F13200 - Medicine/Infectious Diseases

Mentor: Dr. Frank Wolschendorf, Assistant Professor, Department of Medicine/Infectious Diseases, University of Alabama at Birmingham, BBRB512, 845 19th Street South, Birmingham, AL 35294.  Telephone: (205) 975-2760 Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

A postdoctoral position in the Department of Medicine/Infectious Diseases at the University of Alabama at Birmingham is available immediately as part of an NIH funded project. Our research is focused on the identification and characterization of small molecule inhibitors that act by novel mechanisms against multi-drug resistant bacterial pathogens including Mycobacterium tuberculosis or Staphylococcus aureus.

The innate immune system utilizes a variety of strategies to kill bacterial intruders, one of which is exposing microbes to copper ions. Copper ions accumulate specifically at the site of infection and pose a significant threat to bacterial pathogens. Thus, bacteria have evolved a variety of mechanisms to alleviate copper toxicity (PNAS: PMID 21205886).

We seek to identify compounds that enhance the antibacterial properties of copper (AAC: PMID 23254420) and thereby act in synergy to copper-dependent innate immune functions of the host. Objectives include the design and development of a novel high-throughput platform, performing automated pilot screens, the development and implementation of secondary assays for hit prioritization, and in vivo studies detailing the mode of action by which these compounds elicit their antibacterial properties.

The applicant should have a strong background in microbiology, biochemistry or related field with relevance to this project.

Applications should be submitted by email as a single PDF document that includes a cover letter, a comprehensive CV and 3 references.

Requests for further information and applications should be addressed to: Dr. Frank Wolschendorf, phone: (+1) 205-975-2760

UAB News

  • "We have a broader array of workers than you'd see in other cities, from hourly employees in mining and manufacturing to CEOs of biotech firms," says Jack Howard, Ph.D., associate dean at the University of Alabama at Birmingham's Collat School of Business. "It's a laid-back culture, but there's a very strong work ethic."

  • There are a lot of regimens being tried in transplant, and most include calcineurin inhibitors that have significant toxicity," Anupam Agarwal, MD, of the University of Alabama at Birmingham, told MedPage Today. "Hence, if one could safely reduce the dose of the calcineurin inhibitor and still benefit from its immunosuppressive properties, it would be huge advance."

UAB Research News

  • Shirey, who will be inducted in September, is nationally recognized for her innovative integration of teaching and learning strategies.Maria R. Shirey, Ph.D., professor and assistant dean for Clinical Affairs and Partnerships in the University of Alabama at Birmingham School of Nursing, has been selected for induction as a fellow into the National League for Nursing Academy of Nursing Education. Shirey is nationally recognized for her innovative integration of teaching and learning strategies using research, evidence-based practice...

  • The Quad Rider makes it easy to shift gears and brake, enabling people with poor grip-control to safely cycle.The University of Alabama at Birmingham and the Lakeshore Foundation are partnering with InvoTek, Inc., to create a gear and braking device that helps people with disabilities who have limited or no use of their hands operate a handcycle safely. InvoTek, a research and development company in Alma, Arkansas, has received a $175,000 Phase I Small Business Innovation...