The National Institute of Diabetes and Digestive and Kidney Diseases has renewed a grant shared by UAB and the University of California, San Diego, that will extend and expand research into acute kidney failure, or acute kidney injury, which kills 70 to 80 percent of patients in intensive care units who develop the disease.
The rate of acute kidney injury has increased in recent years as more patients are older, diabetic, obese and hypertensive, and mortality rates from the disease have not improved in the past 40 years.
“It’s a disease that’s getting worse; it’s not getting better,” said Anupam Agarwal, M.D., a nephrologist in the School of Medicine and interim senior vice president for Medicine and dean of the School of Medicine.
Since 2008, Agarwal has lead the O’Brien Center for Acute Kidney Injury Research, one of seven federally funded centers in the country aimed at making state-of-the art technologies and resources readily accessible to researchers pursuing studies in relevant areas related to kidney disease. The center serves as a national core resource to identify and fund promising research and to provide important scientific services to the funded investigators. The five-year, $5.64 million renewal (NIH P30 DK079337) will expand efforts, including work to find genetic determinants for early detection and expand an international registry.
In the center’s first five years, “we have been able to bring together world renowned scientists and brought to bear their expertise on this disease,” said Paul Sanders, M.D., associate director of the center and a professor of medicine in the Division of Nephrology. Their efforts resulted in more than 640 collaborative interactions among researchers and more than 175 peer-reviewed scientific publications. A total of $570,000 was awarded to 15 pilot projects to young investigators, which in turn garnered an additional $7 million in new extramural funding, a 12-to-1 return on investment.
Read more about the grant and the Center.
Call for proposals: Explore research for palliative careThe Palliative Research Enhancement Project invites research proposals for innovative translational and/or clinical research projects that use palliative medicine.UAB awarded $9.7 million to find treatments for deadly lung diseaseGrant will allow UAB researchers to study novel therapies for pulmonary fibrosis, a deadly lung disease with no approved treatments.UAB vision scientist awarded $1.81 million grant for photoreceptor researchLawrence Sincich, Ph.D., received a $1.81 million NIH National Eye Institute award for work that will lead to better understanding of color perception in the brain.Grant renewal extends, expands national research of kidney failureWorld-renowned scientists search for ways to prevent acute kidney failure, improve management of the disease.National women’s HIV study comes to UABStudy examines how HIV affects the health of women.UAB, BBA partner to win prestigious $600,000 NSF Partnership for Innovation grantThe NSF will support a UAB/BBA collaboration through a $600,000 award — the first Partnership for Innovation grant ever given in Alabama.UAB DRC awarded grant, recruiting for national studyUAB investigators are studying the long-term benefits and risks of four widely used diabetes drugs in combination with metformin, the most common first-line medication for treating type 2 diabetes. Recruitment of volunteers for the project, called the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study, begins in June.UAB and School of Dentistry ranked first nationally in NIDCR fundingThe UAB School of Dentistry received more funding from the National Institutes of Health in 2012 than any other school of dentistry in the nation.UAB glaucoma researchers to study biomechanics of eyeThe primary investigators are examining whether age- and race-related differences in the biomechanics of the optic nerve head may contribute to this risk.UAB Diabetes Research Center receives 5 year grant exceeding $5 millionThe Diabetes Research Center (DRC) focuses on developing new methods to treat, prevent and ultimately cure diabetes and its complications.