K11020—Medicine - Atherosclerosis Research Unit

Mentor: Dr. Jere P. Segrest, Professor,  BDB 630 1530 3rd Avenue South, Birmingham, AL 35294-0012 Telephone: (205) 934-4070; Fax: (205) 975-8079; E-mail:segrest@uab.edu


A Postdoctoral Fellowship is available for a Physical Chemist/Biochemist/Structural Biologist to study detailed molecular structures of apolipoprotein (apo) A-I on high density lipoprotein (HDL). Focus is on pathways for in vivo assembly of cholesteryl ester (CE)-rich (spheroidal) HDL, including the structure/dynamics of phospholipid (PL)-poor (preß) and PL-rich (discoidal) HDL. The driving hypothesis is that apoA-I is a uniquely elastic lipid-clamp capable of absorbing PL and CE in increments of a few molecules at a time. Because of a recent demonstration by our lab of the power of MD simulations to provide supramolecular images of HDL, experimental approaches combined with MD simulations uniquely position us to gain fundamental new insights into the structure/function of HDL subspecies. Candidates should have obtained a Ph.D. degree within the past 3 years with a strong background in physicochemistry, biochemistry and structural biology. A highly motivated and independent scientist able to work within an interdisciplinary team is preferred. E-mail research summary, CV, and 3 references to: Jere P. Segrest: segrest@uab.edu 

Postdocs in UAB News

  • Increased risk of major adverse cardiac events after the later surgery persists for one year.Carla HolcombA patient who has noncardiac surgery sometime after a stent is put into a coronary artery to open up a blockage has a greater risk for major adverse cardiac events (MACE) following the operation, but the optimal time to delay such elective surgery after stenting was not known. In a study of more than 28,000 patient records, first author Carla Holcomb,...

  • UAB School of Public Health research published in the journal Obesity shows seeing, hearing and smelling others’ eating foods can cause low birthweight in offspring among mice.While studies have shown that what a mother eats during pregnancy can affect her offspring, it could be that what she sees others eating can also affect her offspring. New research from the University of Alabama at Birmingham School of Public Health explores the influence it has in a...

UAB Research News

  • Vision services backed by UAB’s Callahan Eye Hospital now available in Talladega and Sylacauga.The comprehensive vision care provided by UAB Medicine is now available in Sylacauga and Talladega. J. Waid Blackstone, M.D., has joined the University of Alabama at Birmingham Callahan Eye Hospital Clinic network of doctors and will see patients at clinics located in those communities. “I’m proud to join the UAB Callahan Eye Hospital Clinic,” Blackstone said. “I offer a local solution for advanced...

  • UAB researchers find a chemical pathway — a glutamate transporter — that may be causing seizures and shorten survival rates for patients with brain tumors.Researchers at the University of Alabama at Birmingham have identified a chemical pathway that may be associated with seizures and shorter patient survival in some patients with malignant glioma, the most common and deadly form of brain tumor. In findings published May 27 in Science Translational Medicine, the researchers suggest that...