Research

Publications

Publications Resulting from Studies Utilizing CLEAR Data and Samples

June, 2011

CLEAR Published manuscripts

1)  Hughes LB, Moreland LW, and Bridges SL Jr.  Genetic influences on rheumatoid arthritis in African-Americans.  Immunol Res 26/1-3;15-26, 2002. 

2)  Bridges SL, Jr., Hughes LB, Mikuls TF, Howard G, Tiwari HK, Alarcón GS, Moreland LW, for CLEAR Investigators.  Early rheumatoid arthritis in African-Americans:  The CLEAR registry.  Clin Exp Rheum, 21 (Suppl 31):S138-S145, 2003. 

3)  Mikuls TR, Saag KG, Curtis J, Bridges SL Jr., Alarcón GS, Westfall AO, Lim SS, Smith EA, Jonas BL, Moreland LW, and the CLEAR Investigators.  The prevalence of osteoporosis and osteopenia among African Americans with early rheumatoid arthritis: the impact of ethnic-specific normative data.  J Natl Med Assoc 97(8):1155-60, 2005.  

4)  Mikuls TR, Holers VM, Parrish L, Kuhn KA, Conn DL, Gilkeson G, Smith EA, Kamen DL, Jonas BL, Callahan LF, Alarcon GS, Howard G, Moreland LW, Bridges SL Jr.  Anti-cyclic citrullinated peptide antibody and rheumatoid factor isotypes in African Americans with early rheumatoid arthritis. Arthritis Rheum 54:3057-9, 2006. 

5)  Hughes LB, Morrison D, Kelley JM, Padilla MA, Vaughan LK, Westfall AO, Mikuls TR, Holers VM, Parrish L, Alarcón GS, Conn DL, Jonas BL, Callahan LF, Smith EA, Gilkeson GS, Howard G, Moreland LW, Patterson N, Reich D, Bridges SL Jr.  The HLA-DRB1 shared epitope is associated with susceptibility to rheumatoid arthritis in African-Americans through European genetic admixture.  Arthritis & Rheumatism 58:349-58, 2008.

6)  Kelley JM, Hughes LB, Bridges SL Jr.  Does gamma-aminobutyric acid (GABA) influence the development of chronic inflammation in rheumatoid arthritis?  Journal of Neuroinflammation 5:1, Jan 3, 2008; [Epub ahead of print]. 

7)  Mikuls TR, Hughes LB, Westfall AO, Holers VM, Parrish L, van der Heijde D, van Everdingen M, Alarcón GS, Conn DL, Jonas B, Callahan LF, Smith EA, Gilkeson G, Howard G, Moreland LW, Bridges SL Jr.  Cigarette smoking, disease severity, and autoantibody expression in African Americans with recent-onset rheumatoid arthritis.  Annals of the Rheumatic Diseases, Jan 15, 2008; [Epub ahead of print]. 

8)  Lin H-Y, Desmond R, Bridges SL Jr., Soong S-J.  Variable selection in logistic regression for detecting SNP-SNP interactions:  The rheumatoid arthritis example.  European Journal of Human Genetics Jan 30, 2008; [Epub ahead of print]. 

9)  Kelley JM, Hughes LB, Feng R, Liu N, Padilla MA, Vaughan LK, Bridges SL Jr.  Evaluating linkage disequilibrium and recombination provides a haplotype-tagging SNP panel of the MHC in African-Americans.  Genes and Immunity, Feb 28, 2008; [Epub ahead of print]. 

10)  Curtis JR, Arora T, Donaldson M, Alarcón GS, Callahan LF, Moreland LW, Bridges SL Jr, Mikuls TR.  Skeletal health among African Americans with recent-onset rheumatoid arthritis.  Arthritis Rheum  61(10):1379-86, 2009. 

11) Craig SM, Yu F, Curtis JR, Alarcón GS, Conn DL, Jonas BL, Callahan LF, Smith EA, Moreland LW, Bridges SL Jr., Mikuls TR, and the CLEAR Investigators.  Vitamin D status and its associations with disease activity and severity in African Americans with recent onset rheumatoid arthritis.  Journal of Rheumatology 37:275-81, 2010.  Epub 2009 Dec 23.

12) Reynolds RJ, Kelley JM, Hughes LB, Yi N, Bridges SL Jr., for the CLEAR Investigators.  Genetic association of htSNPs across the major histocompatibility complex with rheumatoid arthritis in an African American population.  Genes and Immunity 11:94-7, 2010.  Epub 2009 Sep 10.

13) Kelley JM, Hughes LB, Malik A, Danila MI, Edberg Y, Alarcón GS; Conn DL; Jonas BL, Callahan LF, Smith EA, Brasington RD, Jr., Edberg JC; Kimberly RP, Moreland LW, Bridges SL Jr.  Genetic variants of STAT4 associated with rheumatoid arthritis in persons of European and Asian ancestry do not replicate in African-Americans.  Annals of the Rheumatic Diseases, 69:625-6, 2010. 

14)  Bridges SL Jr., Causey ZL, Burgos PI, Huynh QN, Hughes LB, Danila MI, van Everdingen A, Ledbetter S, Conn DL, Tamhane A, Westfall AO, Jonas BL, Callahan LF, Smith EA, Brasington R, Moreland LW, Alarcón GS, van der Heijde DM.  Radiographic severity of rheumatoid arthritis in African-Americans:  Results from the CLEAR Registry.  Arthritis Care & Research, 62(5):624-31, 2010. 

15)  Zhang J, Redden DT, McGwin G Jr., Callahan LF, Smith EA, Alarcón GS, Moreland LW, van der Heijde DM, Brown EE, Arnett DK, Mikuls TR, Bridges SL Jr., for the CLEAR Investigators.  Generalized bone loss as a predictor of 3-year radiographic damage in African American patients with recent-onset rheumatoid arthritis.  Arthritis & Rheumatism, 62:2219-26, 2010. 

16)  Burgos PI, Causey ZL, Tamhane A, Kelley JM, Brown EE, Hughes LB, Danila MI, van Everdingen A, Conn DL, Jonas BL, Callahan LF, Smith EA, Brasington RD, Jr., Moreland LW, van der Heijde DM, Alarcón GS, Bridges SL Jr.  Association of IL4R single nucleotide polymorphisms with rheumatoid nodules in African Americans with rheumatoid arthritis.  Arthritis Reseach & Therapy, 2010 May 5;12(3):R75. [Epub ahead of print].

17)  Tan W, Wu H, Zhao J, Derber LA, Lee DM, Shadick NA, Conn DL, Smith EA, Gersuk VH, Nepom GT, Moreland LW, Furst DE, Thompson SD, Jonas BL, Holers VM, Glass DN, Chen PP, Bridges SL Jr., Weinblatt ME, Paulus HE, Tsao BP.  A functional RANKL polymorphism associated with younger age at onset of rheumatoid arthritis.  Arthritis & Rheumatism.  62, 2864-75, 2010.  2010 Jun 7. [Epub ahead of print]

18)  McElroy JP, Cree BAC, Caillier SJ, Gregersen PK, Herbert J, Khan OA, Freudenberg J, Lee A, Bridges SL Jr., Hauser SL, Oksenberg JR, Gourraud P-A.  Refining the association of MHC with multiple sclerosis in African Americans.  Human Molecular Genetics.  19:3080-8, 2010.  Epub 2010 May 12.  PMCID:  PMC2901136. 

19)  Mikuls TR, Sayles H, Yu F, LeVan T, Gould KA, Thiele GM, Conn DL, Jonas BL, Callahan LF, Smith EA, Brasington RD Jr. Moreland LW, Reynolds RJ, Bridges SL Jr.  Associations of cigarette smoking with rheumatoid arthritis in African Americans.  Arthritis & Rheumatism, 2010 Aug 18. [Epub ahead of print]

20)  Curtis JR, Jain A, Askling J, Bridges SL Jr., Carmona L, Dixon W, Finckh A, Hyrich K, Greenberg J, Kremer J, Listing J, Michaud K, Mikuls TR, Shadick N, Solomon DH, Wolfe F, Zink A.  A comparison of patient characteristics and outcomes in selected European and US rheumatoid arthritis registries.  Seminars in Arthritis and Rheumatism 40(1):2-14.e1, 2010.  

21)  Hughes LB, Reynolds RJ, Brown EE, Kelley JM, Thomson B, Conn DL, Jonas BL, Westfall AO, Padilla MA, Callahan LF, Smith EA, Brasington RD Jr., Edberg JC, Kimberly RP, Moreland LW, Plenge RM, Bridges SL Jr.  Most common SNPs associated with rheumatoid arthritis in subjects of European ancestry confer risk of rheumatoid arthritis in African-Americans.  Arthritis & Rheumatism 2010 Dec;62(12):3547-53.  2010 Oct 22. [Epub ahead of print].  PMCID: PMC3030622.

22)  Mikuls TR, Gould KA, Bynoté KK, Yu F, LeVan TD, Thiele GM, Michaud KD, O'Dell JR, Reimold AM, Hooker R, Caplan L, Johnson DS, Kerr G, Richards JS, Cannon GW, Criswell LA, Noble JA, Bridges SL Jr., Hughes LB, Gregersen PK.  Anti-citrullinated protein antibody (ACPA) in rheumatoid arthritis: Influence of an interaction between HLA-DRB1 shared epitope and a deletion polymorphism in glutathione S-transferase in a cross-sectional study.  Arthritis Research & Therapy 2010;12(6):R213. Epub 2010 Nov 18. PMCID: PMC3046521.

23)  Song JJ, Hwang I, Cho KH, Garcia MA, Kim AJ, Wang TH, Lindstrom TM, Lee AT, Nishimura T, Zhao L, Morser J, Nesheim M, Goodman SB, Lee DM, Bridges, SL Jr. for the CLEAR Registry, Gregersen PK, Leung LL, Robinson WH.  Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis.  Journal of Clinical Investigation, in press. 

 

CLEAR Published abstracts (as of June 22, 2011)

1)  Callahan LF, Jonas B, Westfall AO, Smith EA, Conn D, Oliver E, Howard G, Bridges, Jr. SL, Moreland, LW.  Health-related quality of life in African Americans with early rheumatoid arthritis.  Arthritis Rheumƒnƒn 48:9 (Suppl), S249, 2003. 

2)  Callahan LF, Jonas B, Westfall AO, Gilkeson G, Conn D, Gala P, Howard G, Bridges, Jr. SL, Moreland, LW.  Complementary and alternative medicine use in African Americans with early rheumatoid arthritis.  Arthritis Rheumƒnƒn 48:9 (Suppl), S250, 2003. 

3)  Mikuls TR, Saag KG, Westfall AO, Howard G, Lim SS, Smith EA, Jonas BL, Bridges, Jr. SL, Moreland LW.  High prevalence of osteopenia/osteoporosis among African Americans with early rheumatoid arthritis.  Arthritis Rheum 48; 9(Suppl), S299, 2003. 

4) Alarcón GS, Westfall AO, Gilkeson G, Callahan L, Conn D, Bridges Jr., SL, Howard G, Moreland LW.  Joint damage occurs early in African Americans with rheumatoid arthritis.  Arthritis Rheum  48; 9(Suppl), S109, 2003. 

5)  Mikuls TR, Hughes LB, Alarcón GS, Conn DL, Jonas BL, Callahan L, Smith E, Gilkeson G, Howard G, Moreland LW, Bridges, Jr., SL.  Association of single nucleotide polymorphisms (SNPs) in the vitamin D receptor gene (VDR) with bone mineral density (BMD) in African Americans with early rheumatoid arthritis (RA).  Arthritis Rheum  9(Suppl), S118, 2005.

6)  Hughes LB, Alarcón GS, Conn DL, Jonas B, Callahan L, Smith E, Gilkeson G, Howard G, Moreland LW, Bridges, Jr., SL.  HLA DRB1 alleles containing the shared epitope are associated with rheumatoid arthritis in African Americans.  Arthritis Rheum  9(Suppl), S149, 2005. 

7) Mikuls TR, Holers VM, Parrish L, Kuhn KA, Alarcón GS, Conn DL, Gilkeson G, Smith EA, Kamen DL, Jonas BL, Callahan LF, Howard G, Moreland LW, Bridges, Jr., SL.  Anti-cyclic citrullinated peptide (CCP) antibody and rheumatoid factor (RF) isotypes in African Americans with early rheumatoid arthritis: Results from the CLEAR Registry.  Arthritis Rheum  9(Suppl), S189, 2006. 

8)  Morrison D, Bridges, Jr.,  SL, Westfall AO, Tiwari HK, Alarcón GS, Conn DL, Jonas BL, Callahan LF, Smith EA, Gilkeson GS, Howard G, van der Heijde D, Moreland LW, Hughes LB.  Novel association of a functional single nucleotide polymorphism in the BTNL2 gene with susceptibility to rheumatoid arthritis and baseline radiographic severity in African-Americans independent of HLA DRB1: Results from the CLEAR Registry.  Arthritis Rheum  9(Suppl), S391, 2006. 

9)  Hughes LB, Moreland LW, Howard G, Alarcón GS, Allison DB, Westfall AO, Conn DL, Jonas BL, Callahan LF, Smith EA, Gilkeson GS, Fraser P, Reich D, Bridges, Jr., SL.  The HLA DRB1 shared epitope is associated with rheumatoid arthritis in African-Americans and correlates with higher estimated admixture of European ancestry: Results from the CLEAR Registry.  Arthritis Rheum  9(Suppl), S894, 2006. 

10)  Wu H, Bridges Jr., SL, Park GS, Holers VM, Parrish LA, Conn DL, Jonas BL, Smith EA, Moreland L, Paulus HE, Tsao BP.  Co-occurrence of RANKL and HLA-DRB1 genotypes may contribute to younger age at onset of seropositive rheumatoid arthritis in African Americans: Analysis of The CLEAR Registry.  Arthritis Rheum  9(Suppl), S394, 2006. 

11)  Hughes LB, Morrison D, Dechanuwong P, Westfall AO, Tiwari HK, Alarcón GS, Conn DL, Jonas BL, Callahan LF, Smith EA, Gilkeson GS, Howard G, Moreland LW, Bridges, Jr., SL.  Genetic and non-genetic risk factors associated with rheumatoid arthritis susceptibility in African-Americans: Results from the CLEAR Registry.  Arthritis Rheum  9(Suppl), S400, 2006. 

12)  Hughes LB, Morrison D, Westfall AO, Tiwari HK, Alarcón GS, Conn DL, Jonas BL, Callahan LF, Smith EA, Gilkeson GS, Howard G, van der Heijde D, Parrish LA, Holers VM, Moreland LW, Bridges, Jr., SL.  Genetic and non-genetic factors associated with baseline radiographic erosions in African-Americans with early rheumatoid arthritis: Results from the CLEAR Registry.  Arthritis Rheum  9 (Suppl), S401, 2006. 

 13)  Mikuls TR, Hughes LB, Westfall AO, Howard G, Alarcon GS, Holers VM, Conn DL, Smith EA, Gilkeson GS, van der Heidje D, Jonas BL, Callahan LF, Bridges Jr. SL.  The association of cigarette smoking with disease characteristics in African-Americans with early rheumatoid arthritis.  Arthritis Rheum  56; 9 (Suppl), S832, 2007. 

14)  Wu H, Bridges Jr., SL, Park G, Maranian P, Holers VM, Parrish L, Conn D, Jonas B, Smith E, Moreland L, Furst D, Thompson H, Glass D, Paulus H, Tsao B.  RANKL promoter SNPs associated with early onset RA.  Arthritis Rheum  58; 9 (Suppl), S517, 2008. 

15)  Callahan LF, Shreffler J, Jonas BL, Alarcon GS, Conn DL, Smith EA, Howard G, Moreland LW, Bridges Jr. SL.  The associations of education and income with health status outcomes in African-Americans with early rheumatoid arthritis.  Arthritis Rheum  58; 9 (Suppl), S860, 2008. 

16)  Mikuls TR, Yu F, Craig SM, Moreland LW, Bridges Jr., SL, CLEAR Investigators.  The circulating 25-OH vitamin D concentrations in African-Americans with recent onset rheumatoid arthritis.  Arthritis Rheum  58; 9 (Suppl), S876, 2008. 

17)  Tan W, Wu H, Derber LA, Lee DM, Shadick NA, Smith EA, Gersuk VH, Nepom GT, Moreland LW, Furst DE, Thompson SD, Jonas BL, Holers VM, Chen PP, Glass DN, Bridges Jr. SL, Weinblatt ME, Paulus HE and Tsao BP.  A Functional RANKL Promoter SNP Associated with Younger Age at Onset of Rheumatoid Arthritis.  Arthritis Rheum  60; 9 (Suppl), S140, 2009. 

18)  Bridges SL Jr., Causey ZL, Burgos PI, Hughes LB, Danila MI, van Everdingen A, Ledbetter S, Conn DL, Tamhane A, Westfall AO, Jonas BL, Callahan L, Smith E, Brasington R, Moreland LW, Alarcón GS, van der Heijde DM.  Radiographic Severity of Rheumatoid Arthritis in African-Americans: Results From the CLEAR Registry.  Arthritis Rheum  60; 9 (Suppl), S128, 2009. 

19)  Danila MI, Chen L, van der Heijde DM, Conn DL, Jonas BL, Callahan LF, Smith EA, Brasington, Jr. RD, Moreland LW, Bridges SL, Jr. and Hughes LB.  C-reactive Protein (CRP) Single Nucleotide Polymorphisms (SNPs) are Associated with Radiographic Damage and Plasma CRP Levels in African Americans (AAs) with Early Rheumatoid Arthritis (RA).  Arthritis Rheum  62; 10 (Suppl), S450, 2010. 

20)  Song J, Hwang I, Wang T, Lee A, Bridges SL, Jr., Gregersen PK, Leung L, Robinson WH.  Thrombin-activatable carboxypeptidase B (CPB) plays a central role in downregulating inflammatory responses in rheumatoid arthritis by cleaving C5a.  Arthritis Rheum  62; 10 (Suppl), S576, 2010. 

 

 

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