DEPARTMENT OF VISION SCIENCES
Om P. Srivastava, Ph.D.
Professor and Interim Chair, Vision Sciences
Office - (205) 975-7630
638 Worell Building
924 18th Street South
1530 Third Avenue South
Birmingham, AL 35294-4390
Ph.D. (1976) - University of Western Ontario Canada
M.S. (1968) - University of Allahabad India
School of Optometry Faculty Affairs Committee (SOFAC)
Vision Sciences Faculty Advisory Committee (VS-FAC)
Faculty Policy & Procedures Committee
Senior Scientist, Vision Science Research Center
Senior Scientist, Center for Aging, School of Medicine
Senior Scientist, Minority Health & Research Center, School of Medicine
PO 211 Physiology of the Eye (Coursemaster and lecturer). A professional level course in ocular physiology for 1st year optometry students.
VS 744 Anatomy, Physiology and Biochemistry of the Eye (Coursemaster and lecturer). A multi-track course in basic ocular science for graduate students registered in the Vision Science Program.
VS 745 Anatomy, Physiology and Biochemistry of the Eye. II (lecturer). Continuation of VS 744.
My research is directed towards understanding the lens protein modifications at the molecular level during aging and cataractogenesis. Specifically, we are examining the role of lens proteinases in the proteolysis of lens structural proteins i.e., crystallins, and the role of the proteolyzed crystallin fragments in vivo in aggregation and cross-linking of proteins during aging and cataractogenesis. These studies fall in the following four basic areas: 1) Activation of lens proteinases and their regulation by endogenous cognate inhibitors, 2) In vivo regulation of proteolysis of crystallins by endogenous proteinases, 3) Aggregation and cross-linking of crystallin fragments in vitro, and 4) Identification of aggregated and cross-linked species generated by crystallin fragments in vivo in aging and cataractous human lenses.
Human senile cataractogenesis is targeted in the above studies because it occurs in about 50% of the population over age 75. It is the second most frequent cause of existing and new cases of registered blindness. I have secondary interest in corneal endothelial membrane proteins.
Srivastava O.P. and Srivastava K., Characterization of a sodium deoxycholate-activatable proteinase activity associated with βA3/A1-crystallin of human lenses. Resubmitted revised version to Biochem. Biophys. Acta 1434: 331-346, 1999.
Srivastava O.P. and Srivastava K. cAMP-Dependent Phosphorylation of βig-h3 Protein in Human Corneal Endothelial Cells. Curr. Eye Res. 19:348-357, 1999.
Srivastava O.P. and Srivastava K. Age-related degradation of βA3/A1-crystallin in human lenses, Biochem. Biophys. Res. Commun. 258, 632-638, 1999.
Srivastava O.P. and Srivastava K., Degradation of עD- and עs-crystallins in human lenses, Biochem. Biophys. Res. Commun. 253; 288-294, 1998.
Srivastava O.P. and Srivastava K., Purification of ע-crystallin from human lenses by acetone solubilization method. Curr. Eye Res., 17; 1074-1081, 1998.
Previously Dr. Srivastava worked as a Research Associate at Purdue University and at the University of Missouri, Columbia, and as a Senior Research Scientist at the Missouri Lions Eye Research Foundation in Missouri.