Lawrence J. DeLucas, O.D., Ph.D.

DEPARTMENT OF OPTOMETRY


Lawrence James DeLucas, O.D., Ph.D.

Professor, Optometry

Contact Information:
Office - (205) 934-5329 or 934-0550

Physical Address:
100 Center for Biophysical Sciences & Engineering
1025 18th Street South

Mailing Address:
CBSE 100
1530 Third Avenue South
Birmingham, AL 35294-4400



Biographical Sketch:

Education:
1972 - University of Alabama at Birmingham, Birmingham, Alabama (B.S., Chemistry)
1974 - University University of Alabama at Birmingham, Birmingham, Alabama (M.S., Chemistry)
1979 - University University of Alabama at Birmingham, Birmingham, Alabama (B.S., Physiological Optics)
1981 - University University of Alabama at Birmingham, School of Optometry, Birmingham, Alabama (O.D.)
1982 - University University of Alabama at Birmingham, Department of Biochemistry, (Ph. D.)

Administrative Responsibilities:

Professor, Department of Optometry 
Director, Center for Biophysical Sciences and Engineering 
Director, Comprehensive Cancer Center X-ray Core Facility 
Senior Scientist, Comprehensive Cancer Center

Secondary Appointments:

2002-present Assistant Professor, School of Biomedical Engineering, University of Alabama at Birmingham
2002-present Sparkman Center Scholar, School of Public Health, University of Alabama at Birmingham
2001-present Adjunct Professor, Physiology and Biophysics, University of Alabama at Birmingham
1997-present Member, Government Relations Group, University of Alabama at Birmingham
1996-present Member, Center for Metabolic Bone Disease, University of Alabama at Birmingham
1990-present Adjunct Professor, Department of Biochemistry, University of Alabama at Birmingham
1990-present Adjunct Professor, Laboratory of Medical Genetics, University of Alabama at Birmingham
1989-present Professor, Department of Optometry, University of Alabama at Birmingham
1989-present Adjunct Professor, Materials Science, University of Alabama
1989-present Adjunct Professor, Materials Science, University of Alabama at Birmingham
1989-present Adjunct Professor, Materials Science, University of Alabama in Huntsville
1984-present Senior Scientist, Comprehensive Cancer Center, University of Alabama at Birmingham
1983-present Member, Graduate Faculty, University of Alabama at Birmingham
1982-present Senior Scientist, Research Center in Oral Biology, University of Alabama at Birmingham
1982-present Senior Scientist, Vision Science Research Center Faculty, University of Alabama at Birmingham

Scholarly Activity:

Teaching:
IBS-700, CELL AND PROTEIN BIOCHEMISTRY
BMG-734, PROTEIN STRUCTURE

Research:
Dr. DeLucas current research involves the study of membrane protein structure-function relationships. His laboratory has developed/validated a variety of novel technologies to support these studies, including technologies in protein expression, formulations development aimed at yielding more soluble and more stable protein, the use of predictive algorithms to support rapid determination of favorable protein crystallization conditions as well as ideal solutions for protein therapeutics. The lab is currently focused on the production, purification and crystallization of full-length cystic fibrosis transmembrane regulator protein (CFTR). The cystic fibrosis trans-membrane conductance regulator (CFTR) protein plays a key role in chloride conductance in normal airway cells. Single point mutations of CFTR can cause improper processing of the protein within epithelial cells or unresponsiveness to other interacting molecules important for CFTR activity. Dr. DeLucas's lab is also studying several G-protein coupled receptors (GPCRs) believed to play a critical role in prostate cancer.

Center for Biophysical Sciences and Engineering

Recent Publications:

McDonald, H.M., Pruet, P.S., Deivanayagam, C., Protasevich, I.I., Carson, W.M., Delucas, L.J., Brouillette, W.J., Brouillette, C.G. "Structural adaptation of an interacting non-native C-terminal helical extension revealed in the crystal structure of NAD(+) synthetase from Bacillus anthracis", Acta Crystallogr D Biol Crystallogr., Aug;63(Pt 8):891-905, 2007.

Rypniewski, W., Vallazza, M., Perbandt, M., Klussmann, S., DeLucas, L.J., Betzel, C., Erdmann, V.A. "The first crystal structure of an RNA racemate",
Acta Crystallogr D Biol Crystallogr., Jun;62(Pt 6):659-64, 2006.

Wu, Y., McCombs, D., Nagy, L., DeLucas, L.J., Sha, B. "Preliminary X-ray crystallographic studies of yeast mitochondrial protein Tom70p", Acta Crystallograph Sect F Struct Biol Cryst Commun., Mar 1;62(Pt 3):265-7, 2006.

Josyula, R., Jin, Z., McCombs, D., DeLucas, L.J., Sha, B. "Preliminary crystallographic studies of yeast mitochondrial peripheral membrane protein Tim44p",
Acta Crystallograph Sect F Struct Biol Cryst Commun., Feb 1;62(Pt 2):172-4, 2006.

Schormann N, Pal B, Senkovich O, Carson M, Howard A, Smith C, Delucas L, Chattopadhyay D. "Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor", J Struct Biol., Oct;152(1):64-75, 2005.