K11020—Medicine - Atherosclerosis Research Unit

Mentor: Dr. Jere P. Segrest, Professor,  BDB 630 1530 3rd Avenue South, Birmingham, AL 35294-0012 Telephone: (205) 934-4070; Fax: (205) 975-8079; E-mail:segrest@uab.edu


A Postdoctoral Fellowship is available for a Physical Chemist/Biochemist/Structural Biologist to study detailed molecular structures of apolipoprotein (apo) A-I on high density lipoprotein (HDL). Focus is on pathways for in vivo assembly of cholesteryl ester (CE)-rich (spheroidal) HDL, including the structure/dynamics of phospholipid (PL)-poor (preß) and PL-rich (discoidal) HDL. The driving hypothesis is that apoA-I is a uniquely elastic lipid-clamp capable of absorbing PL and CE in increments of a few molecules at a time. Because of a recent demonstration by our lab of the power of MD simulations to provide supramolecular images of HDL, experimental approaches combined with MD simulations uniquely position us to gain fundamental new insights into the structure/function of HDL subspecies. Candidates should have obtained a Ph.D. degree within the past 3 years with a strong background in physicochemistry, biochemistry and structural biology. A highly motivated and independent scientist able to work within an interdisciplinary team is preferred. E-mail research summary, CV, and 3 references to: Jere P. Segrest: segrest@uab.edu 

Postdocs in UAB News

  • Early palliative care offers statistically beneficial effects on patient survival and family caregiver burden, according to articles published in the Journal of Clinical Oncology.Two papers recently published by University of Alabama at Birmingham School of Nursing researchers in the Journal of Clinical Oncology highlight the need for a “culture shift” by clinicians and the general public to engage palliative care services long before a person reaches the final stage of life. Two articles reporting on 207...

  • Tollefsbol will donate the $5,000 award to a graduate student award fund.A biology professor in the College of Arts and Sciences has been awarded the 2015 Caroline P. and Charles W. Ireland Prize for Scholarly Distinction as a result of the quality of his scholarship and impact on his field. Trygve Tollefsbol, Ph.D., a professor in the College of Arts and Sciences Department of Biology, is a leader in the growing field of epigenetics. Tollefsbol is...

UAB Research News

  • Students in the Department of Art and Art History’s Photography in the South course curated “Inherited Scars: A Meditation on the Southern Gothic,” from the Birmingham Museum of Art’s collection.Birney Imes, "Prairie Chapel Baptism," 1980, Collection of the Birmingham Museum of ArtA new show of photographs made in and about the South curated by students from the University of Alabama at Birmingham will open at the Birmingham Museum of Art on Thursday, April 2, for...

  • The runx2 master transcription factor functions differently in chondrocytes and osteoblasts, two key cells in bone formation.Amjad Javed and Haiyan Chen examine the effect of a runx2 deletion on bone mineralization. Amjad Javed, Ph.D., of the University of Alabama at Birmingham, has taken a major step forward in understanding the bone development function of a gene called runx2, which could lead to future ways to speed bone healing, aid bone bioengineering, stem osteoporosis and reduce...