A randomized, 30-week, active-controlled, open label, 2 treatment-arm, parallel-group, multicenter study comparing the efficacy and safety of the insulin glargine/lixisenatide fixed ratio combination to insulin glargine with or without metformin in patients with T2DM
The purpose of this study is to evaluate the possible risks and the effectiveness of the insulin glargine/lixisenatide fixed ratio combination self-injected once daily as compared to insulin glargine self-injected once daily in the treatment of patients with type 2 diabetes.  To be in this study, you will have to stop all other antidiabetic medications except for metformin.  The study is being conducted at UAB by the Department of Nutrition Sciences .  For more information, and to see if you might be eligible to join, please contact (205)996-4015 or (205)996-4020.

GRADE Study (The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study).

The purpose of the study is to find the best combination drug treatment for diabetes. Have you had Type 2 Diabetes less than 10 years? Is metformin the only Diabetes medication you are taking? Are you willing to take a second Diabetes drug? If so, you may be able to participate in a clinical research study that is trying to find the best combination drug treatment for type 2 Diabetes. Diabetes medications, visits, and lab tests will be provided free of charge.

Please call the following numbers for more information (205)996-4015, (205)996-4020 or (205)975-8217.


The purpose of this study is to find out why some individuals are insulin resistant, while other individuals are insulin sensitive. Insulin moves glucose (sugar) from the bloodstream into the muscle, where it is metabolized (used by the body). In many individuals, this process is impaired; the body tissue resistance to the effects of insulin increases the risk of developing diabetes, hypertension (high blood pressure), heart disease, and stroke (associated with hardening of the arteries). The investigator hopes to better understand the actual biochemical cause of this insulin resistance, since this knowledge could be used to develop improved methods of treatment or prevention. You will receive laboratory testing, metabolic testing & physical exam, all at no charge to you. We are recruiting both healthy volunteers ages 21-59 and those with Type 2 Diabetes. To inquire, please contact Sandra at 205-996-4020 or Dana at 205-996-4015.

The purpose of this study is to see the effects of different macronutrient profiles on weightloss in overweight girls.  We seek to evaluate the effects of different weightloss diets on bone and fat mass as well as metabolism. Overweight girls ages seven to eleven years are invited to participate.  All food will be provided for sixteen weeks.  This study requires consumption of only included foods over the duration of the study.  In addition, for assessment of metabolic parameters, meal tests with blood draws are necessary. Compensation. To inquire, please contact Krista or Annie at 205-975-4316.

The purpose of this study is to examine the contributions of genetic and environmental factors on racial differences in the risk for diabetes.

EXSCEL STUDY: A Randomized, Placebo Controlled Trial to Evaluate Cardiovascular Outcomes after the Treatment with Exenatide Once Weekly in Patients with Type 2 Diabetes Mellitus.
The primary study objective is to compare the impact of including Exenatide Once Weekly as part of usual care versus usual care without Exenatide Once Weekly on major cardiovascular outcomes. Phase 3b/4 eligibility: Adults with type 2 diabetes with a hemoglobin A1c of 7 or greater but equal to or less than 10 receiving a stable (at least 3 month) dose of 0-3 medications for diabetes who have a history of cardiovascular disease.