D221402 - Microbiology

Mentor:  Dr. Hubert M. Tse, 
Assistant Professor, Department of Microbiology, Comprehensive Diabetes Center, University of Alabama at Birmingham, SHEL 1202, 1825 University Boulevard, Birmingham, AL 35294. Email:  htse@uab.edu

A Postdoctoral position is available in the laboratory of Hubert Tse in the Department of Microbiology, Comprehensive Diabetes Center, at the University of Alabama at Birmingham. Our research examines the role of oxidative stress on autoimmune responses in Type 1 diabetes (T1D). Through the use of novel immunotherapeutics and murine models of T1D, we can determine how reactive oxygen species (ROS) synthesis contributes to innate immune responses and autoreactive T cell effector mechanisms involved in pancreatic beta-cell destruction (Padgett et al. NY Annals, 2013).

We seek a motivated, creative, and energetic applicant to define the role of ROS synthesis on anti-viral responses to diabetogenic viral triggers (Coxsackievirus) of T1D in both murine models and human translational studies. The laboratory uses immunological methods, molecular biology, cellular biochemistry, redox biology, murine models of T1D, microscopic imaging, and flow cytometry to discover and evaluate new mechanisms of autoimmune dysregulation.

Candidates must have a recent Ph.D. and/or M.D., or equivalent. Priority will be given to qualified candidates with a strong background in immunology, molecular biology, biochemistry, flow cytometry, and diabetes-related research. Experience with mice is also preferred, but not required. Salary will follow NIH guidelines commensurate with training and experience. Competitive applicants will have a proven track record in terms of publications and independent funding.

If interested, please send a letter describing your research experience/interest/future career aspirations, your CV, and contact information for three references electronically to: htse@uab.edu

Postdocs in UAB News

  • Increased risk of major adverse cardiac events after the later surgery persists for one year.Carla HolcombA patient who has noncardiac surgery sometime after a stent is put into a coronary artery to open up a blockage has a greater risk for major adverse cardiac events (MACE) following the operation, but the optimal time to delay such elective surgery after stenting was not known. In a study of more than 28,000 patient records, first author Carla Holcomb,...

  • UAB School of Public Health research published in the journal Obesity shows seeing, hearing and smelling others’ eating foods can cause low birthweight in offspring among mice.While studies have shown that what a mother eats during pregnancy can affect her offspring, it could be that what she sees others eating can also affect her offspring. New research from the University of Alabama at Birmingham School of Public Health explores the influence it has in a...

UAB Research News

  • Patients awaiting liver transplant who have primary biliary cirrhosis (PBC) had higher wait-list mortality compared with other patients on the liver transplant list, said researchers.

  • Stylish but dangerous? UAB study looks at injuries caused by wearing high-heeled shoes.Americans love high-heeled shoes. One survey in 2003 reported that 62 percent of American women wore shoes with a 2-inch or greater heel on a regular basis. Those shoes are taking a toll. New research from the University of Alabama at Birmingham shows that high-heeled-shoe-related injuries doubled between 2002 and 2012. The findings were published online May 12 in the Journal of Foot and...