K11020—Medicine - Atherosclerosis Research Unit

Mentor: Dr. Jere P. Segrest, Professor,  BDB 630 1530 3rd Avenue South, Birmingham, AL 35294-0012 Telephone: (205) 934-4070; Fax: (205) 975-8079; E-mail:segrest@uab.edu


A Postdoctoral Fellowship is available for a Physical Chemist/Biochemist/Structural Biologist to study detailed molecular structures of apolipoprotein (apo) A-I on high density lipoprotein (HDL). Focus is on pathways for in vivo assembly of cholesteryl ester (CE)-rich (spheroidal) HDL, including the structure/dynamics of phospholipid (PL)-poor (preß) and PL-rich (discoidal) HDL. The driving hypothesis is that apoA-I is a uniquely elastic lipid-clamp capable of absorbing PL and CE in increments of a few molecules at a time. Because of a recent demonstration by our lab of the power of MD simulations to provide supramolecular images of HDL, experimental approaches combined with MD simulations uniquely position us to gain fundamental new insights into the structure/function of HDL subspecies. Candidates should have obtained a Ph.D. degree within the past 3 years with a strong background in physicochemistry, biochemistry and structural biology. A highly motivated and independent scientist able to work within an interdisciplinary team is preferred. E-mail research summary, CV, and 3 references to: Jere P. Segrest: segrest@uab.edu 

Postdocs in UAB News

  • UAB School of Public Health research published in the journal Obesity shows seeing, hearing and smelling others’ eating foods can cause low birthweight in offspring among mice.While studies have shown that what a mother eats during pregnancy can affect her offspring, it could be that what she sees others eating can also affect her offspring. New research from the University of Alabama at Birmingham School of Public Health explores the influence it has in a...

  • Early palliative care offers statistically beneficial effects on patient survival and family caregiver burden, according to articles published in the Journal of Clinical Oncology.Two papers recently published by University of Alabama at Birmingham School of Nursing researchers in the Journal of Clinical Oncology highlight the need for a “culture shift” by clinicians and the general public to engage palliative care services long before a person reaches the final stage of life. Two articles reporting on 207...

UAB Research News

  • Money raised from the annual fundraiser goes toward research and scholarships in the SOO.The University of Alabama at Birmingham School of Optometry is hosting its annual Dean’s Community Advisory Committee golf tournament to benefit scholarships, research and renovations for the school at 11 a.m. Monday, April 27, at the Inverness Country Club, 1 Country Club Drive. This tournament has raised enough money to endow a $100,000 research fund and three $25,000 scholarships. Cost to participate for teams...

  • UAB will receive funding from the AHA over the next four years to complete projects in population health, clinical and basic science, focused on high blood pressure.The University of Alabama at Birmingham is one of four institutions selected to study high blood pressure as part of the American Heart Association’s new Strategically Focused Research Network on hypertension. The AHA will support the Strategically Focused Research Network on hypertension with an investment of $15 million over four years,...