K11020—Medicine - Atherosclerosis Research Unit

Mentor: Dr. Jere P. Segrest, Professor,  BDB 630 1530 3rd Avenue South, Birmingham, AL 35294-0012 Telephone: (205) 934-4070; Fax: (205) 975-8079; E-mail:segrest@uab.edu


A Postdoctoral Fellowship is available for a Physical Chemist/Biochemist/Structural Biologist to study detailed molecular structures of apolipoprotein (apo) A-I on high density lipoprotein (HDL). Focus is on pathways for in vivo assembly of cholesteryl ester (CE)-rich (spheroidal) HDL, including the structure/dynamics of phospholipid (PL)-poor (preß) and PL-rich (discoidal) HDL. The driving hypothesis is that apoA-I is a uniquely elastic lipid-clamp capable of absorbing PL and CE in increments of a few molecules at a time. Because of a recent demonstration by our lab of the power of MD simulations to provide supramolecular images of HDL, experimental approaches combined with MD simulations uniquely position us to gain fundamental new insights into the structure/function of HDL subspecies. Candidates should have obtained a Ph.D. degree within the past 3 years with a strong background in physicochemistry, biochemistry and structural biology. A highly motivated and independent scientist able to work within an interdisciplinary team is preferred. E-mail research summary, CV, and 3 references to: Jere P. Segrest: segrest@uab.edu 

Postdocs in UAB News

  • Deadlines for abstracts are set for early fall and are open to graduate students, postdoctoral fellows, clinical fellows and residents.Registration is open and abstracts are being accepted for the Comprehensive Cardiovascular Center symposium “Inflammation and Cardiovascular Disease,” which will be held Oct. 22-23 in the Renaissance Birmingham Ross Bridge Golf Resort and Spa. Sept. 1 is the deadline for abstracts to be considered for oral presentation and the Featheringill Young Investigator Award. Oct. 2 is the...

  • A national expert in the biomedical engineering field will chair UAB’s joint department beginning Oct. 1.Written by Kendra Carter Jianyi Zhang, M.D., Ph.D., a national leader in myocardial bioenergetics, biomaterial and stem cells for cardiac repair, has been named the chair of the University of Alabama at Birmingham’s Department of Biomedical Engineering, a joint department in the schools of Medicine and Engineering. Zhang will come to UAB from the University of Minnesota Medical School, where he is...

UAB Research News

  • A UAB researcher focusing on the epigenetics of drug abuse wins a significant funding award from the National Institutes of Health.Jeremy DayJeremy J. Day, Ph.D., assistant professor in the Department of Neurobiology at the University of Alabama at Birmingham, has been named one of six inaugural recipients of new research awards from the National Institute on Drug Abuse. The Avenir Award programs in HIV/AIDS and epigenetics are newly developed programs that reward early-stage investigators who...

  • Male and female mice use different immune cells to process chronic pain, indicating that different therapies for different genders could better target the problem.New research by University of Alabama at Birmingham researcher Robert Sorge, Ph.D., and team published today in Nature Neuroscience online challenges the common belief that males and females process pain in the same way. The majority of existing research shows that men and women have different sensitivity to pain — women are more...