Simulation-based education is increasingly viewed as a crucial part of healthcare training programs. The benefits of simulation training include practicing and making mistakes in a risk-free environment, identifying sources of error in care processes prior to their implementation in practice and adapting scenarios for learners at multiple levels. In our clinical simulation laboratories, students practice real skills in a simulated environment. Our most realistic use of simulation for learning are our high-fidelity mannequins for adult, obstetrics, pediatric, and neonatal care. These mannequins can breathe, cry, and be programmed to respond physiologically to students’ interventions during scenarios designed to mimic actual patient situations.