Mentor: Ganesh V Halade, PhD, Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham located at 703, 19th Street South, ZRB 310A, Birmingham, AL 35294-0007 Telephone: (205) 996-4139 Fax: (205) 975-5150 E-mail: halade@uab.edu

 

A postdoctoral position is available for a highly motivated individual in the Department of medicine, division of cardiovascular disease for studies of inflammation and extracellular matrix after heart attack in the setting of obesity. Studies will focus on neutrophils, monocytes, macrophages and fibroblast to interrogate cell-signaling mechanisms in primary cells by molecular biology. Mechanistic studies will be coupled with tests of physiological measurements after surgically inducing myocardial infarction in a survival mouse model. Current translational research experiments will be assayed by inflammatory and extracellular matrix array, molecular biology, histology and immunohistochemistry. Surgical, echocardiography, and histology skills are not immediately required, but essential can be learned during the course of studies. A fundamental training in molecular biology is required. The successful candidate will employ in vitro and in vivo models to examine the roles of fatty acids in post-myocardial infarction inflammation and cardiac remodeling in the setting of obesity. Responsibilities will include maintenance of complete laboratory records and execution of experimental procedures, preparation of manuscripts and presentations at internal and national meetings as required.

Qualification: The applicants must have a Ph.D. in biomedical science or other related disciplines, with strong background/expertise in one or more of the following areas: molecular biology, cell biology, and cardiac physiology. Expertise in cell culture are highly desirable, handling of laboratory animals, minor animal surgery are beneficial, but not necessary. Expertise with basic techniques utilizing DNA, RNA, protein, and tissue culture is required. Candidate need to demonstrate independence and the ability to communicate.

If interested please send a CV, names of three references, and a description of research interests and career goals (1 page) to: Elizabeth A Richards at richarde@uab.edu

Or Contact

Ganesh V Halade, PhD, Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham located at 703, 19th Street South, ZRB 310A, Birmingham, AL 35294-0007 Telephone: (205) 996-4139 Fax: (205) 975-5150 E-mail: halade@uab.edu

Consideration of applications will continue until the position is filled. The University of Alabama at Birmingham is an Equal Opportunity/Affirmative Action Employer and encourages applications from qualified women and minorities.

 

Postdocs in UAB News

  • NIH awards nearly $34 million to UAB Center for Clinical and Translational Science
    This renewing of UAB’s prestigious Center for Translational Science Award will bolster research and workforce development at UAB and throughout its regional partner network in the Southeast.

    Written by Christina Crowe

    The National Institutes of Health has awarded the University of Alabama at Birmingham Center for Clinical and Translational Science $33.59 million over four years to continue the center’s programs advancing translational research.

    Since its initial funding in 2008 through Alabama’s only Center for Translational Science Award to work toward innovative discoveries for better health, the UAB CCTS has nurtured UAB research, accelerating the process of translating laboratory discoveries into treatments for patients, training a new generation of clinical and translational researchers, and engaging communities in clinical research efforts.

    The CCTS will continue to advance its mission to accelerate the delivery of new drugs, methodologies and practices to patients at UAB and throughout a partner network of 11 institutions in the Southeast.

    “We are excited by the capacity to continue to enhance our institution’s and our region’s innovative research and medical care,” said Robert Kimberly, M.D., UAB CCTS director. “Through internal and external partnerships, as well as a robust clinical environment and cutting-edge informatics and clinical trial resources, we look forward to working with our patients over the course of their lifespan.”

    Congress launched the CTSA program in 2006, which is overseen by the National Center for Advancing Translational Sciences.

    The amount of this award, more than double its previous funding awarded in 2008 and one of the largest at UAB, reflects an unmatched enthusiasm for the CCTS and its affiliated programs. It includes funding for 10 annual pre-doctoral training awards, 10 summer training awards, and eight career development awards for senior postdoctoral fellows or faculty-level candidates.

    “Our training programs continue to foster a culture of responsible, ethical practice among students, faculty and clinicians conducting human subjects research,” Kimberly said. “The NIH’s support of our expansive partner network, encompassing 11 regional academic and medical institutions throughout Alabama, Louisiana and Mississippi, will allow us to further grow our scope of practices and research resources as we look to tackle health disparities in the Southeast.”

    Through One Great Community, the CCTS’ community engagement enterprise, and the Community Health Innovation Awards, the CCTS engages Greater Birmingham­­-area residents in innovative programs designed by community members to improve their neighborhoods.

    “UAB is fully committed to the goals of the CCTS and to its continued development as a hub for clinical and translational research in the Southeast,” said UAB President Ray L. Watts. “This significant renewal speaks to the tremendous work and vision of our CCTS leadership and team, as well as our clinical infrastructure, scientific strengths, informatics expertise, training programs, and biostatistical and research design assistance.

    “The CCTS touches researchers in all UAB schools and across the partner network, and we are thrilled that this important work will continue with the confidence and support of the NIH.”

    Click to enlargeState and regional impact

    “The growth of the Center for Clinical and Translational Science at UAB will foster economic development in the state and throughout the region,” said Senator Richard Shelby. “With a history of providing optimal clinical care and innovation in human health, UAB’s receipt of this prestigious award enables the continued development of the workforce that is necessary to meet the needs of future research advancement.”

    Alabama Governor Robert Bentley, himself a physician, voiced his appreciation for the CCTS’ initiatives. “The center has been highly effective in providing assistance in the state’s efforts to eliminate the health disparities seen throughout our region,” Bentley said. “Whether across the life course or in underserved groups disproportionately affected by cancer, stroke, heart conditions and other diseases prevalent in our state, the center has been exemplary in reaching out to our citizens.”

    UAB Vice President, Research and Economic Development Richard Marchase, Ph.D., says he is particularly pleased that the CCTS is building on UAB’s history of serving populations burdened by health disparities through its partnerships with other state and regional institutions committed to advancing health through translational research. “It is through this culture of commitment and collaboration,” he said, “that we have become a national leader in biomedical research.”

  • UAB names McMahon dean of Graduate School
    Lori McMahon, Ph.D., will enrich excellence and innovation in graduate education through professional and career-development initiatives and lead collaborative efforts for recruitment and outreach with various academic units to attract highly qualified students.

    Lori McMahon, Ph.D., has been named dean of the Graduate School at the University of Alabama at Birmingham following a national search guided by a 13-member committee made up of students, faculty and staff, and chaired by UAB Vice President for Research and Economic Development Richard Marchase, Ph.D.

    Marchase says the search committee was very pleased with both the size and the strength of the applicant pool, especially those candidates from within UAB, and that the committee is exceptionally pleased McMahon will serve as UAB’s Graduate School dean.

    “There were several candidates who really stood out, and among those Lori was a clear choice of the committee,” he said. “Her extensive experience in graduate education, her innovative approaches to how graduate education can be improved, and her enthusiastic ability to interface with both prospective and current students were distinguishing factors.”

    McMahon will strive to enrich excellence and innovation in graduate education through professional and career-development initiatives and lead collaborative efforts for recruitment and outreach with various academic units to attract highly qualified students. She also will monitor the academic status of students and provide support and oversight for administrative functions within the Graduate School. McMahon will report directly to the provost and will work closely with deans in all academic areas.

    “Her extensive experience in graduate education, her innovative approaches to how graduate education can be improved, and her enthusiastic ability to interface with both prospective and current students were distinguishing factors.”

    “Dr. McMahon has a reputation for working well with faculty across our very broad and diverse enterprise, and she has a real passion for mentoring doctoral students,” said UAB Provost Linda Lucas. “She always has doctoral students in her lab. She will bring an energy and dedication to this position that will have far-reaching benefits for students, faculty and staff.”

    A current UAB professor of cell, developmental and integrative biology, McMahon is also the Jarman F. Lowder Professor of Neuroscience and director of the UAB Comprehensive Neuroscience Center. She is associate director of the Evelyn F. McKnight Brain Research Institute, is associate director for the Comprehensive Center for Healthy Aging, and also holds appointments in the Alzheimer’s Disease Center, Civitan International Research Center and the Center for Exercise Medicine.

    “I have been fortunate since joining UAB in 1998 to work in a tremendously collaborative environment among outstanding faculty committed to developing highly educated trainees with the knowledge and integrity to go out and change the world,” McMahon said. “I am honored and humbled to be the dean of the Graduate School and look forward to working with faculty and students from disciplines across campus to build upon our growing prominence as a world-renowned research university.”

    McMahon — who earned her Ph.D. in neuropharmacology from Saint Louis University Health Sciences Center — joined the faculty at UAB in 1998 as an assistant professor in the Department of Physiology and Biophysics after completing her postdoctoral training at Duke University Medical Center. She is a member of the Society for Neuroscience, American Physiological Society, and International Society to Advance Alzheimer’s Research and Treatment.

    “I would like to thank the search committee for their commitment to identifying an exceptional candidate for this job,” said UAB President Ray L. Watts. “Thanks to the time and thoughtful consideration of many students, faculty, staff and supporters over many months, UAB has welcomed terrific new leadership in many areas across campus, and I am pleased Dr. McMahon will take on this important role as we strive to maximize the reach and effectiveness of UAB’s world-class graduate education opportunities.”

    Associate Dean Jeffrey Engler, Ph.D., has been interim dean of the Graduate School at UAB during the search for a permanent candidate to fill the vacancy created by the Dec. 31, 2014, retirement of Bryan Noe, Ph.D., who was UAB’s first full-time Graduate School deanfrom 2005 to 2014.

    UAB’s graduate enrollment, up 43 percent in the past decade, is the highest among Alabama universities, at 5,937 in fall 2014. The diverse group, which is two-thirds female and nearly 30 percent minority, is pursuing degrees in 50 master’s programs, 37 doctoral programs and eight education specialist programs.

    McMahon’s first day as dean will be Oct. 1.

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UAB Research News

  • Crowdsourcing science: How Amazon’s Mechanical Turk is becoming a research tool
    A growing number of researchers, from computer scientists to philosophers, are taking an interest in the "artificial artificial intelligence" offered by Amazon's microwork platform.

    Written by Matt Windsor

    This spring, Chris Callison-Burch, Ph.D., was in town to share an unusual approach to machine learning. This is one of the hottest topics in computer science: It is behind everything from Google’s self-driving cars to Apple’s Siri personal assistant.

    Callison-Burch, an assistant professor at the University of Pennsylvania, is building a system that can automatically translate foreign languages into English — especially obscure dialects (from an American point of view) that can be of great interest to national security. He was in Birmingham at the invitation of Steven Bethard, Ph.D., a machine learning researcher and assistant professor in the UAB College of Arts and Sciences Department of Computer and Information Sciences.

    In order to teach a computer to do something, Callison-Burch explained, you need to give it examples. Lots of examples. For a French-English translation, there are millions of sample texts available on the Internet. For Urdu, not so much.

    Crowdsourced corpus

    One way around this problem would be to pay professional translation services thousands of dollars to create the “corpus” of words you would need to train a computer to translate Urdu automatically. Callison-Burch has pioneered another approach: He paid some random folks on the Internet a few bucks at a time to do the work instead.

    Callison-Burch is one of a growing number of researchers using Amazon Mechanical Turk, a service of the giant Internet company that bills itself as a “marketplace for work.” Mechanical Turk, or MTurk, as it is known, “has almost become synonymous with crowdsourcing,” Callison-Burch said. Anyone in need of help with a “human intelligence task” (Amazon’s term) can post a job description, and the “reward” they are willing to pay. One recent afternoon, some of the 255,902 tasks available on MTurk included tagging photos on Instagram (4 cents per picture), typing out the text visible in distorted images (1 cent per image) and rating test questions for a biology exam for a researcher at Michigan State University (a penny per question — this is a popular price point).

    Callison-Burch started out by giving Turkers and professional translators the same tasks. He encountered some trouble at first — respondents copying and pasting their assigned sentences into Google Translate, for example. “Quality control is a major challenge,” Callison-Burch said. “It is important to design tasks to be simple and easy to understand.”

    In order to teach a computer to do something, you need to give it examples. Lots of examples.
    That’s where Mechanical Turk can shine.

    So he tweaked his assignments to filter out people who weren’t really native speakers, and added in some clever quality control mechanisms, such as getting additional Turkers to pick the best translations out of multiple versions of the same sentence. Callison-Burch was able to get remarkably close to the professional quality, for “approximately an order of magnitude cheaper than the cost of professional translation,” he said.

    Turk-powered translation could be particularly helpful in translating regional Arabic dialects, Callison-Burch noted. “Because standard machine translation systems are trained on written text, they don’t handle spoken language well,” he said. In a recent study, Callison-Burch and his collaborators found that “comments on Arabic newspaper websites were written in dialect forms about 50 percent of the time.” A machine learning system trained in these dialects could offer vital clues about where a writer is from in the Middle East, for example, or about “his or her informal relationship with an interlocutor based on word choice.”

    Applications from obesity to philosophy

    MTurk’s brand of “artificial artificial intelligence” (Amazon’s Turk tagline) could also be applied to other machine learning research at UAB, notes Steven Bethard. “Chris’ work is fascinating,” with applications from medicine to the social sciences, Bethard said.

    UAB researchers are already putting MTurk to use. Andrew Brown, Ph.D., a research scientist in the Office of Energetics in the School of Public Health, has tested Turkers’ ability to categorize biomedical research studies. “We like to do some creative looks at what’s been published and how,” Brown said. For arecent paper, Brown and colleagues were interested in systematically evaluating nutrition-obesity studies. They wanted to find out whether studies with results that coincide with popular opinion are more likely to draw attention in the scientific community than studies that contradict the conventional wisdom. (They used citations as a proxy for the scientific community’s opinion of a paper.)  

    The first step was to identify all the studies of interest. But “the problem is, there are 25 million papers in PubMed, and sometimes the keywords don’t work very well,” Brown said. “It helps to have a human set of eyes take a look at it.” Instead of giving Ph.D.-level scientists the job, the researchers turned to MTurk. The Turkers successfully evaluated abstracts to identify appropriate studies and categorize the studied foods, then gathered citation counts for the studies in Google Scholar. (There was no significant link between public and scientific opinion when it came to the papers.)

    “We found it to be useful,” Brown said. “Expecting a perfect rating or an exhaustive rating from microworkers is probably a little premature, but on the other hand even trained scientists make mistakes.” Brown plans to use crowdsourcing for future studies. “This is just one more tool to add to our research toolbox,” he said.

    Josh May, Ph.D., an assistant professor in the UAB College of Arts and Sciences Department of Philosophy, has been using MTurk for several years — asking Turkers to solve thorny moral dilemmas. “I present participants with hypothetical scenarios and ask them to provide their opinion about them — ‘Did the person act wrongly?’” May said. “Then I see whether responses change when the scenarios are slightly different, e.g., when a harm is brought about actively versus passively, or as a means to a goal versus a side effect. Statistical analysis can reveal whether the differences are significant — providing evidence about whether the slight changes to the scenarios make a real difference in everyday moral reasoning.”

    “Expecting a perfect rating or an exhaustive rating from microworkers is probably a little premature, but on the other hand even trained scientists make mistakes…. This is just one more tool to add to our research toolbox.” —Andrew Brown, Ph.D.

    Social justice and microwork

    May, Brown and Callison-Burch share an interest in social justice for Turkers as well. “The main ethical issue with MTurk is exploitation,” May said. “The going rate is often around a quarter for a few minutes of work, which typically adds up to less than the federal minimum wage, even when working quickly. This apparently isn’t illegal given certain loopholes, but that doesn’t make it moral. Just because someone will work for pennies doesn’t mean we should withhold a living wage.”

    May’s solution for his own research “is to estimate the time it will take most workers to complete the task and then pay them enough so that the rate would amount to at least minimum wage.” Brown takes a similar approach — and when the Turkers work more slowly than expected, which drives down their overall wage, “there are bonus systems in place where you can give them something extra,” he said.

    Callison-Burch is using his programming skills to help Turkers earn fair wages. He has created a free browser extension (available at crowd-workers.com) that identifies high-paying jobs and makes it easier to identify job posters who have a large number of complaints.

    Crowdsourcing operations such as MTurk represent an untapped resource for scientists of all stripes, Callison-Burch concluded. “Individual researchers now have access to their own data production companies,” he said. “Now we can get the data we need to solve problems.”

  • Grants available for community health projects
    UAB’s Community Health Innovation Awards available to fund local projects aimed at community health issues.

    Grants ranging from $5,000 to $25,000 are available from the University of Alabama at Birmingham Community Health Innovation Awards, part of the One Great Community program. The awards will be given to local individuals and organizations that have good ideas for solving community health issues.

    The Community Health Innovation Awards’ annual grant competition is a way for participants to think boldly and creatively about solutions to health challenges communities face. The awards are a way for UAB, local leaders and area communities to share resources and expertise.  

    One Great Communityis the community engagement component ofUAB’s Center for Clinical and Translational Science. Its goal is to connect basic science and clinical researchers with the multiple communities in the state and region. This collaboration will ensure that research efforts respond to and reflect the needs of the community through an active process of community involvement, dialogue and mutual understanding.  

    All applicants for a 2015 CHIA grant must attend an innovation workshop Saturday, Sept. 19. Click here for registration information for the workshop.

    Draft proposals will be due Monday, Oct. 19, by 5 p.m., and final proposals will be due Monday, Nov. 16 by 5 p.m.

    For more information, please contact the CHIA Project Team at: chiateam2015@gmail.com.

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