Mentor: Hubert M. Tse, PhD 
Assistant Professor, Department of Microbiology, Comprehensive Diabetes Center, University of Alabama at Birmingham, SHEL 1202, 1825 University Boulevard, Birmingham, AL 35294 htse@uab.edu


A post-doctoral position is immediately available in the laboratory of Hubert Tse in the Department of Microbiology and Comprehensive Diabetes Center.  Our research examines the role of oxidative stress on autoimmune responses in Type 1 diabetes (T1D).  Through the use of novel immunotherapeutics and murine models of T1D, we can determine how reactive oxygen species (ROS) synthesis contributes to innate immune responses and autoreactive T cell effector mechanisms involved in pancreatic b-cell destruction (Padgett et al. NY Annals, 2013).  We seek a motivated, creative, and energetic applicant to contribute to various projects within the lab:

  1. To define the role of ROS synthesis on anti-viral responses to diabetogenic viral triggers (Coxsackievirus) of T1D in both murine models and human translational studies.
  2. To determine the role of oxidative post-translational modifications of putative T1D autoantigens on T cell effector responses.
  3. To define the role and mechanism of thiol signaling on autoreactive CD4 T cell effector responses in T1D.
The laboratory uses immunological methods, molecular biology, cellular biochemistry, redox biology, murine models of T1D, microscopic imaging, and flow cytometry to define novel mechanisms of autoimmune dysregulation.

Candidates must have a recent Ph.D. and/or M.D., or equivalent.  Priority will be given to qualified candidates with a strong background in immunology, molecular biology, biochemistry, flow cytometry, and diabetes-related research.  Experience with mice is also preferred, but not required.  Salary will follow NIH guidelines commensurate with training and experience.  Competitive applicants will have a proven track record in terms of publications and independent funding.

If interested, please send a letter describing your research experience/interest/future career aspirations, your CV, and contact information for three references electronically to:

Hubert M. Tse, PhD 
Assistant Professor, Department of Microbiology, Comprehensive Diabetes Center, University of Alabama at Birmingham, SHEL 1202, 1825 University Boulevard, Birmingham, AL 35294 htse@uab.edu
 

Postdoc Awards and Benefits 

Competitive postdoc awards are available including internships, grant incentives, funds to enhance education and collaboration outside UAB, and teaching opportunities at local universities. There is also a Postdoc Research Day with monetary awards. The OPE strongly encourages UAB research mentors to follow the National Research Service Award stipend level guidelines, and postdoctoral scholars qualify for health, life, and other insurances. They also have the right to participate in the university’s 403(b) program and enjoy vacation, sick leave, maternity/paternity leave, and other benefits.