A Postdoctoral position is available in the laboratory of Joanne Murphy-Ullrich, Ph.D., in the Department of Pathology at the Alabama at Birmingham. Our research examines the role of the endoplasmic reticulum stress protein calreticulin in regulating TGF-beta signaling and fibrosis through control of calcium-dependent signaling. This position is funded by a new grant to study the role of calreticulin in TGF-beta signaling in the kidney proximal tubule under diabetic conditions. The applicant will be expected to examine in vitro mechanisms of calreticulin-TGF-beta regulation under high glucose and oxidant conditions and also to perform in vivo studies using several novel mouse models of diabetic nephropathy.
Candidates must have a recent Ph.D. and/or M.D., or equivalent. Priority will be given to qualified candidates with a strong background in cell culture, molecular biology, biochemistry, animal models, and diabetes-related research. The candidate will be expected to write manuscripts and present his/her work at scientific meetings and assist with training of graduate level personnel in the lab. Salary (with benefits) will follow NIH guidelines commensurate with training and experience. Competitive applicants should have a proven track record with publications and the potential for career development. UAB is a highly collegial and interactive environment that has an active Office of Post-doctoral Education which provides mentoring and career guidance in addition to that provided by the mentor.
If interested, please send a letter describing your research experience/interest/future career goals, your CV, and contact information for three references electronically to firstname.lastname@example.org.
Written by Christina Crowe
The National Institutes of Health has awarded the University of Alabama at Birmingham Center for Clinical and Translational Science $33.59 million over four years to continue the center’s programs advancing translational research.
Since its initial funding in 2008 through Alabama’s only Center for Translational Science Award to work toward innovative discoveries for better health, the UAB CCTS has nurtured UAB research, accelerating the process of translating laboratory discoveries into treatments for patients, training a new generation of clinical and translational researchers, and engaging communities in clinical research efforts.
The CCTS will continue to advance its mission to accelerate the delivery of new drugs, methodologies and practices to patients at UAB and throughout a partner network of 11 institutions in the Southeast.
“We are excited by the capacity to continue to enhance our institution’s and our region’s innovative research and medical care,” said Robert Kimberly, M.D., UAB CCTS director. “Through internal and external partnerships, as well as a robust clinical environment and cutting-edge informatics and clinical trial resources, we look forward to working with our patients over the course of their lifespan.”
Congress launched the CTSA program in 2006, which is overseen by the National Center for Advancing Translational Sciences.
The amount of this award, more than double its previous funding awarded in 2008 and one of the largest at UAB, reflects an unmatched enthusiasm for the CCTS and its affiliated programs. It includes funding for 10 annual pre-doctoral training awards, 10 summer training awards, and eight career development awards for senior postdoctoral fellows or faculty-level candidates.
“Our training programs continue to foster a culture of responsible, ethical practice among students, faculty and clinicians conducting human subjects research,” Kimberly said. “The NIH’s support of our expansive partner network, encompassing 11 regional academic and medical institutions throughout Alabama, Louisiana and Mississippi, will allow us to further grow our scope of practices and research resources as we look to tackle health disparities in the Southeast.”
Through One Great Community, the CCTS’ community engagement enterprise, and the Community Health Innovation Awards, the CCTS engages Greater Birmingham-area residents in innovative programs designed by community members to improve their neighborhoods.
“UAB is fully committed to the goals of the CCTS and to its continued development as a hub for clinical and translational research in the Southeast,” said UAB President Ray L. Watts. “This significant renewal speaks to the tremendous work and vision of our CCTS leadership and team, as well as our clinical infrastructure, scientific strengths, informatics expertise, training programs, and biostatistical and research design assistance.
“The CCTS touches researchers in all UAB schools and across the partner network, and we are thrilled that this important work will continue with the confidence and support of the NIH.”
State and regional impact
“The growth of the Center for Clinical and Translational Science at UAB will foster economic development in the state and throughout the region,” said Senator Richard Shelby. “With a history of providing optimal clinical care and innovation in human health, UAB’s receipt of this prestigious award enables the continued development of the workforce that is necessary to meet the needs of future research advancement.”
Alabama Governor Robert Bentley, himself a physician, voiced his appreciation for the CCTS’ initiatives. “The center has been highly effective in providing assistance in the state’s efforts to eliminate the health disparities seen throughout our region,” Bentley said. “Whether across the life course or in underserved groups disproportionately affected by cancer, stroke, heart conditions and other diseases prevalent in our state, the center has been exemplary in reaching out to our citizens.”
UAB Vice President, Research and Economic Development Richard Marchase, Ph.D., says he is particularly pleased that the CCTS is building on UAB’s history of serving populations burdened by health disparities through its partnerships with other state and regional institutions committed to advancing health through translational research. “It is through this culture of commitment and collaboration,” he said, “that we have become a national leader in biomedical research.”