Welcome to Targeted Metabolomics and Proteomics Laboratory
The Targeted Metabolomics and Proteomics Laboratory (TMPL) is organized to provide a variety of analytical and technical services using mass spectrometry to UAB investigators. The laboratory currently has five mass spectrometers - two MALDI-TOF instruments, three triple quadrupole instruments and one hybrid quadrupole orthogonal TOF instrument. Two fourier transform-ion cyclotron resonance instruments - supported by NCRR grants were installed during the summer of 2004. (Biomedical FT-ICR Mass Spectrometry Laboratory)
The focus of TMPL is in the use of methods that more carefully target parts of the metabolome and proteome. Discovery mass spectrometry and proteomics identify targets that involve metabolic pathways, signal transduction pathway and protein complexes. TMPL assays allow investigators to carefully and quantitatively explore these specific areas. TMPL also provides methods to dig deeper into the proteome (sample preparation and fractionation) as well as methods to maximize recovery of protein complexes.