Immunogenetics and Functional Genomics
Research opportunities are available in cellular and molecular immunology, emphasizing genetic variation of immune response genes and the impact on immune system function, including the predisposition to autoimmune and immune-mediated inflammatory diseases and the characteristics of host responses to infectious agents. Both human and non-human model systems form the basis for study.
The primary emphasis of the program is the identification and understanding of naturally occurring, genomically encoded variants of immune response genes. Mentors are involved in both their own research programs and in the care of patients with autoimmune and immune-mediated inflammatory diseases, thus providing an opportunity for translational work between model systems and human immunology. Opportunities in human biology and disease are available in autoimmune and immune-mediated inflammatory diseases, malignant diseases, host-defense defense including vaccine development, and transplantation immunology. Outstanding investigator-based and core-based facilities are available. Resources include state-of-the-art high-speed flow cytometry, high resolution imaging (confocal, FRET, standard and cryo-election microscopy), nucleic acid and protein sequencing, hybridoma/phage display antibody production, and transgenic/ES cell mouse facilities.