Bile acid sulfation

Bile Acids

Bile acid N-acyl amidation

  • Enzymology of bile acid amidation
  • Cloning of cDNAs encoding BAL
  • Cloning of cDNAs encoding BAT
  • Recombinant expression of BAT
  • Structural studies with hBAT

Potential projects for graduate students

  • Site-directed mutagenesis of rodent liver bile acid CoA: amino acid N-acyltransferase (BAT) - this project involves a combination of molecular biology, enzymology and protein mass spectrometry

  • Molecular basis of prevention of eye cataract disease by polyphenol-containing dietary supplements

  • Site-specific modification of lens proteins by oxidants - this project involves protein mass spectrometry and other physical chemical techniques