K11020—Medicine - Atherosclerosis Research Unit

Contact:

Mentor: Jere P. Segrest, M.D. Professor Mailing address: BDB 630 1530 3RD AVENUE S BIRMINGHAM AL 35294-0012 Telephone: (205) 934-4070 Fax: (205) 975-8079 E-mail :segrest@uab.edu


A Postdoctoral Fellowship is available for a Physical Chemist/Biochemist/Structural Biologist to study detailed molecular structures of apolipoprotein (apo) A-I on high density lipoprotein (HDL). Focus is on pathways for in vivo assembly of cholesteryl ester (CE)-rich (spheroidal) HDL, including the structure/dynamics of phospholipid (PL)-poor (preß) and PL-rich (discoidal) HDL. The driving hypothesis is that apoA-I is a uniquely elastic lipid-clamp capable of absorbing PL and CE in increments of a few molecules at a time. Because of a recent demonstration by our lab of the power of MD simulations to provide supramolecular images of HDL, experimental approaches combined with MD simulations uniquely position us to gain fundamental new insights into the structure/function of HDL subspecies. Candidates should have obtained a Ph.D. degree within the past 3 years with a strong background in physicochemistry, biochemistry and structural biology. A highly motivated and independent scientist able to work within an interdisciplinary team is preferred. E-mail research summary, CV, and 3 references to: Jere P. Segrest: segrest@uab.edu  or http://www.aru.uab.edu  

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UAB Research News

  • “Decoding a Hindu Temple: Royalty and Religion in the Iconographic Program of the Virupaksha Temple, Pattadakal” interprets the visual images and symbols of the temple.The first book by University of Alabama at Birmingham Associate Professor of Art History Cathleen Cummings, M.A., Ph.D., “Decoding a Hindu Temple: Royalty and Religion in the Iconographic Program of the Virupaksha Temple, Pattadakal,” has been published. Cummings is a faculty member in the UAB Department of Art and Art History, part of...

  • UAB researchers are investigating game-based verification that may improve computer security and reduce user frustration compared to typical “type-what-you-see” CAPTCHA tools that use static images.CAPTCHA services that require users to recognize and type in static distorted characters may be a method of the past, according to studies published by researchers at the University of Alabama at Birmingham. CAPTCHAs represent a security mechanism that is often seen as a necessary hassle by Web services providers — necessary...