UAB researcher Andra Frost, M.D., associate professor in the Department of Pathology and scientist in the Experimental Therapeutics Program of the UAB Comprehensive Cancer Center, has been awarded a Susan G. Komen for the Cure research grant for $600,000 to study the role of the oncogene Gli1 in the metastasis of triple negative breast cancer, an especially aggressive subtype of the disease. An oncogene is a gene that has the potential to cause cancer. In tumor cells, they are often mutated or expressed at high levels. Gli1 is known to regulate the presence of a variety of molecules that are important for cancer development, growth and metastasis. It mostly has been studied in skin and brain cancers, but its role in other cancers, such as breast cancer, is less established. Frost is hoping to understand how Gli1 is promoting the metastasis of triple negative breast cancer. Currently there are no widely used targeted therapies for the treatment of triple negative breast cancer. Ultimately, Frost says, “We want to show that inhibiting the function of the Gli1 will slow or stop the growth and metastasis of triple negative breast cancer.”
UAB Concert Choir to perform at festivals in England, the Netherlands
Tours like this are transformative experiences, says Director Brian Kittredge. The choir is requesting donations to help make the trip a reality for as many students as possible.UAB creates triple-threat cancer-fighting polymer capsules for guided drug deliveryThese microcarriers may offer an entirely different approach to treating solid human tumors of numerous pathologic subtypes by delivering their encapsulated drug cargo to a tumor and protecting against collateral tissue damage.posted today 351 viewsJournal: Researchers can track hazardous chemicals from fast-food wrappers in the bodyJust one month after major research findings showed dangerous PFAS present in more than one-third of fast food packaging tested, UAB and Notre Dame created a new technique to track PFASs in the body.posted yesterday 462 viewsMississippi teen battles colon cancer through phase I clinical trial at UAB
Unusual case of teen patient diagnosed with colorectal cancer receives innovative first-in-human clinical trial at UAB, reflecting a unique story of cancer and hope.Alabama Vaccine Research Clinic at UAB recruiting for groundbreaking HIV prevention research trial
A groundbreaking clinical research trial at UAB’s Alabama Vaccine Research Clinic to compare injectable PrEP versus a daily oral regimen for HIV prevention is now recruiting participants.Preterm babies born at 23 weeks’ or longer gestation benefit from mom’s receiving steroids prior to delivery
Antenatal corticosteroids given to high-risk moms are associated with better outcomes for babies born prematurely.Study finds parents’ perceptions play key role in teens’ driving preparednessOverall, parents believe their teens are safer than other drivers.posted 6 days ago 920 viewsThis weekend’s TEDxBirmingham will have UAB flavorBevan, Locke, Saag are among 12 speakers who will speak at the annual, independently organized event which will challenge attendees to embrace the event’s theme of possibility.
Genetic clues to kidney disease uncoveredUAB assays enabled the first genomewide association study of IgA1 O-glycosylation aberrancy in IgA nephropathy, a disease that frequently causes kidney failure.posted 14 days ago 2080 viewsUAB professor uses latest virtual reality technology to improve access to pedestrian safety educationA new mobile virtual reality system helps children learn to cross streets safely.posted 14 days ago 1386 viewsNew braces clinical trial sheds metal bracketsInflatable braces? A new clinical trial at the UAB School of Dentistry is hoping to make metal braces a thing of the past.posted 15 days ago 4445 viewsNew UAB undergraduate degree programs in genetics, genomic sciences and immunology now enrollingTwo new undergraduate programs — genetics and genomic sciences and immunology — are interdepartmental majors in the College of Arts and Sciences and School of Medicine.posted 16 days ago 3846 viewsStopping Alzheimer’s disease: Local research study featured in NewsweekUAB is a clinical site for the A4 Study of Alzheimer’s disease, recently featured in Newsweek magazine.posted 16 days ago 3095 viewsWallace, named first medical director of Telehealth, eyes statewide networkThe new UAB Medicine Telehealth team of Bart Kelly and Eric Wallace aim to steadily grow telehealth providers across the UAB health care spectrum “one program at a time.”posted 16 days ago 2066 viewsSchool of Dentistry ranks first in NIDCR funding for fifth straight yearUAB’s School of Dentistry has ranked first in NIDCR funding since 2012.posted 17 days ago 2624 viewsCastration-resistant prostate cancer cell growth impeded by EndostatinFailure of hormone deprivation therapy used to slow prostate cancer in patients leads to castration-resistant prostate cancer, a lethal form of advanced disease with limited treatment options. Endostatin, used in combination therapy, may help delay onset of castration-resistant disease.posted 20 days ago 1909 viewsSickle cell gene linked to elevated risk of kidney failure in UAB studyNew data from the REGARDS study show that blacks with the sickle cell trait are more likely to develop kidney failure requiring dialysis.posted 21 days ago 1458 viewsNominate UAB alumni for Excellence in BusinessThe National Alumni Society’s Top 25 program celebrates the success of Blazer-led companies.posted 22 days ago 774 viewsUAB to launch statewide genetics initiative for better health for all Alabama residentsUAB launches the Alabama Genomic Health Initiative, a statewide effort to use the power of genomics to improve health in Alabama.posted 21 days ago 3964 viewsUAB to provide paid leave benefits for organ donorsUAB employees who are living donors for solid organ or bone-marrow transplants may qualify for as many as four weeks paid leave, effective March 1.posted 29 days ago 1439 views
- Event Date March 25