Research
Bile acid sulfation
Bile acid N-acyl amidation
- Enzymology of bile acid amidation
- Cloning of cDNAs encoding BAL
- Cloning of cDNAs encoding BAT
- Recombinant expression of BAT
- Structural studies with hBAT
Potential projects for graduate students
- Site-directed mutagenesis of rodent liver bile acid CoA: amino acid N-acyltransferase (BAT) - this project involves a combination of molecular biology, enzymology and protein mass spectrometry
- Molecular basis of prevention of eye cataract disease by polyphenol-containing dietary supplements
- Site-specific modification of lens proteins by oxidants - this project involves protein mass spectrometry and other physical chemical techniques