Michael R. Frost, Ph.D.
Research Instructor, Vision Sciences

Contact Information
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Office – 205.934.6733

Physical Address
306 Worrell Building
924 18^th Street South

Mailing Address
1530 Third Avenue South
WORB 306
Birmingham, AL 35294-4390

Education: 

B.Sc. (Hons) – The University of Dundee; Dundee, Scotland, UK.

Ph.D. – The University of Wales; Cardiff, Wales, UK.

Postdoctoral – The Hong Kong Polytechnic University; Hong Kong SAR, China.

Administrative Responsibilities:

Secondary Appointments:

Personal:

Scholarly Activity:

Teaching -

N/A

Research -

During postnatal development of the eye there appears to be a vision-dependent mechanism that controls the rate of axial elongation of the eyeball to match the eye’s optical power. This emmetropization mechanism should result in eyes without refractive error. If the emmetropization mechanism is disrupted, the result is an eye that is either too long (myopia) or too short (hyperopia) for its optics, producing blurred vision. Current research is aimed at identifying and characterizing the gene- and protein-level changes that underlie this emmetropization mechanism.

Publications –

Papers

Gao H, Frost MR, Siegwart JT, Jr. and Norton TT (2011) Patterns of mRNA and protein expression during minus-lens compensation and recovery in tree shrew sclera. Molecular Vision. 17, 903-919.

Frost MR and Norton TT (2007) Differential protein expression in tree shrew sclera during development of lens-induced myopia and recovery. Molecular Vision. 13, 1580-1588.

Frost MR and Guggenheim JA (1999) Mammalian polyadenylation sites: Implications for differential display. Nucleic Acids Research. 27, 1386-1391.

Frost MR and Guggenheim JA (1999) Prevention of depurination during elution facilitates the reamplification of DNA from differential display gels. Nucleic Acids Research. 27, e6.