Sunil Sudarshan, M.D.

Sudarshan_06Associate Professor
(205) 934-9175

Clinical Subspecialty and Areas of Interest

Urologic Oncology
Scientific research understanding the molecular basis of renal cancer

Education and Degrees

Duke University, Medical Doctor 1999
Medical Univ. of South Carolina, Resident Urology 2005
National Cancer Institute, Fellowship Urologic Oncology 2007

Awards and Honors      

American Urological Association Foundation/Astellas Rising Star in Urology Award, 2009
Gerald Murphy AUA Scholar, 2003
Montague Boyd Essay Contest, Southeastern Section AUA, Second Place, 2003
Abney Foundation Research Scholarship, 2000 
Eugene A. Stead Research Scholarship, Duke University School of Medicine, 1997
Dean’s Recognition Award, Duke University School of Medicine, 1999
Undergraduate Research Scholarship, American Chemical Society, 1994
Hartford Research Scholar in Geriatric Medicine, Duke University, 1993

Recent Publications

Shanmugasundaram K, Block K, Nayak BK, Livi CB, Venkatachalam MA, Sudarshan S.PI3K regulation of the SKP-2/p27 axis through mTORC2.  Oncogene. 2012 Jun 25. doi: 10.1038/onc.2012.226. [Epub ahead of print].

Nayak BK, Feliers D, Sudarshan S, Friedrichs WE, Day RT, New DD, Fitzgerald JP, Eid A, Denapoli T, Parekh DJ, Gorin Y, Block K. Stabilization of HIF-2α through redox regulation of mTORC2 activation and initiation of mRNA translation. Oncogene. 2012 Aug 6. doi: 10.1038/onc.2012.333.

Fitzgerald JP, Nayak B, Shanmugasundaram K, Friedrichs W, Sudarshan S, Eid AA, Denapoli T, Parekh DJ, Gorin Y, Block K.  Nox4 Mediates Renal Cell Carcinoma Cell Invasion through Hypoxia-Induced Interleukin 6- and 8- Production. PLoS One. 2012;7(1):e30712. Epub 2012 Jan 27.                                                                                            

Sudarshan, S, Shanmugasundaram K, Naylor SL, Lin S, Livi C, Galindo CA, Parekh DJ, Yeh I-T, Sun L, and Block K.  Reduced Expression of Fumarate Hydratase in Clear Cell Renal Cancer Promotes HIF-2α Accumulation, Migration, and Invasion.  PLoS One. 2011;6(6):e21037. Epub 2011 Jun 14.

Sourbier C, Valera-Romero V, Giubellino A, Yang Y, Sudarshan S, Neckers L, Linehan WM. Increasing reactive oxygen species as a therapeutic approach to treat hereditary leiomyomatosis and renal cell carcinoma.  Cell Cycle.  2010 Oct: 20(9): 4183-9.

Liu NW, Khurana K, Sudarshan S, Pinto PA, Linehan WM, Bratslavsky G. Repeat partial nephrectomy on the solitary kidney: surgical, functional and oncological outcomes. J Urol. 2010 May; 183(5):1719-24