Alexander Szalai, PhDProfessor

Shelby Building, Room 214
1825 University Boulevard

Telephone:(205) 975-6241



BSc (Dean's Honor List), University of Manitoba, Winnipeg, MB, Canada, 1979
MSc, (Zoology), University of Manitoba, Winnipeg, MB, Canada, 1986
PhD, (Immunoparasitology) University of Manitoba, Winnipeg, MB, Canada, 1990,
Research Fellow, Department of Microbiology, The University of Mississippi Medical Center, 1990-1992


Research Description

The overarching goal of my research is to understand the biological role of C-reactive protein (CRP, an important component of innate immunity) in the maintenance of health and the propagation of disease. Conditions of past and present research interest include: systemic lupus erythematosus, multiple sclerosis, rheumatoid arthritis, septic arthritis, diabetes, Alzheimer's, cardiovascular disease, microbial infection, and acute kidney injury. My research laboratory uses a multi-faceted approach that entails studies of CRP biology in transgenic and knockout mice and translational in vitro studies of human cells and DNA together aimed at revealing CRP genetic and phenotypic associations with disease. Our most recent work has led to the development of CRP lowering drugs, a deeper understanding the role of CRP in cardiometabolic disease, and the discovery of a role for CRP in the regulation of myeloid derived suppressor cells/peripheral tolerance. Ligand-bound CRP activates the complement system and binds to Fc receptors; therefore we also routinely study these two effector pathways.


Potential projects for trainees

Investigating the role of C-reactive protein in translational studies of :

  • ischemia-reperfusion injury
  • diabetes
  • systemic lupus
  • multiple sclerosis
  • peripheral tolerance



Click here for a complete list of publications. Below are a few selected papers



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