The UAB ITREOH, a collaborative research training effort with the Aga Khan University (AKU) of Karachi, Pakistan, seeks to expand its training and research collaboration in South Asia. South Asian countries, including Pakistan, are transitioning from an agrarian to an industrialized economy with a myriad of new environmental and occupational health (EOH) concerns. There are no university-based training programs in this region specifically designed to train the necessary professionals to take on these challenges. The UAB-AKU partnership has resulted in the establishment of a core group of researchers/trainers at AKU who have developed skills in environmental epidemiology, who provide input at the nation level, and have implemented an EOH certificate program at AKU. Our new proposal includes two other principal partner institutions that were identified during our regional training efforts, the Manipal Academy of Higher Education (MAHE) in India and the Ministry of Health (MOH) in Sri Lanka. The proposed training program will focus on prevention and intervention research as applied to the mitigation of environmental and occupational hazards. A major highlight of the collaboration will be the development of an EOH graduate degree program at AKU.