Researchers have found that an interaction between a mutant gene and alpha synuclein in neurons leads to hallmark pathologies seen in Parkinson’s disease, findings that may lead to new mechanisms and targets for neuroprotection.
The biomarker, the protein kinase LRRK2, is a promising candidate for future exploration.
Results show that JAK/STAT pathway inhibitors may be a new class of therapeutic treatments for patients with Parkinson’s disease. Acting by reducing inflammation, they prevent neurodegeneration in animal models and may be an important new approach to slow progression of the disease.
UAB joins with leading Parkinson’s disease organizations for a Birmingham conference.
Published in Service to Community
A key role for microRNA-155 in brain inflammation and neurodegeneration makes it both a potential therapeutic target and a biomarker for this progressive disorder.
Parkinson Association of Alabama will hold walk to raise research funding for Parkinson’s disease.
Published in Service to Community
A new pilot study led by Shannon Morrison, Ph.D., is exploring the effects of a high-fat, low-carbohydrate diet with adequate protein in older persons living with HIV.
Published in Focus on Patient Care
UAB's strengths in clinical care and research are powering an interdisciplinary expedition into largely uncharted territory: neuroinflammatory mechanisms in Parkinson's disease.
Gene mastermind Shawn Levy, Ph.D., and his team at the HudsonAlpha Genomic Services Laboratory are helping UAB investigators — and researchers from around the world — crack the mysteries of life.
The drug inhibits the activity of a kinase enzyme called LRRK2, and it showed no pathology in rat lungs, kidneys or livers.

UAB is one of five centers named to host the first class of fellows in the Edmond J. Safra Fellowship in Movement Disorders.

Published in Faculty Excellence
A new study says that the cost of a medication may play a very important role in a patient’s perception of whether it works.
Philanthropic support has enabled the UAB Department of Neurology to make huge strides in knowledge of diseases such as Parkinson’s.

A UAB neuroscience student has received a summer fellowship from the Parkinson’s Disease Foundation.

Published in Student Experience
New drugs to slow or even prevent Parkinson’s could be in human studies as early as 2015.
Parkinson’s disease awareness is highlighted with official recognition from Alabama and the city of Birmingham in April.
Published in Service to Community
UAB has teamed with the Michael J. Fox Foundation to look for genetic biomarkers for Parkinson’s disease.
Published in Focus on Patient Care
Researchers at UAB show that high-intensity strength training improves mobility, mood and overall quality of life for Parkinson’s patients.
Published in Focus on Patient Care

The program supports and cultivates students interested in Parkinson’s related research projects.

Published in Student Experience

UAB Neurology adds to evidence that massive, second-wave reaction kills nerve cells.

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