Graciela S. Alarcón, MD, MPH

AlarconJane Knight Lowe
Emeritus Professor of Medicine

 

Address: 

Faculty Office Towers, room 830
510 20th Street South
Birmingham, Alabama 35294-3408



Telephone:(205) 422-0983
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Education


BS, Facultad de Ciencias, Universidad Nacional Mayor de San Marcos. Lima, Perú, 1961
MD, Facultad de Medicina, Universidad Peruana Cayetano Heredia. Lima, Perú, 1967
Fellowship (Clinical), Department of Medicine, Johns Hopkins University, School of Medicine. Baltimore City Hospitals, Baltimore, MD, 1969
Master in Public Health (M.P.H.), Johns Hopkins University, School of Hygiene and Public Health, Baltimore, MD, 1972
Doctor in Medicine, Universidad Peruana Cayetano Heredia. Lima, Perú, 1972
Fellowship (Research), Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, 1981

 

Selected Honors and Awards


1964 Diploma presented by the Peruvian Government recognizing voluntary work at the Sierra Indian Communities of Cuzco, Perú.
1971- 1972

Recipient of Merck, Sharp & Dohme Scholarship, Master of Public Health, Johns Hopkins University. Baltimore, MD

1980 American Rheumatism Association Senior Rheumatology Scholar Award
1988 Mexican Society of Rheumatology, Professor of the Year
1997 Virginia Engalichteff Award for Impact on Quality of Life, Arthritis Foundation. Denver, CO
2003 Outstanding Faculty-The University of Alabama at Birmingham Women's Center
2004 Pfizer Visiting Professor - Vanderbilt University- Nashville, TN
2006

Keynote Speaker,  Pan American League of Associations of Rheumatologists. Lima, Perú

2008 ACR Master, ACR Annual Scientifie Meeting, San Francisco, CA
2008 PANLAR Master, PANLAR Scientific Meeting, Guatemala City, Guatemala
2009 Dean's Award for Academic Execellence. The University of Alabama at Birmingham, Birmingham, Alabama
2000 & 2010 Visiting Professor, Argentinean Society of Rheumatology

 

Clinical, Research and Education Interests


I joined the Faculty at UAB in 1981 after being a Research Fellow for about 18 months. I am currently Emeritus Professor and although not in Birmingham, I am still involved in mentoring fellows and collaborating with the LFA, LCTC, GLADEL as the need arises. During my stay at UAB and prior to that at my alma mater (Universidad Peruana Cayetano Heredia in Lima, Perú), I have been involved in the training of clinical and research fellows. In fact, after my US training (1968-1972), I started the first training program in Rheumatology and the first Rheumatology Unit in Perú. Whether in Perú or in the US, I have attended their clinics, have rounded with them, and foremost I have been stimulating them to always keep an open and inquisitive mind in dealing with their day-to-day activities being those in the clinic or in the research setting. I can say that over 60% of the fellows graduating from UAB between 1981 and the early 2000's, when I became more involved in the training of clinical research fellows (vide infra), have had the opportunity to publish their clinical experience under my mentorship and with my unconditional support. Of course, not all of them have become academicians or researchers in their own right, but I have been quick to point out to all of them that the proper appreciation of what research entails or the amount of work that goes into a published paper, can only come from personally going through the same experience.

Although I have been involved in mentoring Junior Faculty and clinical research fellows in the past, it has been only since 2002 that I have had the opportunity to LUMINAcollaboratorshave the funding to support them for the conduct of research in lupus. These fellows have used the very rich database from LUMINA, a multi-ethnic cohort of lupus patients established in collaboration with Drs. John Reveille (UT-Houston, TX) and Luis Vilá (U- Puerto Rico, San Juan, PR) in the early 1990's. Participating in the training of these young physicians while continuing to mentor Junior Faculty and clinical fellows, as time permits, has been, and continues to be, one of the most rewording but also challenging experiences of my academic life as a rheumatologist. I have received funding for two additional years, so this experience will continue into 2008.  For the most part, these trainees have come with limited research experience; despite that, they have performed spectacularly well. In addition to participating in data collection on patients from the cohort, they have generated their own sub-projects and taken them to completion including the publication of their findings in prestigious rheumatology journals.  The fruits of LUMINA have been summarized in a special article published in the Journal Lupus in 2008. Moreover, the salient finding from the LUMINA study were highlighted in an article published in The Rheumatologist in the Spring of 2011. At the present time, I continue to be involved in the work of the fellows that trained with me over the last few years (Drs. Durán-Barragán, González, Pons-Estel and Burgos) who are conducting research in lupus in their country of origin. In parallel I am assisting the LCTC in the establishesment of a national registry of lupus patients (US and Canada).

 

Selected Publications


Fernandez M, Alarcón GS, Apte M, Andrade R, Vila LM, Reveille JD. 2007. Systemic Lupus erythematosus in a multiethnic U.S. cohort (LUMINA) XLIII: The significance of thrombocytopenia as a prognostic factor. Arthritis Rheum 56:614-21. PMID: 17921793


Andrade RM, Alarcón GS, Fernández M, Apte M, Vilá LM, Reveille JD. 2007. Accelerated damage accrual among men with systemic lupus erythematosus: XLIV. Results from a multiethnic US cohort. Arthritis Rheum 56:622-30. PMID: 17265497


Alarcón GS, McGwin G, Jr., Bertoli AM, Fessler BJ, Calvo-Alén J, Bastian HM, Vilá LM, Reveille JD, for the LUMINA Study Group:  Effect of hydroxychloroquine in the survival of patients with systemic lupus erythematosus.  Data from LUMINA, a multiethnic US cohort (LUMINA L). 2007. Ann Rheum Dis 66:1168-72. PMID: 17389655


González LA, McGwin G Jr, Durán S, Pons-Estel GJ, Apte M, Vilá LM, Reveille JD, Alarcón GS. 2008. Predictors of Premature Gonadal Failure in Patients with Systemic Lupus Erythematosus. Results from LUMINA, a Multiethnic US Cohort (LUMINA LVIII). Ann Rheum Dis 67:1170-3. PMID: 18299303


Durán-Barragan S, McGwin G, Jr. Vilá LM, ReveilleJD, Alarcón GS. 2008. Angiotensin-converting enzyme inhibitors delay the occurrence of renal involvement and are associated with a decreased risk of disease activity in patients with systemic lupus erythematosus.  Results from LUMINA (LIX): A multiethnic US cohort.  Rheumatology 47:1093-6. PMID: 18511474


Danila M, Pons-Estel GJ, Zhang J, Vilá LM, Reveille JD, Alarcón GS . 2008. Renal damage is the most important predictor of mortality within the damage index: data from LUMINA, a multiethnic US cohort. Rheumatology 48:542-5. PMID: 19233884


Burgos PI, Perkins EL, Pons-Estel GJ, Kendrick SA, Liu JM, Kendrick WT, Cook WJ, Julian BA, Alarcón GS, Kew II CE. 2009. Risk Factors and Impact of Recurrent Lupus Nephritis in Transplanted Patients with Systemic Lupus Erythematosus:  Data from a Single US Institution. Arthritis Rheum 60:2757-66. PMID: 19714623


Uribe AG, Romero Diaz J, Apte M, Fernandez M, Burgos PI, Reveille JD, Sanchez-   Guerrero J, Alarcón GS. 2009. Impact of immigration on the clinical espression of systemic lupus erythematosus: A comparative study of Hispanic patients residing in the US and Mexico. Rheumatology 48: 1392-7. PMID: 19717548


Pons-Estel GJ, Alarcón GS, McGwin G Jr, Danila MI, Zhang J, Bastian HM, Reveille JD, Vilá LM. 2009. Lumina Study Group. Protective effect of hydroxychloroquine on renal damage in patients with lupus nephritis: LXV, data from a multiethnic US cohort. Arthritis Rheum. 2009 61:830-9. PMID: 19479701


Craig SM, Yu F, Curtis JR, Alarcón GS,Conn DL, Jonas B, Callahan LF, Smith EA, Moreland LW, Bridges SL Jr, Mikuls TR. 2010. Vitamin D status and its associations with disease activity and severity in African Americans with recent-onset rheumatoid arthritis. J Rheumatol. 37(2):275-81 PMID: 20032100


Shinjo SK, Bonfá E, Wojdyla D, Borba EF, Ramirez LA, Scherbarth HR, Brenol JC, Chacón-Diaz R, Neira OJ, Berbotto GA, De La Torre IG, Acevedo-Vázquez EM, Massardo L, Barile-Fabris LA, Caeiro F, Silveira LH, Sato EI, Buliubasich S, Alarcón GS, Pons-Estel BA; Grupo Latino Americano de Estudio del Lupus Eritematoso (Gladel). 2010. Antimalarial treatment may have a time-dependent effect on lupus survival: data from a multinational Latin American inception cohort. Arthritis Rheum. 62(3):855-62. PMID: 20131238


Kelley JM, Hughes LB, Malik A, Danila MI, Edberg Y, Alarcón GS, Conn DL, Jonas BL, Callahan LF, Smith EA, Brasington RD, Edberg JC, Kimberly RP, Moreland LW, Bridges SL. 2010. Genetic variants of STAT4 associated with rheumatoid arthritis in persons of Asian and European ancestry do not replicate in African Americans.Ann Rheum Dis. 69(4):625-6. PMID: 20237121


Burgos PI, Causey ZL, Tamhane A, Kelley JM, Brown EE, Hughes LB, Danila MI, van Everdingen A, Conn DL, Jonas BL, Callahan LF, Smith EA, Brasington RD Jr, Moreland LW, van der Heijde DM, Alarcón GS, Bridges SL Jr. 2010. Association of IL4R single-nucleotide polymorphisms with rheumatoid nodules in African Americans with rheumatoid arthritis.Arthritis Res Ther. 12(3):R75. PMID: 20444266


Bridges SL Jr, Causey ZL, Burgos PI, Huynh BQ, Hughes LB, Danila MI, van Everdingen A, Ledbetter S, Conn DL, Tamhane A, Westfall AO, Jonas BL, Callahan LF, Smith EA, Brasington R, Moreland LW, Alarcón GS, van der Heijde DM. 2010. Radiographic severity of rheumatoid arthritis in African Americans: results from a multicenter observational study. Arthritis Care Res (Hoboken). 62(5):624-31. PMID: 20461784


Freedman BI, Edberg JC, Comeau ME, Murea M, Bowden DW, Divers J, Alarcón GS, Brown EE, McGwin G Jr, Kopp JB, Winkler CA, Nelson GW, Illei G, Petri M, Ramsey-Goldman R, Reveille JD, Vilá LM, Langefeld CD, Kimberly RP. 2010. The Non-Muscle Myosin Heavy Chain 9 Gene (MYH9) Is Not Associated with Lupus Nephritis in African Americans. Am J Nephrol. 2010;32(1):66-72 PMID: 20523037


Burgos PI, McGwin G Jr, Pons-Estel GJ, Reveille JD, Alarcón GS, Vilá LM.2010. US patients of Hispanic and African ancestry develop lupus nephritis early in the disease course: data from LUMINA, a multiethnic US cohort (LUMINA LXXIV). Ann Rheum Dis. 70(2):393-394 PMID: 20627945


Harley IT, Niewold TB, Stormont RM, Kaufman KM, Glenn SB, Franek BS, Kelly JA, Kilpatrick JR, Hutchings D, Divers J, Bruner GR, Edberg JC, McGwin G Jr, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá-Pérez LM, Merrill JT, Gilkeson GS, Vyse TJ, Alarcón-Riquelme ME, Cho SK, Jacob CO, Alarcón GS, Moser KL, Gaffney PM, Kimberly RP, Bae SC, Langefeld CD, Harley JB, Guthridge JM, James JA. 2010. The role of genetic variation near interferon-kappa in systemic lupus erythematosus. J Biomed Biotechnol. 2010;2010. pii: 706825. Epub 2010 Jul 15. PMID: 20706608


Isenberg DA, Allen E, Farewell V, D'Cruz D, Alarcón GS, Aranow C, Bruce IN, Dooley MA, Fortin PR, Ginzler EM, Gladman DD, Hanly JG, Inanc M, Kalunian K, Khamashta M, Merrill JT, Nived O, Petri M, Ramsey-Goldman R, Sturfelt G, Urowitz M, Wallace DJ, Gordon C, Rahman A. 2011. An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA. Ann Rheum Dis. 70(1):54-9.  PMID: 20833737


Ruperto N, Hanrahan L, Alarcón G, Belmont H, Brey R, Brunetta P, Buyon J, Costner M, Cronin M, Dooley M, Filocamo G, Fiorentino D, Fortin P, Franks A Jr, Gilkeson G, Ginzler E, Gordon C, Grossman J, Hahn B, Isenberg D, Kalunian K, Petri M, Sammaritano L, Sánchez-Guerrero J, Sontheimer R, Strand V, Urowitz M, von Feldt J, Werth V, Merrill J. 2011. International consensus for a definition of disease flare in lupus. Lupus. 20(5):453-462. PMID: 21148601


Hanly JG, Urowitz MB, Jackson D, Bae SC, Gordon C, Wallace DJ, Clarke A, Bernatsky S, Vasudevan A, Isenberg D, Rahman A, Sanchez-Guerrero J, Romero-Diaz J, Merrill JT, Fortin PR, Gladman DD, Bruce IN, Steinsson K, Khamashta M, Alarcón GS, Fessler B, Petri M, Manzi S, Nived O, Sturfelt G, Ramsey-Goldman R, Dooley MA, Aranow C, Van Vollenhoven R, Ramos-Casals M, Zoma A, Kalunian K, Farewell V; for the Systemic Lupus International Collaborating Clinics (SLICC). 2011. SF-36 summary and subscale scores are reliable outcomes of neuropsychiatric events in systemic lupus erythematosus. Ann Rheum Dis. 70(6):961-967. PMID: 21342917


Ippolito A, Wallace DJ, Gladman D, Fortin PR, Urowitz M, Werth V, Costner M, Gordon C, Alarcón GS, Ramsey-Goldman R, Maddison P, Clarke A, Bernatsky S, Manzi S, Bae SC, Merrill JT, Ginzler E, Hanly JG, Nived O, Sturfelt G, Sanchez-Guerrero J, Bruce I, Aranow C, Isenberg D, Zoma A, Magder LS, Buyon J, Kalunian K, Dooley MA, Steinsson K, van Vollenhoven RF, Stoll T, Weisman M, Petri M. 2011. Autoantibodies in systemic lupus erythematosus: comparison of historical and current assessment of seropositivity. Lupus. 20(3):250-5. PMID: 21362750


Hughes T, Kim-Howard X, Kelly JA, Kaufman KM, Langefeld CD, Ziegler J, Sanchez E, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Martin J, Brown EE, Vilá LM, Alarcón GS, James JA, Gilkeson GS, Moser KL, Gaffney PM, Merrill JT, Vyse TJ, Alarcón-Riquelme ME; on behalf of the BIOLUPUS network, Nath SK, Harley JB, Sawalha AH. 2011. Fine mapping and trans-ethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21. Arthritis Rheum. 2011 Mar 18. doi: 10.1002/art.30320. [Epub ahead of print] PMID: 21425124


Vinet E, Clarke AE, Gordon C, Urowitz MB, Hanly JG, Pineau CA, Isenberg D, Rahman A, Wallace D, Alarcón GS, Bruce I, Petri M, Dooley MA, Kalunian K, Maddison P, Aranow C, van Vollenhoven R, Bernatsky S. 2011. Decreased live births in women with systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2011 Mar 18. doi: 10.1002/acr.20466. [Epub ahead of print] PMID: 21425248


Ramos PS, Williams AH, Ziegler JT, Comeau ME, Guy RT, Lessard CJ, Edberg JC, Zidovetzki R, Criswell LA, Gaffney PM, Graham DC, Graham RR, Kelly JA, Kaufman KM, Brown EE, Alarcón GS, Petri MA, Reveille JD, McGwin G, Vilá LM, Ramsey-Goldman R, Jacob CO, Vyse TJ, Tsao BP, Harley JB, Kimberly RP, Alarcón-Riquelme ME, Langefeld CD, Moser KL. 2011. Genetic analyses of interferon pathway-related genes reveals multiple new loci associated with systemic lupus erythematosus (SLE). Arthritis Rheum. 2011 Mar 24. doi: 10.1002/art.30356. [Epub ahead of print] PMID: 21437871


Costenbader KH, Desai A, Alarcón GS, Hiraki L, Shaykevich T, Brookhart MA, Massarotti E, Lu B, Solomon DH, Winkelmayer WC. 2011. Trends in the incidence, demographics and outcomes of end-stage renal disease due to lupus nephritis in the U.S., 1995-2006. Arthritis Rheum. 2011 Mar 28. doi: 10.1002/art.30293. [Epub ahead of print] PMID: 21445962


Hiraki LT, Lu B, Alexander SR, Shaykevich T, Alarcón GS, Solomon DH, Winkelmayer W, Costenbader KH. 2011. End-stage renal disease due to lupus nephritis among children in the U.S., 1995-2006. Arthritis Rheum. 2011 Mar 28. doi: 10.1002/art.30350. [Epub ahead of print] PMID: 21445963

 

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