F13200 - Medicine/Infectious Diseases

Mentor: Dr. Frank Wolschendorf, Assistant Professor, Department of Medicine/Infectious Diseases, University of Alabama at Birmingham, BBRB512, 845 19th Street South, Birmingham, AL 35294.  Telephone: (205) 975-2760; Email: fwolsche@uab.edu

A Postdoctoral position in the Department of Medicine/Infectious Diseases at the University of Alabama at Birmingham is available immediately as part of an NIH funded project. Our research is focused on the identification and characterization of small molecule inhibitors that act by novel mechanisms against multi-drug resistant bacterial pathogens including Mycobacterium tuberculosis or Staphylococcus aureus.

The innate immune system utilizes a variety of strategies to kill bacterial intruders, one of which is exposing microbes to copper ions. Copper ions accumulate specifically at the site of infection and pose a significant threat to bacterial pathogens. Thus, bacteria have evolved a variety of mechanisms to alleviate copper toxicity (PNAS: PMID 21205886).

We seek to identify compounds that enhance the antibacterial properties of copper (AAC: PMID 23254420) and thereby act in synergy to copper-dependent innate immune functions of the host. Objectives include the design and development of a novel high-throughput platform, performing automated pilot screens, the development and implementation of secondary assays for hit prioritization, and in vivo studies detailing the mode of action by which these compounds elicit their antibacterial properties.

The applicant should have a strong background in microbiology, biochemistry or related field with relevance to this project.

Applications should be submitted by email as a single PDF document that includes a cover letter, a comprehensive CV and 3 references.

Requests for further information and applications should be addressed to: Dr. Frank Wolschendorf, phone: (205) 975-2760

Postdocs in UAB News

  • Increased risk of major adverse cardiac events after the later surgery persists for one year.Carla HolcombA patient who has noncardiac surgery sometime after a stent is put into a coronary artery to open up a blockage has a greater risk for major adverse cardiac events (MACE) following the operation, but the optimal time to delay such elective surgery after stenting was not known. In a study of more than 28,000 patient records, first author Carla Holcomb,...

  • UAB School of Public Health research published in the journal Obesity shows seeing, hearing and smelling others’ eating foods can cause low birthweight in offspring among mice.While studies have shown that what a mother eats during pregnancy can affect her offspring, it could be that what she sees others eating can also affect her offspring. New research from the University of Alabama at Birmingham School of Public Health explores the influence it has in a...

UAB Research News

  • Patients awaiting liver transplant who have primary biliary cirrhosis (PBC) had higher wait-list mortality compared with other patients on the liver transplant list, said researchers.

  • Stylish but dangerous? UAB study looks at injuries caused by wearing high-heeled shoes.Americans love high-heeled shoes. One survey in 2003 reported that 62 percent of American women wore shoes with a 2-inch or greater heel on a regular basis. Those shoes are taking a toll. New research from the University of Alabama at Birmingham shows that high-heeled-shoe-related injuries doubled between 2002 and 2012. The findings were published online May 12 in the Journal of Foot and...