K11020—Medicine - Atherosclerosis Research Unit

Mentor: Dr. Jere P. Segrest, Professor,  BDB 630 1530 3rd Avenue South, Birmingham, AL 35294-0012 Telephone: (205) 934-4070; Fax: (205) 975-8079; E-mail:segrest@uab.edu


A Postdoctoral Fellowship is available for a Physical Chemist/Biochemist/Structural Biologist to study detailed molecular structures of apolipoprotein (apo) A-I on high density lipoprotein (HDL). Focus is on pathways for in vivo assembly of cholesteryl ester (CE)-rich (spheroidal) HDL, including the structure/dynamics of phospholipid (PL)-poor (preß) and PL-rich (discoidal) HDL. The driving hypothesis is that apoA-I is a uniquely elastic lipid-clamp capable of absorbing PL and CE in increments of a few molecules at a time. Because of a recent demonstration by our lab of the power of MD simulations to provide supramolecular images of HDL, experimental approaches combined with MD simulations uniquely position us to gain fundamental new insights into the structure/function of HDL subspecies. Candidates should have obtained a Ph.D. degree within the past 3 years with a strong background in physicochemistry, biochemistry and structural biology. A highly motivated and independent scientist able to work within an interdisciplinary team is preferred. E-mail research summary, CV, and 3 references to: Jere P. Segrest: segrest@uab.edu 

Postdocs in UAB News

  • Stephen Carter will attend the Experimental Biology Conference in late March to receive his award.Stephen J. Carter, Ph.D., postdoctoral fellow in the University of Alabama at Birmingham Department of Human Studies and the Nutrition Obesity Research Center, has been awarded the American Physiological Society’s Environmental and Exercise Physiology (EEP) section Partnership for Clean Competition New Investigator Award. The award recognizes outstanding experimental research in environmental, exercise or thermal physiology by a postdoctoral fellow involving ergogenics and detection...

  • Poster sessions and guest lecturers celebrate Darwin’s legacy.To honor the 206th birthday of legendary evolutionary biologist Charles Darwin, the University of Alabama at Birmingham will host Darwin Day on Thursday, Feb. 12, and Friday, Feb. 13. The events will celebrate scientific research in evolutionary biology and other disciplines. “Charles Darwin’s great discovery, the principle of natural selection, is more relevant to science than ever before,” said Steven Austad, Ph.D., chair of the Department of Biology. “For...

UAB Research News

  • Guest speaker and former Surgeon General Regina Benjamin among many who will see new approaches and successful models of current health-disparities research.Mona FouadThe UAB Minority Health & Health Disparities Research Center (MHRC) will host the 2015 UAB Health Disparities Research Symposium, “The Science of Health Disparities: From Social Causes to Personalized Medicine,” March 17-18 in the DoubleTree by Hilton on 20th Street South in Birmingham. In its 10th year, the symposium highlights work by undergraduate,...

  • Previous research indicated six weeks of treatment improved hearing, but new findings published in the New England Journal of Medicine reveal six months is better.Babies treated for symptomatic cytomegalovirus (CMV) infection for six months, instead of the standard six weeks, have better hearing and developmental outcomes, according to a new study from the University of Alabama at Birmingham. One in 150 babies will be born with CMV, and about one of every five of those children...