The aim of this study is to have culturally adaptive, long-distance communication and learning applications for clinical research coordinators that can enhance the productivity and quality of active U.S.-international research and research-training collaborations. For this grant, four courses will be developed and offered during a 30-week period each year for two years to a total 150 study coordinators from international sites.  A fifth, optional course also will be developed and offered for in-depth study or development of special projects with mentoring from course faculty.