Pulmonary Arterial Hypertension (PAH) is a heterogeneous group of diseases with high mortality, difficult diagnosis, limited available treatment, and no cure. The Pulmonary Hypertension Breakthrough Initiative (PHBI) is dedicated to comprehensive biobanking of human lungs with PAH and controls, supported by a detailed clinical annotation of the accrued specimens. UAB serves as the Tissue Handling and Pathology Core for the PHBI, which includes six transplant centers that collect explanted lung tissue from patients with interstitial pulmonary arterial hyperplasia and from control patients. In addition to working with Dr. Keith Wille (PI of UAB Transplant Site) to collect, process, and store tissue from eligible transplants that occur at UAB, our Tissue Handling and Pathology Core (Dr. Grizzle, PI) receives tissue samples from the other five transplant centers, stores it, then distributes it to approved researchers.
Started in 2006 with funding from the Cardiovascular Medical Research and Education Fund (CMRED), a non-profit fund operated solely for charitable, scientific and educational purposes, the PHBI now operates with additional support from the National Heart, Lung, and Blood Institute (NHLBI).
The objectives of the PHBI are to (1) establish a comprehensive biorepository of specimens from subjects with pulmonary arterial hypertension and failed donor controls, (2) provide the infrastructure to support human tissue based research in PAH via integrated cores devoted to Administration, Tissue Handling and Pathology, Cell Line Development, and Genomic Characterization and Cataloging, and (3) develop and implement an interface for consultation of research design and analysis to enhance broader scientific investigation.
Frozen samples of tissue and/or blood products, frozen sections, paraffin blocks, samples from paraffin-embedded blocks, cells, cDNA, RNA, and DNA banked for the PHBI are made available to investigators within the United States.
Investigators interested in applying for specimens from the PHBI should contact the PHBI Data Coordinating Center at PHBI-DCC@umich.edu to obtain the applicant user guide and other applicant information.