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Douglas R. Moellering, Ph.D.

Primary Faculty

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Assistant Professor

Address:
1670 University Blvd.
Volker Hall G004
Birmingham AL 35294-00019 USA

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Phone: (205) 996-2660

Fax: (205) 996-5895

Other information

Other information:

Dr. Moellering is an instructor of nutrition sciences, a scientist in the Center for Cardiovascular Biology, a scientist in the UAB Comprehensive Diabetes Center (UCDC), and manager of the Diabetes Research Center's Redox Biology Core (BARB) at UAB. Dr. Moellering developed and manages the Redox Core serving multiple investigators in measuring functional mitochondrial physiology, bioenergentics, enzyme activity, markers of oxidative stress, and reactive oxygen species formation.
Research Interest
Eighty percent of the air we breathe and most of the food that is consumed and absorbed are metabolized within mitochondria to produce 90 percent of the energy in the form of ATP necessary for use in all cellular processes, including exercise, growth, and reproduction. Evidence has been accumulating that many diseases involve mitochondrial dysfunction with concomitant increased reactive oxygen and/or nitrogen species formation. Some of these diseases include insulin resistance, type 2 diabetes mellitus (T2DM), Parkinson's disease, Alzheimer's disease, cardiovascular disease, atherosclerosis, cancer, obesity, and Harman’s free-radical theory of aging (although aging is not a disease). These reactive products are called free radicals since they contain one or more unpaired electrons. Free radical-mediated alterations in energy production, tissue injury, and human disease are pervasive, and still poorly understood. Our research interests involve mitochondrial physiology, bioenergetics, and free radical-mediated tissue injury and disease pathologies. Currently our research is focused on mitochondrial free-radical production contributing to altered bioenergetics, the development of obesity, insulin resistance and T2DM, increased cardiovascular disease susceptibility, and aging.
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