B14006 - Department of Chemistry

Mentor:  Margaret Johnson, PhD, Assistant Professor, Department of Chemistry, University of Alabama at Birmingham, CHEM 274, 1720 2nd Avenue South, Birmingham, AL 35294-1240, (205) 934-8137, (205) 934-2543 fax

Postdoctoral Fellowship in Protein Structure and Function

A post-doctoral fellowship is available at the University of Alabama at Birmingham in the laboratory of Dr. Margaret Johnson. We use solution NMR spectroscopy and other biophysical techniques to investigate the structure and function of proteins involved in the metabolism and molecular recognition of poly(ADP-ribose), a key biomolecule in the maintenance of genome integrity, chromatin structure, and the cell cycle. Areas of research include determining high-resolution structures of proteins and protein complexes, enzymatic synthesis and computational simulations.

Our laboratory is part of the Comprehensive Cancer Center and Center for Structural Biology at UAB. The Central Alabama High-Field NMR Facility is equipped with Bruker 850, 700, 600 and 500 MHz spectrometers with TCI cryoprobes. Biophysics facilities include MALDI-TOF mass spectrometry, fluorescence spectroscopy, analytical ultracentrifugation, titration calorimetry, high-throughput screening and protein crystallization, and high-performance computing.

UAB is the top university and 8th overall institution in the Best Places to Work (Postdocs) survey published in The Scientist (2013). The campus is a major part of the downtown landscape, and is within walking distance of some of the best parks, entertainment and dining in the region. We offer high-quality training and mentoring, pay and benefits, career development, networking, and opportunities for family and personal life. The Office of Postdoctoral Education offers classes in grant writing, laboratory management, research ethics, and teaching and presentation skills. Interdisciplinary research seminars are ongoing in a variety of university-wide interest groups.

Enthusiastic, motivated researchers are encouraged to apply. Candidates should have recently received a Ph.D. in a related discipline and have a strong background in structural biology or biochemistry. To apply please send a cover letter, CV, and contact information for three references to Dr. Margaret Johnson at maggiejohnson@uab.edu. UAB is an equal opportunity/affirmative action employer.

 

 

 

 

 

 

 

 

UAB News

  • From Birmingham Medical News Michael Saag, MD came to Birmingham in 1981 to begin his residency in internal medicine at UAB with plans become a cardiologist. A few days after arriving in the city, the U.S. Centers for Disease Control reported eight cases of “unusual opportunistic infections” in gay men. The discovery of Acquired Immune Deficiency Syndrome (AIDS) soon sent Saag down a career path he never imagined.

  • Art Tipton plans to continue SRI’s work in drug development, the defense world and clean energy, while also increasing collaboration with UAB and boosting commercialization efforts from the research that takes place at the institute.

UAB Research News

  • UAB researchers are investigating game-based verification that may improve computer security and reduce user frustration compared to typical “type-what-you-see” CAPTCHA tools that use static images.CAPTCHA services that require users to recognize and type in static distorted characters may be a method of the past, according to studies published by researchers at the University of Alabama at Birmingham. CAPTCHAs represent a security mechanism that is often seen as a necessary hassle by Web services providers — necessary...

  • UAB Distinguished Professor’s editorial highlights research efforts exploring low-sodium intake guidelines and implications on cardiac disease and mortality.Recent studies suggest national dietary guidelines for sodium intake are unrealistic, and that the recommended level of sodium could be associated with a higher risk of cardiac disease and mortality. In an invited New England Journal of Medicine editorial, “Low Sodium — Cardiovascular Health Benefit or Risk?” University of Alabama at Birmingham Distinguished Professor of Medicine Suzanne Oparil, M.D.,...