Clinical Trials

researchBelow is a listing of our currently active clinical trials:

Efficacy & Safety of AM-101 in the Treatment of Acute Peripheral Tinnitus 2 (TACTT2) - The purpose of this research study is to test the safety and effectiveness of an investigational study drug, AM-101, when injected into the middle ear for treatment of acute tinnitus.

Principal Investigators: Garima Agarwal, MD and Richard Waguespack, MD

AM-101 in the Post-Acute Treatment of Peripheral Tinnitus 1 (AMPACT1) - An Open-Label Extension to the TACTT2 Study - The purpose of this research study is to test the safety and effectiveness of AM-101 over a longer treatment period with repeated treatment cycles when administered into the middle ear following previous treatment of tinnitus with either AM-101 or placebo in the TACTT2 study.

Principal Investigator: Garima Agarwal, MD

Voice and Swallowing Outcomes Following Revision Anterior Cervical Spine Surgery - The purpose of this research study is to document the voice and swallowing functions of patients undergoing revision anterior cervical spine surgery in an effort to find better ways to identify and treat complications that arise from this commonly performed procedure.

Principal Investigator: William Carroll, MD

Phase I, Open-Label Study Evaluating the Safety and Pharmacokinetics of Escalating Doses of Cetuximab-IRDye800 as an Optical Imaging Agent to Detect Cancer During Surgical Procedures - This is a Phase I trial designed to evaluate the safety of escalating dose levels of an investigational study drug, conjugated cetuximab-IRDye800, used in subjects with head and neck squamous cell carcinoma who undergo surgery with curative intent. It is hoped that this study will assist with finding better methods for identifying cancer intraoperatively for a more complete surgical resection.

Principal Investigator: William Carroll, MD

Comparison of Methods for Performing Glottic Biopsies of Potentially Nonbenign Lesions - There are multiple methods of performing a biopsy of a vocal fold lesion that are considered standard of care. The most common form of biopsy uses cup forceps; however, a micro-elevated biopsy may yield improved pathologic diagnosis. This study will compare results from these two types of biopsies as well as assessing post-procedure changes in voice, need for further treatment, and/or recurrence following treatment.

Principal Investigator: Richard McHugh, MD

Prospective Observational Study to Evaluate Outcomes from Trans-oral Base of Tongue Resection for Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) - The purpose of this study is to evaluate the use of robotic-assisted surgery for better visibility and access for trans-oral base of tongue resection, a common treatment for obstructive sleep apnea.

Principal Investigator: Kirk Withrow, MD

Use of Porcine Small Intestinal Submucosa (SIS) Graft to Aid in Nasal Septal Remucosalization and Tissue Healing in Patients Following Use of Nasoseptal Flap Elevation for Skull Base Surgery - The purpose of this study is to demonstrate the utility of porcine small intestinal submucosa (SIS) as a graft material that may aid in the natural healing process of freshly exposed bone and cartilage in the nasal cavity.

Principal Investigator: Bradford Woodworth, MD

Chloride Secretagogues for Acquired CFTR Dysfunction in Chronic Rhinosinusitis - The purpose of this study is to determine if acquired (partial) Cystic Fibrosis Transmembrane conductance Regulator (CFTR) deficiency contributes substantially to the pathogenic mechanisms underlying Chronic Rhinosinusitis (CRS), creating a localized environment that impairs mucociliary clearance (MCC).

Principal Investigator: Bradford Woodworth, MD