Clinical Trials

Do you continue to have depression symptoms despite medication? If so, you may be interested to learn more about a clinical research study that is being conducted to evaluate an investigational medication for treatment resistant depression. You may qualify if: you are ages 20-64, have a current diagnosis of Major Depression, experiencing symptoms of depression despite taking antidepressant medication, and are able to consent to participate in the study. All study-related office visits, procedures and study medication will be provided to qualified study participants at no cost. Compensation for time and travel may be provided. 205-975-2911.
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Participants who have had a DaTscan with possible diagnosis of PD ages 19 or older are needed to participate in our research study: Diagnosis of Parkinson Disease using Diffusion Tensor Imaging. This study seeks to develop MRI as a method to improve early diagnosis of Parkinson Disease (PD). This study will conclude in 12-18 months with only two visits within this time period and each participant will receive $30 compensation after their second visit. Paula 205-975-3395.
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Urine leakage does not need to be part of your life. We would like to know if vitamin D can help treat urinary symptoms. If you are female, age 55 or older and experiencing urinary leakage, you may qualify for this study. The UAB Continence Clinic, located at The Kirklin
Clinic, is conducting a research study sponsored by the National Institutes of Health Office on Research of Women¹s Health (ORHW) and the National Institute of Diabetes, Digestive, and Kidney Disease (NIDDK). The study is examining the relationship between urine leakage and treatment with vitamin D. This 12 week study involves 4 clinic visits and two telephone visits.  Study visits are at no cost and participants will be compensated. Interested? Please call 975-3503 and mention the Vitamin D study. It is a blinded randomized controlled trial to see if Vitamin D will improve urge incontinence in women over 55.
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Healthy men and women ages 19-50 who have had genital herpes for at least one year with a minimum of two occurrences are needed for an investigational herpes vaccine study. Compensation is provided. For more information please call 205-996-4099.
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People with type 2 diabetes are needed for a study to help identify the links between diabetes and kidney stone formation. To qualify you must meet the following criteria: ages 19–65; BMI < 32. BMI can be calculated here. Participants will be asked to provide 2 blood samples, four 24-hour urine collections, and consume meals provided by the UAB Clinical Research Unit for 3 days. Compensation up to $250. If you are interested please contact MC at 205-975-8341
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The purpose of the study is to find the best combination drug treatment for diabetes. Have you had Type 2 diabetes for less than 10 years? Is metformin the only diabetes medication you are taking? Are you willing to take a second diabetes drug? If so, you may be able to participate in a clinical research study that is trying to find the best combination drug treatment for type 2 diabetes. Diabetes medications, visits, and lab tests will be provided free of charge. 205-996-4015, 205-996-4020 or 205-975-8217.
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Participate in the development of a new test for vaginal infections. Women ages 19 and older are needed. One visit, one exam.Compensated $30. Please call Joy 205-996-2780
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Healthy African American men and women age 19–45 yrs are needed for a dietary study. We are studying how genes influence the excretion of sodium and calcium in urine. The study involves consuming controlled diets prepared by the Clinical Research Unit, collecting all of your urine for 5 days, and providing 2 blood samples. Compensation $100. Contact M.C. Robertson, (205) 975-8341.
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Women age 19 and older are needed for a research study designed to understand whether the natural body bacteria of black and white women differ and whether stress and weight play a role. Eligible study participants will complete questionnaires, basic body measurements, and provide saliva and stool samples. Two visits total. Compensation is available. For more information, contact Helen at (205) 934-6329 - This email address is being protected from spambots. You need JavaScript enabled to view it. .
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Men and women ages 19-75 abnormal kidney function are needed for a study using a new method to measure kidney function. Subjects will be compensated for participation (up to $800). Call Research Coordinator is Teresa Chacana 205-934-7649 and mention the FAST study.
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You may qualify if you ages 19-45, are African American or European American,  do not have diabetes, exercise less than 2 hours per week, and are willing to travel to UAB for screening and 4 testing visits. Participants will receive their blood sugar level, cholesterol level, bone density, fat mass, and muscle mass. Compensation up to $400 provided for completing all study visits. Please call 934-4386 for more information.

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Participants ages 16-19 and Parents/Guardians of teens 16-18 or 65+ needed for driving study. Must currently drive at least 3 times per week, hold a valid license and be the main driver of a vehicle you own, and own a cell phone with text messaging capability. Minimal risk involved. Requires 2 visits to UAB and installa tion of a camera in your vehicle for 2 weeks. If eligible, compensated up to $150. 205-975-9440.
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We are looking for women age 45-65 to participate in a new vaginal ring study. The study involves five clinic visits. During this time, women will be asked to wear a different vaginal ring each month for three months. Participants will receive physical/GYN exams and HIV/STI testing at no cost and will be compensated up to $450 for their time. For more information, call the AMCRS Team at 205-996-4405.

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Healthy men and women, ages 19-49, who have not had influenza vaccine in the past 6 months are needed for a flu vaccine research study. You will receive 6 intranasal vaccinations during a 14-month period. For more information, call 205-934-6777.

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UAB Department of Psychiatry is currently seeking volunteers who have Bipolar Disorder (also known as Manic-Depression) to take part in a research study looking at an investigational medication. Qualified participants will receive study visits with trained clinicians and study medication at no cost. 

Men and women aged 19 to 75, who are currently on medications for Bipolar Disorder and are still depressed and are physically healthy are qualified to participate.

Interested? Please contact UAB Office of Psychiatric Research at 205-934-2484. 

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UAB Department of Psychiatry is currently seeking volunteers who have Bipolar Disorder (also known as Manic-Depression) to take part in a research study looking at an investigational medication. Qualified participants will receive study visits with trained clinicians and study medication at no cost. 

Men and women aged 19 to 75, who are currently on medications for Bipolar Disorder and are not having problems with mood and are physically healthy are qualified to participate.

Interested? Please contact UAB Office of Psychiatric Research at 205-934-2484.

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You may be eligible to participate in a research study of pain in people with knee arthritis. Eligible candidates must be age 45-85, free from serious medical conditions and be able to come for two testing sessions. If eligible and you enter the study, you may be compensated up to $200. For further information call Adriana at 934-9614.
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UAB's Nutrition Science Department is recruiting 7-to-12 year-old healthy African American boys who may be overweight for a 24-week study aiming to understand how strength training affects bone and muscle development. This study will also investigate whether participating in strength training or not promotes a better ability use nutrients for growth. Not all children will be selected for the strength training group. Groups will be chosen randomly (like the flip of a coin). You and your child will not know which group he is assigned to until after he is enrolled in the study. Compensation is provided and your child will be given the opportunity to be involved in strength training exercises whether chosen to be in the strength training group or not. Information will also be given about your child’s body fat, muscle mass and strength and bone density at the beginning, middle and end of the study. If you are interested in enrolling your child into the study, please contact Anna Carrigan at 205-975-9495 or This email address is being protected from spambots. You need JavaScript enabled to view it. .
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The study will consist of 6-10 testing days, 6 weeks of exercise, 3 or 5 days a week for 20 or 60 minutes each day, and 4 blood draws. Compensated up to $600. For more details and eligibility, call Amy at 205-975-9273.

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August 12, 2013

Driving skills study

Volunteers age 70 and older needed for a study of driving skills. You must be a current driver. You need to own or have access to a computer with high-speed internet. You will complete brief tests to see how well they predict driving skills and safety. You will not be asked to drive. You will receive compensation for participating. Parking is easy and free. You will be offered the opportunity to participate in more research involving training on your own if you have access to a computer with high speed internet. Martha 975-2290.
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Participants will be required to make one visit, answer a short questionnaire about his or her health, a blood draw and a stool sample. Compensation up to $100. 934-2424.
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July 11, 2013

Epilepsy study

The UAB Epilepsy Center is conducting a study comparing different forms of lamotrigine in persons with epilepsy. You may qualify if you are 18 years or older and are taking medication to control seizures. If eligible,you may be compensated up to $1300 for completion of the study. Nancy 934-7244.
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June 18, 2013

High cholesterol?

Men & women age 19 or older with high LDL cholesterol who are currently taking medication to lower cholesterol may qualify for a research study of an investigational cholesterol-lowering medication. Study drug, physical exam, and lab tests at no cost. 934-9502.
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If you have mild to moderate hypertension you may qualify to participate in a national 8-week research study for high blood pressure. Eligible study participants will receive study medication, blood pressure checks, physical exams, lab tests and ECG at no cost. Compensation. 934-9281
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Do you have type 2 diabetes complicated by blood vessel problems such as heart disease, carotid artery disease, stroke, or poor circulation in your legs or feet? If you are over age 50 you may qualify for a research study investigating the effect of a diabetes drug on blood vessel disease. Participants will receive study drug or placebo provided by the study in addition to the care from your usual diabetes care provider. Miriam 975-8217.
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Volunteers age 19-65 with moderate or severe ulcerative colitis needed to study an investigational medicine. All study-related meds, procedures and exams provided at no cost. To learn more, call 1-877-UAB-4-IBD.
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The UAB Center for Nursing Research has developed a Web site that addresses the pain experienced by patients with CF. Visit the site for information regarding CF and also take part in a new on-line research study. Patrick This email address is being protected from spambots. You need JavaScript enabled to view it. or 934-7597.
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The UAB Lung Health Center is doing research to find better ways of diagnosing and treating COPD. Normal, healthy people age 40-75 needed. 934-5555 to see if you qualify for a current study.
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June 18, 2013

Depression studies

Feeling sad, down, hopeless? Feeling guilty, tense or irritable? Wishing you were dead?  Experiencing disturbed concentration, appetite, or sleep? If you are age 19-65, you may be eligible to participate in a research study on an investigational medication for depression. Compensated. Office of Psychiatric Research 934-9189.
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If you currently take no pills or one, two or three pills for diabetes, you may be eligible for a research study of a new diabetes medication taken one time a week. The study drug will be added to your current treatment plan. Compensation up to $700. 975-8217.
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June 18, 2013

CROSSROADS study

Men and women ages 65 and older needed to participate in a study that examines how lifestyle changes affect body fat, risk factors for disease and quality of life. This study requires a 1-year commitment. You may qualify if you are in generally good health and you are on medication for high blood pressure, high cholesterol, or diabetes. Compensated up to $225. CROSSROADS Study 996-5295.
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If so, you may qualify for a research study. To be considered you must be at least 50 years of age, have high blood pressure with a systolic (upper) number of at least 130 and have no history of diabetes or stroke. If you qualify for the study, receive the following at no cost: FDA approved blood pressure medication, regular medical testing, memory testing, EKG’s (electrocardiograms), and blood pressure management. Compensation. Call the SPRINT office of Dr. Thornley-Brown in the Department of Nephrology, 975-4482.
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Men & women age 65 and older with high blood pressure needed for a study to see whether adding a medication to current blood pressure treatment lowers the risk of cardiovascular events. Participants can have a history of heart disease, stroke or diabetes, or have risk factors for heart disease Compensation. 975-7902 or 1-866-965-7903.
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A 24-month research study is being conducted by the UAB School of Dentistry to determine the effectiveness of a commercially available tooth colored dental filling materials bonded on the sides of teeth with three adhesives. Enrollment in the study requires that the subject be available for the 24-month study period. Screening appointments now are available and subjects needing fillings on the sides of their teeth are likely candidates. The fillings are free and a monetary incentive is paid at each recall visit. To determine if you are eligible for this study, call LaTara 996-5747.
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June 18, 2013

Sleep study

Does your partner complain that you have been kicking, screaming, punching, grabbing or even jumping out of bed at night while you are otherwise asleep or have you been diagnosed with REM Behavior Disorder by a sleep medicine specialist or a physician? We are recruiting subjects ages of 25-85 for a study looking at the differences in the brains of healthy individuals compared to those who have REM behavior Disorder. The study will involve two initial visits. Following this, there will be a phone interview every 6 months, then a follow-up visit at two years, followed by phone interviews every 6 months. Involvement in this study could last for up to five years. There will be a $30 compensation after the 2nd and 3rd visit. Dr. Frank Skidmore 975-3395.
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We are studying differences between the brains of healthy individuals and people with Parkinson's Disease, or those at risk for developing Parkinson's Disease. The study will involve two visits, including a MRI of the brain during the second visit. You will be compensated $30 after the 2nd visit after your MRI scan. Dr. Frank Skidmore 975-3395.
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We are studying differences between the brains of healthy individuals and people with Parkinson's disease, or those at risk for developing the disease. The study will involve two visits, including a MRI of the brain during the second visit. Compensated $30 after your MRI scan. Dr. Frank Skidmore 975-3395.
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Do you have a history of heart disease OR diabetes and/or other cardiovascular risk factors?  If so, you may be eligible for the REDUCE-IT trial. REDUCE-IT is a research study testing an investigational drug. Eight study visits over 5 years. Compensated up to $500. Call 205-975-7238, option 2.
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UAB researchers want to interview and track men and women who have recently quit heavy or problem drinking without treatment. If you are such a person, we believe you could provide valuable information that may improve programs to help others quit. This study is not a treatment program. Confidentiality will be strictly maintained. We come to you. Interviewed participants will be reimbursed for their time and effort. 934-6082 or 800-815-6200 or www.HealthyDecisions.uab.edu.
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Are you ages 19-64 and are currently feeling down, sad, or hopeless? Feeling guilty, tense, or irritable? Are you experiencing disturbed sleep, eating, or concentration? Are you in good physical health? Have you tried at least 1 antidepressant medications in the past? If so, you may be eligible to participate in a research study on an investigational treatment for depression involving low field magnetic stimulation. Compensation. 934-2484.
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You may qualify to participate in an international 18-36 month research study to evaluate the safety and tolerability of an investigational drug for patients with peripheral artery disease (PAD). Are you at least 50 years old? Do your legs hurt? Eligible study participants will receive study medications, blood pressure checks, physical exams, laboratory tests and ECGs at no cost. 934-9281.
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The UAB School of Dentistry, Department of Periodontology, is recruiting participants for a new research study that will test the safety and effectiveness of a new synthetic bone grafting material when used to treat oral bone loss resulting from Periodontal (gum) Disease. Eligible candidates must be age 25 or older and have a particular type of Periodontal Disease diagnosis. The study will require multiple visits to the Periodontal Research Clinic over a period of approximately 6-months. Women who are pregnant, nursing or planning a pregnancy will be excluded. Other medical conditions and medications may also prevent enrollment. 205 934-1503.
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To join the study you must: be age 50 or older; have type 2 diabetes and certain kinds of heart disease or stroke; and be able to attend 17 clinic visits and answer 9 phone contacts over a three-year trial period. The study provides an investigational medication that is taken once weekly. If eligible, you may be compensated up to $640 for completing all study visits. 205-934-2294.
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You may qualify for a new research study at the Birmingham VA Medical Center offering behavioral therapies that can help. You must be: a veteran, age 50 or over, diagnosed with Parkinson's disease, accidentally leaking urine at least 4 times a week, willing to attend clinic visits and follow instructions at home. This study does not involve any medications. 934-3259 and ask for the BETTUR study.
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Are you ages 19-65? You may qualify for a study that is looking at a once monthly treatment for bipolar symptoms. Sherer 996-5987.
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If you are age 19-65, feeling sad, down, hopeless; feeling guilty, tense, or irritable; in good physical health; experiencing disturbed concentration, appetite or sleep and have tried at least 1 antidepressant medication and still experiencing depression? You may be eligible to participate in a research study on an investigational treatment for depression involving Low Field Magnetic Stimulation (LFMS). For more information and to determine eligibility, call 934-2484. Compensation provided.
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Call The UAB Lung Health Center at 934-5555. You may qualify for a study.
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If you urinate at least 9 times in 24 hours, wake up at night to urinate, or have urine accidents, you may be eligible for the COBALT study. Medications and compensation. 934-3259.
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June 18, 2013

BRAVO study

Do you want to earn up to $360 and be part of a national study to identify new ways to test for and prevent vaginal health problems? Join the BRAVO! Study today! Women ages 15-25. Joy 996-2780.
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You may be eligible to participate in a dissertation study to help determine if exposure to magazine advertisements is associated with body mass index. The study involves a 1-time web-based survey that takes approximately 15 minutes. If interested, visit www.surveymonkey.com/s/MAGS. Candice Griffin 223-8941.
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The “ROSETTA” Study may be right for you! UAB in conjunction with the Pelvic Floor Disorders Network (PFDN), sponsored by the National Institutes of Health, is conducting a research study aimed at the treatment of women with urinary urge incontinence using Botox A® and InterStim Therapy®. If you are experiencing a sudden strong desire to go to the bathroom that causes leakage of urine and: Are female age 21 or older; experience leakage three or more times per day; have tried at least two medications for urine leakage; may have tried other treatments such as pelvic muscle exercises; have not had Botox A® for treatment of urine leakage; have not had InterStim therapy® for urine leakage then you may be eligible to participate in the ROSETTA Study. Compensation provided. 934-5498 or Toll free 1-877-496-4673, option #6.
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Nutrition Sciences is looking for breast cancer survivors who are not regular exercisers to participate in a research project. The study evaluates the BEAT Cancer program, designed to help breast cancer survivors start and maintain an exercise program. This study includes supervised, individual exercise sessions with exercise specialists. The study is funded by the National Cancer Institute. Participants must be ages 19-70 with a history of DCIS, Stage I, II or IIIA breast cancer. For more information, call (205) 975-1247 or email  This email address is being protected from spambots. You need JavaScript enabled to view it. . All information is confidential and participation is free.
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Caucasian or African-American woman age 21-40 needed to participate in an exercise intensity study that is being conducted by the UAB Departments of Human Studies and Nutrition Sciences. This is a 16-week study that requires (4) overnight stays at UAB (over a 16 week period). If you are diabetic, smoke or are more than moderately overweight, you will not qualify. Participants will enroll in an exercise program bike riding and walking). Improve your fitness level and receive information that includes your daily caloric expenditure, physical fitness level, bone density and body fat composition. May be compensated. Brandon, the Exercise Intensity Study, 975-3806.
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We are looking for adolescents with type 2 diabetes and an A1C between 6.5 and 10.5% to assess the safety and efficacy of a non-insulin, injectable anti-diabetic investigational medication for type 2 diabetics. Subjects taking insulin will not qualify.  If your child qualifies, they will receive the following at no cost to you: study related physical exams and laboratory tests, diabetes education and coaching, study medication and supplies, and compensation for your time. Victoria Gunter, 996-7648, This email address is being protected from spambots. You need JavaScript enabled to view it. .
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Healthy, overweight 7-11 year females needed to participant in an observational study to investigate health effects of prolonged sitting. We are recruiting African or European American, prepubertal females for a 16-week study. Involves four 2-day visits and compensation. Annie, 975-3494.
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A study is recruiting overweight African-American and European American girls ages 7-11 to investigate the effects of diet on weight-loss and body composition. This 25-week study involves 7 clinic visits, 7 education sessions, and compensation. The PRIMO study, Annie 975-3494
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You will view a set of images in the MRI scanner and respond to simple questions by pushing a button. Study will take 2-3 hours total (1 hour in scanner) and can be completed in two separate sessions or in a single day. Compensated $50. Dr. Rajesh Kana 996-9368.
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research match

By taking part in a clinical trial at UAB, you can help generate knowledge that will change the world. Volunteers play a vital role in UAB's internationally renowned research enterprise.

You can also join ResearchMatch, a multi-institution project that pairs volunteers with researchers seeking study participants.

Trials currently available at UAB are listed above; click the tags to refine the list or search for a specific trial. To submit a trial for inclusion in this list, click here.