Singh---2012Professor of Medicine and Epidemiology
Endowed Professor, Musculoskeletal Outcomes Research
2016 ACR Henry Kunkel Young Investigator Award



Faculty Office Tower, room 805B
Birmingham, AL 35294-0000

Telephone: (205) 934-0315
Fax: (205) 996-9685




Bachelor of Medicine and Bachelor of Surgery (MBBS), University College of Medical Sciences, New Delhi, India, 1988-1993
Master of Public Health (Epidemiology), University of Minnesota, Minneapolis, MN, 2001-2003
Residency (Psychiatry), All India Institute of Medical Sciences (AIIMS), New Delhi, India , 1994
Residency (Internal Medicine), State University of New York (SUNY), Syracuse, NY, 1995-1998
Fellowship (Rheumatology), Washington University School of Medicine & Barnes Jewish Hospital, St. Louis, MO, 1998-2001


Research Interests

Dr. Singh is involved in performing Cochrane reviews and network meta-analysis of randomized controlled trials of biologics for rheumatoid arthritis and other therapies for rheuamtic diseases. He is also conducting studies of patient-reported outcomes in patients with various forms of arthritis, in particular osteoarthritis, joint replacement and gout. He is performing studies of comparative effectiveness of treatments used in patients with gout and joint replacement.



Click here for a more complete list of publications. Below are a few selected papers.

Singh JA, Yu S. 2017. Are allopurinol dose and duration of use nephroprotective in the elderly? A Medicare claims study of allopurinol use and incident renal failure. Ann Rheum Dis. 76(1):133-139. PMID: 27296322

Singh JA, Hossain A, Tanjong Ghogomu E, et al. 2017. Biologics or tofacitinib for people with rheumatoid arthritis unsuccessfully treated with biologics: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 3:CD012591. PMID: 28282491.

Singh JA, Hossain A, Tanjong Ghogomu E, Mudano AS, Tugwell P, Wells GA. 2016. Biologic or tofacitinib monotherapy for rheumatoid arthritis in people with traditional disease-modifying anti-rheumatic drug (DMARD) failure: a Cochrane Systematic Review and network meta-analysis (NMA). Cochrane Database Syst Rev. 11:CD012437. PMID: 27855242

Singh JA, Hossain A, Tanjong Ghogomu E, et al. 2016. Biologics or tofacitinib for rheumatoid arthritis in incomplete responders to methotrexate or other traditional disease-modifying anti-rheumatic drugs: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 5:CD012183. PMID: 27175934.

Singh JA, Saag KG, Bridges SL, Jr., et al. 2016. 2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. Arthritis Rheumatol. 68(1):1-26. PMID: 26545940.

Singh JA, Hossain A, Kotb A, et al. 2016. Treatments for Lupus Nephritis: A Systematic Review and Network Metaanalysis. J Rheumatol. PMID: 27585688.

Singh JA. 2015. When gout goes to the heart: does gout equal a cardiovascular disease risk factor? Ann Rheum Dis. 74(4):631-634. PMID: 25603830.

Wang H, et al. 2014. Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.  Lancet. 384: 957-979 . PMID: 24797572; PMCID: PMC4165626

Singh JA, Taylor WJ, Dalbeth N, Simon LS, Sundy J, Grainger R, Alten R, March L, Strand V, Wells G, Khanna D, McQueen F, Schlesinger N, Boonen A, Boers M, Saag KG, Schumacher HR, Edwards NL. 2014. OMERACT endorsement of measures of outcome for studies of acute gout. J Rheumatol. 41(3):569-573. PMID: 24334651; PMCID: PMC4162875

Singh JA, Ramachandran R. 2014. Hospital Volume Predicts Outcomes and Complications after Total Shoulder Arthroplasty in the United States. Arthritis Care Res (Hoboken).  PMID: 25370499.

Singh JA, Luo R, Landon GC, Suarez-Almazor M. 2014. Reliability and clinically important improvement thresholds for osteoarthritis pain and function scales: a multicenter study. J Rheumatol. 41(3):509-515. PMID: 24429183; PMCID: PMC3943561.

Singh JA, Lu X, Rosenthal GE, Ibrahim S, Cram P. 2013. Racial disparities in knee and hip total joint arthroplasty: an 18-year analysis of national medicare data. Ann Rheum Dis. 2013 Sep 18. PMID:24047869

Mudano AS, Gary LC, Oliveira AL, Melton M, Wright NC, Curtis JR, Delzell E, Harrington TM, Kilgore ML, Lewis CE, Singh JA, Warriner AH, Pace WD, Saag KG. 2013. Using tablet computers compared to interactive voice response to improve subject recruitment in osteoporosis pragmatic clinical trials: feasibility, satisfaction, and sample size. Patient Prefer Adherence. 7:517-23. PMID:23807841

Singh JA, Hawn M, Campagna EJ, Henderson WG, Richman J, Houston TK. 2013. Mediation of smoking-associated postoperative mortality by perioperative complications in veterans undergoing elective surgery: data from Veterans Affairs Surgical Quality Improvement Program (VASQIP)--a cohort study. BMJ Open. 2013 Apr 18;3(4). PMID:23604347

Saag KG, Mohr PE, Esmail L, Mudano AS, Wright N, Beukelman T, Curtis JR, Cutter G, Delzell E, Gary LC, Harrington TM, Karkare S, Kilgore ML, Lewis CE, Moloney R, Oliveira A, Singh JA, Warriner A, Zhang J, Berger M, Cummings SR, Pace W, Solomon DH, Wallace R, Tunis SR. 2012. Improving the efficiency and effectiveness of pragmatic clinical trials in older adults in the United States. Contemp Clin Trials. 33(6):1211-6. PMID:22796098

Singh JA, Lewallen DG. 2012. Ninety-day mortality in patients undergoing elective total hip or total knee arthroplasty. J Arthroplasty. 27(8):1417-1422.e1. PMID:22554727

Singh JA, Furst DE, Bharat A, Curtis JR, Kavanaugh AF, Kremer JM, Moreland LW, O'Dell J, Winthrop KL, Beukelman T, Bridges SL Jr, Chatham WW, Paulus HE, Suarez-Almazor M, Bombardier C, Dougados M, Khanna D, King CM, Leong AL, Matteson EL, Schousboe JT, Moynihan E, Kolba KS, Jain A, Volkmann ER, Agrawal H, Bae S, Mudano AS, Patkar NM, Saag KG. 2012. 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care Res (Hoboken). 64(5):625-39. PMID:22473917

Navarro-Millán I, Singh JA, Curtis JR. 2012.Systematic review of tocilizumab for rheumatoid arthritis: a new biologic agent targeting the interleukin-6 receptor. Clin Ther. 2012 Apr;34(4):788-802.e3. PMID:22444783

Singh JA. 2011 Epidemiology of knee and hip arthroplasty: a systematic review. Open Orthop J. 5:80-5. PMID: 21584277

Kalore NV, Gioe TJ, Singh JA. 2011. Diagnosis and management of infected total knee arthroplasty.Open Orthop J. 5:86-91. PMID: 21584272

Singh JA. 2011. Editorial: current concepts in arthroplasty. Open Orthop J. 5:78-9. PMID: 21584271

Mertens MT, Singh JA. 2011. Biomarkers in arthroplasty: a systematic review. Open Orthop J. 2011 5:92-105. PMID: 21584201

Johnson MR, Singh JA, Stewart T, Gioe TJ. 2011. Patient understanding and satisfaction in informed consent for total knee arthroplasty: A randomized study. Arthritis Care Res (Hoboken).63(7):1048-54. PMID: 21485018

Khanna D, Sarkin AJ, Khanna PP, Shieh MM, Kavanaugh AF, Terkeltaub RA, Lee SJ, Singh JA, Hirsch JD. 2011. Minimally important differences of the gout impact scale in a randomized controlled trial.Rheumatology (Oxford). 2011 Mar 3. [Epub ahead of print]PMID: 21372003

Singh JA, Wells GA, Christensen R, Tanjong Ghogomu E, Maxwell L, Macdonald JK, Filippini G, Skoetz N, Francis D, Lopes LC, Guyatt GH, Schmitt J, La Mantia L, Weberschock T, Roos JF, Siebert H, Hershan S, Lunn MP, Tugwell P, Buchbinder R. 2011. Adverse effects of biologics: a network meta-analysis and Cochrane overview. Cochrane Database Syst Rev. 2011 Feb 16;2:CD008794. PMID: 21328309

Singh JA. 2010. Botulinum toxin therapy for osteoarticular pain: an evidence-based review. Ther Adv Musculoskelet Dis. 2(2):105-118. PMID: 21304830

Singh JA, Reddy SG, Kundukulam J. 2011. Risk factors for gout and prevention: a systematic review of the literature. Curr Opin Rheumatol. 23(2):192-202. PMID: 21285714 

Singh JA, Fitzgerald PM. 2011. Botulinum toxin for shoulder pain: a cochrane systematic review. J Rheumatol. 38(3):409-18. PMID: 21285169

Singh JA, Sperling J, Buchbinder R, McMaken K. 2011. Surgery for shoulder osteoarthritis: a cochrane systematic review. J Rheumatol. 38(4):598-605. PMID: 21239751

Singh JA, Christensen R, Wells GA, Suarez-Almazor ME, Buchbinder R, Lopez-Olivo MA, Ghogomu ET, Tugwell P. 2010. Biologics for rheumatoid arthritis: an overview of Cochrane reviews. Sao Paulo Med J. 128(5):309-10. PMID: 21181074

Singh JA, Lewallen DG. 2010. Predictors of activity limitation and dependence on walking aids after primary total hip arthroplasty. J Am Geriatr Soc. 58(12):2387-93. PMID: 21143444

Ramiro S, Machado P, Singh JA, Landewé RB, da Silva JA. 2010. Applying science in practice: the optimization of biological therapy in rheumatoid arthritis. Arthritis Res Ther. 12(6):220. PMID: 21067530

Singh JA. 2010. Advances in gout: some answers, more questions. Arthritis Res Ther. 12(5):136. PMID:20959031

Barsevick A, Frost M, Zwinderman A, Hall P, Halyard M; GENEQOL Consortium. 2010. I'm so tired: biological and genetic mechanisms of cancer-related fatigue. Qual Life Res. 19(10):1419-27. PMID: 20953908

Singh JA, Beg S, Lopez-Olivo MA. 2010. Tocilizumab for rheumatoid arthritis. Cochrane Database Syst Rev. 7:CD008331. PMID: 20614469

Singh JA, Lewallen D. 2010. Predictors of pain and use of pain medications following primary Total Hip Arthroplasty (THA): 5,707 THAs at 2-years and 3,289 THAs at 5-years.BMC Musculoskelet Disord. 11:90.PMID: 20462458

Singh JA, Noorbaloochi S, Singh G. 2010. Golimumab for rheumatoid arthritis: a systematic review.J Rheumatol. 37(6):1096-104.PMID: 20436075

Boon AJ, Smith J, Dahm DL, Sorenson EJ, Larson DR, Fitz-Gibbon PD, Dykstra DD, Singh JA. 2010. Efficacy of intra-articular botulinum toxin type A in painful knee osteoarthritis: a pilot study. PM R. 2(4):268-76.PMID: 20430328

Singh JA, Gabriel SE, Lewallen DG. 2010. Higher Body Mass Index Is Not Associated With Worse Pain Outcomes After Primary or Revision Total Knee Arthroplasty.J Arthroplasty. 26(3):366-374 PMID: 20413245

Anderson A, Singh JA. 2010. Pegloticase for chronic gout. Cochrane Database Syst Rev. 3:CD008335 PMID: 20238366

Singh JA, Alpert MD, Kerr G. 2010. A national survey of veterans affairs rheumatologists for relevance of quality of care indicators for gout management. Arthritis Care Res (Hoboken). [Epub ahead of print] PMID: 20235197

Singh JA, Sloan JA, Johanson NA. 2010. Challenges with health-related quality of life assessment in arthroplasty patients: problems and solutions. J Am Acad Orthop Surg. 18(2):72-82. PMID: 20118324

Strand V, Singh JA. 2010. Newer biological agents in rheumatoid arthritis: impact on health-related quality of life and productivity.Drugs. 70(2):121-45. PMID: 20108988

Singh JA, Noorbaloochi S, Singh G. 2010. Golimumab for rheumatoid arthritis. Cochrane Database Syst Rev. (1):CD008341. PMID: 20091667

Singh JA, Christensen R, Wells GA, Suarez-Almazor ME, Buchbinder R, Lopez-Olivo MA, Ghogomu ET, Tugwell P. 2009. A network meta-analysis of randomized controlled trials of biologics for rheumatoid arthritis: a Cochrane overview. CMAJ. 181(11):787-96. PMID: 19884297

Singh JA, Murphy S, Bhandari M. 2009. Assessment of the methodologic quality of medical and surgical clinical trials in patients with arthroplasty. J Rheumatol. 36(12):2642-54. PMID: 19884268

Singh JA, Christensen R, Wells GA, Suarez-Almazor ME, Buchbinder R, Lopez-Olivo MA, Tanjong Ghogomu E, Tugwell P. 2009. Biologics for rheumatoid arthritis: an overview of Cochrane reviews. Cochrane Database Syst Rev. 7(4):CD007848. Review. PMID: 19821440

Maxwell L, Singh JA. 2009. Abatacept for rheumatoid arthritis. Cochrane Database Syst Rev. 7;(4):CD007277. Review. PMID: 19821401



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