka RL, Zhuang Y, Zemlin M, Gartland GL, Schroeder HW Jr. 2010. The peritoneal cavity B-2 antibody repertoire appears to reflect many of the same selective pressures that shape the B-1a and B-1b repertoires.J Immunol. 185(10):6085-95. PMID: 20956345


Schelonka RL, Ivanov II, Vale AM, Szymanska E, Zemlin M, Gartland GL, Schroeder HW Jr. 2010. The CDR-H3 repertoire from TdT-deficient adult bone marrow is a close, but not exact, homologue of the CDR-H3 repertoire from perinatal liver. J Immunol. 185(10):6075-84. PMID: 20956348


Schelonka RL, Ivanov II, Vale AM, Dimmitt RA, Khaled M, Schroeder HW Jr. 2011. Absence of N addition facilitates B cell development, but impairs immune responses. Immunogenetics. 63(9):599-609. PMID:21660592


Mahmoud TI, Schroeder HW Jr, Kearney JF. 2011. Limiting CDR-H3 diversity abrogates the antibody response to the bacterial polysaccharide α 1→3 dextran.J. Immunol. 187(2):879-86. . PMID:21677133


Kerzel S, Rogosch T, Wagner J, Preisser K, Yildirim AÖ, Fehrenbach H, Garn H, Maier RF, Schroeder HW Jr, Zemlin M. 2011. A single DH gene segment is sufficient for the establishment of an asthma phenotype in a murine model of allergic airway inflammation. Int Arch Allergy Immunol.156(3):247-58. PMID:21720170


Vale AM, Foote JB, Granato A, Zhuang Y, Pereira RM, Lopes UG, Bellio M, Burrows PD, Schroeder HW Jr, Nobrega A. 2012. A rapid and quantitative method for the evaluation of V gene usage, specificities and the clonal size of B cell repertoires. J Immunol Methods. 376(1-2):143-9. PMID:22226792


Westerink MA, Schroeder HW Jr, Nahm MH. 2012. Immune Responses to pneumococcal vaccines in children and adults: Rationale for age-specific vaccination. Aging Dis. 3(1):51-67. PMID:22500271


Lange H, Hecht O, Zemlin M, Trad A, Tanasa RI, Schroeder HW Jr, Lemke H. 2012. Immunoglobulin class switching appears to be regulated by B-cell antigen receptor-specific T-cell action. Eur J Immunol. 42(4):1016-29. PMID:22531925


Schroeder HW Jr, Dougherty CJ. 2012. Review of intravenous immunoglobulin replacement therapy trials for primary humoral immunodeficiency patients. Infection. 40(6):601-11 PMID:22968971


Khass M, Buckley K, Kapoor P, Schelonka RL, Watkins LS, Zhuang Y, Schroeder HW Jr. 2013. Recirculating bone marrow B cells in C57BL/6 mice are more tolerant of highly hydrophobic and highly charged CDR-H3s than those in BALB/c mice. Eur J Immunol. 43(3):629-40. PMID:23225217


Vale AM, Kapoor P, Skibinski GA, Elgavish A, Mahmoud TI, Zemlin C, Zemlin M, Burrows PD, Nobrega A, Kearney JF, Briles DE, Schroeder HW Jr. 2013. The link between antibodies to OxLDL and natural protection against pneumococci depends on D(H) gene conservation. J Exp Med. 2013 May 6;210(5):875-90. PMID:23589567

 

Recent Invited Reviews and Textbook Chapters

Torres RM, Imboden J, Schroeder HW Jr. 2008. Antigen receptor genes, gene products, and co-receptors. In:Clinical Immunology: Principles and Practices, 3nd edition, eds. Rich R, Fleisher TA, Shearer WT, Schroeder HW Jr, Frew AJ, Weyand CM. Elsevier, London.


Berek C, Radbruch A, Schroeder HW Jr 2008. B cell development and differentiation. In: Clinical Immunology: Principles and Practices, 3nd edition, eds. Rich R, Fleisher TA, Shearer WT, Schroeder HW Jr, Frew AJ, Weyand CM.  Elsevier, London.


Schroeder HW Jr. 2008. Primary antibody deficiencies.  In:Clinical Immunology: Principles and Practices, 3nd edition, eds. Rich R, Fleisher TA, Shearer WT, Schroeder HW Jr, Frew AJ, Weyand CM.  Elsevier, London.


Schroeder HW Jr, Wald D, Greenspan NS. 2008. Immunoglobulins: Structure and Function. In: Fundamental Immunology, edition, eds.


Cooper MD, Schroeder HW Jr. 2008. Primary immune deficiency diseases. In: Harrison’s Principles of Internal Medicine, 17th edition.

 

Books

Rich RR, Fleisher TA, Shearer WT, Kotzin B, Schroeder HW Jr.Clinical Immunology: Principles and Practices, 2nd edition, Harcourt International, London.


Rich RR, Fleisher TA, Shearer WT, Schroeder HW Jr, Frew AJ, Weyand CM. Clinical Immunology: Principles and Practices, 3nd edition, Elsevier, London.


Robert R. Rich, Thomas A Fleisher, William T. Shearer, Harry Schroeder, Anthony J. Frew, Cornelia M. Weyand. Clinical Immunology: Principles and Practice, 4th Edition, Elsevier, London.

 

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