K11020—Medicine - Atherosclerosis Research Unit


Mentor: Jere P. Segrest, M.D. Professor Mailing address: BDB 630 1530 3RD AVENUE S BIRMINGHAM AL 35294-0012 Telephone: (205) 934-4070 Fax: (205) 975-8079 E-mail :segrest@uab.edu

A Postdoctoral Fellowship is available for a Physical Chemist/Biochemist/Structural Biologist to study detailed molecular structures of apolipoprotein (apo) A-I on high density lipoprotein (HDL). Focus is on pathways for in vivo assembly of cholesteryl ester (CE)-rich (spheroidal) HDL, including the structure/dynamics of phospholipid (PL)-poor (preß) and PL-rich (discoidal) HDL. The driving hypothesis is that apoA-I is a uniquely elastic lipid-clamp capable of absorbing PL and CE in increments of a few molecules at a time. Because of a recent demonstration by our lab of the power of MD simulations to provide supramolecular images of HDL, experimental approaches combined with MD simulations uniquely position us to gain fundamental new insights into the structure/function of HDL subspecies. Candidates should have obtained a Ph.D. degree within the past 3 years with a strong background in physicochemistry, biochemistry and structural biology. A highly motivated and independent scientist able to work within an interdisciplinary team is preferred. E-mail research summary, CV, and 3 references to: Jere P. Segrest: segrest@uab.edu  or http://www.aru.uab.edu  

UAB News

  • A $4.76 million grant will support a team helping to identify ways to retain HIV-infected persons in care through a new Centre for Infectious Disease Research in Zambia study.Stephanie Topp, Ph.D., is a co-investigator and sole University of Alabama at Birmingham representative on a research team at the Centre for Infectious Disease Research in Zambia that has been awarded a $4.76 million grant from the Bill and Melinda Gates Foundation to support the Better Information for...

  • Blazer BEST contest participants learn about engineering and science principles while completing robot challenge.The University of Alabama at Birmingham School of Engineering is bringing together hundreds of middle and high school students from central Alabama to participate in a competition that will pit their unique robotic devices against one another. The event is hosted by Blazer BEST, or Boosting Engineering, Science and Technology, Robotics, Inc., the local chapter of the national nonprofit, volunteer-based BEST organization. BEST’s mission is to...