Annual Workshop on Metabolomics

The 6th Annual Workshop on Metabolomics will be held July 22-27, 2018 on the campus of the University of Alabama at Birmingham.

The course has been jointly sponsored by the National Institute of General Medical Sciences (NIGMS) as part of the NIH Common Fund Metabolomics Initiative, and the Departments of Chemistry and Pharmacology and Toxicology at UAB.

Details on the workshop can be found on the Metabolomics Workshop web page.

GBSC 724 - The Metabolome and its Importance in Biomedical Research

This course will be held on Mondays, Wednesdays and Fridays from 9-10:30 am and starts on Monday, January 8, 2018.

Why study the metabolome? The metabolome is not just the integration of metabolic pathways generated by the products of our genes, but also all the chemicals that enter our bodies, and/or the models you use in the lab. It provides more information than genomics, transcriptomics and proteomics, and provides a rationale for the regulation of epigenetics.

This course provides understanding of where the chemical complexity of life comes from, how to study it in the context of the experiments you do, how to measure the metabolome, and how to make sense of the results.

Recent publications from TMPL

Impact of genistein on the gut microbiome of humanized mice and its role in breast tumor inhibition. Paul B, Royston KJ, Li Y, Stoll ML, Skibola CF, Wilson LS, Barnes S, Morrow CD, Tollefsbol TO. PLoS One. 2017 Dec 21;12(12):e0189756. [doi: 10.1371/journal.pone.0189756] eCollection 2017. [PMID: 29267377]

Comprehensive profiling of prostaglandins in human ovarian follicular fluid using mass spectrometry. Pier B, Edmonds JW, Wilson L, Arabshahi A, Moore R, Bates GW, Prasain JK, Miller MA. Prostaglandins Other Lipid Mediat. 2017 Nov 9. [doi: 10.1016/j.prostaglandins.2017.11.001] [Epub ahead of print] [PMID: 29129796]

Glutaminolysis Promotes Collagen Translation and Stability via α-ketoglutarate Mediated mTOR Activation and Proline Hydroxylation. Ge J, Cui H, Xie N, Banerjee S, Guo S, Dubey S, Barnes S, Liu G. Am J Respir Cell Mol Biol. 2017 Oct 11. doi: 10.1165/rcmb.2017-0238OC. [Epub ahead of print] [PMID:29019707]

More Publications

About TMPL

The Targeted Metabolomics and Proteomics Laboratory (TMPL) is organized to provide a variety of analytical and technical services using mass spectrometry to UAB investigators. The laboratory has three mass spectrometers, a triple quadrupole instrument (AB Sciex 4000), a quadrupole-linear ion trap instrument (AB Sciex 6500 Qtrap), and quadrupole-TOF (AB Sciex 5600 TripleTOF). The AB Sciex 5600 TripleTOF is particularly powerful for comprehensive and targeted proteomics, lipidomics and metabolomics. The combination of Eksigent microflow 200 LC and 415 nanoLC with the mass spectrometers provides the highest possible sensitivity for sample analysis.

Two fourier transform-ion cyclotron resonance instruments - supported by NCRR grants - are in the Biomedical FT-ICR Mass Spectrometry Laboratory ( Contact Dr. Matt Renfrow about use of these instruments (; 205 996-4681).

A Bruker MALDI TOF-TOF instrument is available in the Comprehensive Cancer Center Core Laboratory of Dr. Jim Mobley (; 205 996-6363).

New sample and data-handling arrangements in TMPL – investigators please note

Figure from J Chromatogr B Analyt
Technol Biomed Life Sci.
[PMID: 20346741]