Antibody Catalog


Antibody Catalog (pdf format)

Antibodies available for licensing

General information:

The antibodies contained in this list represent those that have been formally disclosed to the UAB Research Foundation by UAB researchers. This list is not a complete list of antibodies that have been produced at UAB. Many more antibodies produced at UAB have been described in the scientific literature and are likely to be available for licensing upon request.

Please note that due to factors beyond our control, hybridomas and/or antibodies listed in this document may no longer be available. The availability of the material will be verified prior to the execution of any license agreement.

Any license for either hybridomas or antibodies will be non-exclusive.

For more information or to request a license please contact

Dugald Hall, PhD
Licensing Associate
UAB Research Foundation
Email: dhall@uab.edu
Phone: 205-996-7578


UAB Reference

Title and Description

Keywords

U1981-0003 The Hybridoma Human Natural Killer-1 (Leu-7) Human natural killer-1; HNK-1
  This clone, HNK-1, is described in: Abo T, Balch CM, “A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1).” Journal of Immunology, 1981; 127(3):1024-9.
U1983-0001 The Hybridoma MMA (Anti-Leu-M1) Lex blood group antigen; lacto-N-fucopentaonse III; CD15
  The monoclonal antibodies produced by this hybridoma (MMA) react with the Lex blood group antigen, lacto-N-fucopentaonse III or the CD15 antigen. This antibody is described in: Hanjan SN, Kearney JF, Cooper MD, “A monoclonal antibody (MMA) that identifies a differentiation antigen on human myelomonocytic cells.” Clinical Immunology and Immunopathology, 1982; 23(2):172-88.
U1983-0002 The Hybridoma TB-28 (anti-kappa) Human Ig-kappa

  Hybridoma TB-28 produces the monoclonal antibody directed against human Ig-kappa (anti-kappa). This Hybridoma Cell Line is described in Kiyotaki M, Cooper MD, Bertoli LF, Kearney JF, Kubagawa H. "Monoclonal anti-Id antibodies react with varying proportions of human B lineage cells." Journal of Immunology 138:4150-4158 (1987) and Nakamura T, Kubagawa H, Cooper MD. "Heterogeneity of immunoglobulin-associated molecules on human B cells identified by monoclonal antibodies." Proceedings of the National Academy of the Sciences U S A. 89:8522-8526. (1992).
U1983-0003 The Hybridoma D-12 (anti-Leu-15) Leu-15; T-cell response
  Hybridoma D-12 produces the anti-Leu-15 monoclonal antibody. This hybridoma cell line is described in: Landay A, Gartland GL, and Clement LT. “Characterization of a phenotypically distinct subpopulation of Leu-2 + cells that suppresses T cell proliferative responses." Journal of Immunology 131:2757-2761 (1983) and Clement LT, Grossi CE, Gartland GL. "Morphologic and phenotypic features of the subpopulation of Leu-2+ cells that suppresses B cell differentiation." Journal of Immunology 133:2461-2468 (1984)
U1984-0004 The Hybridoma HB-5 (anti-CR-2) C3d receptor; C3dR; complement receptor 2; CR2
  HB-5 monoclonal antibody recognizes C3d receptors (C3dR; also know as complement receptor 2; CR2) on B lymphocytes. This hybridoma is described in: Tedder TF, Clement LT, Cooper MD, “Expression of C3d receptors during human B cell differentiation: immunofluorescence analysis with the HB-5 monoclonal antibody.” Journal of Immunology, 1984; 133(2):678-83.
U1985-0003 The Hybridoma HB-7 (Anti-Leu-17) Human CD38; transmembrane protein
  The HB7 monoclonal antibody reacts with the human CD38 molecule, an approximately 45 kDa type II transmembrane protein. This antibody is described in: Tedder TF, Clement LT, Cooper MD, “Discontinuous expression of a membrane antigen (HB-7) during B lymphocyte differentiation.” Tissue Antigens, 1984; 24(3):140-9.
U1987-0007 A B Cell Hybridoma, 2D2, That Produces the Murine 2D2 Antibody Murine 2D2; T-cell
  This B cell hybridoma cell line produces the 2D2 monoclonal antibody. This monoclonal antibody identifies a phenotypically distinct subpopulation of cells within the Leu-2+ suppressor/cytotoxic T cell subset that suppress T-cell proliferative responses. The hybridoma and monoclonal antibody is described in Landay A, Gartland GL, and Clement LT. “Characterization of a phenotypically distinct subpopulation of Leu-2 + cells that suppresses T cell proliferative responses." Journal of Immunology 131:2757-2761 (1983)
U1988-0001 Hybridoma Clone Anti-Tau-2 Tau
  The antibodies produce by this hybridoma stain the human neurofibrillary tangles, neuropil threads and neuritic plaques associated with Alzheimer's disease. The antibody also stains astrocytes and ribosomes. Tau-2 may be used with formalin-fixed paraffin-embedded sections of human brain tissue. This antibody is described in: Papasozomenos SC, Binder LI, “Phosphorylation determines two distinct species of Tau in the central nervous system.” Cell Motility and the Cytoskeleton, 1987; 8(3):210-26.
U1989-0002 MAP2 Antibody Microtuble associated protein 2; MAP2
  Microtubule associated protein 2 (MAP2) exists in two high molecular weight forms (2a & 2b) and a low molecular weight form. This antibody is highly specific to MAP2a,b and shows no cross-reaction with MAP1, MAP5, tubulin, or tau. Ab-2 reacts with dendrites and cell bodies of neurons but not with the neuronal processes. It does not react with the low molecular weight (70kDa) form (2c) of MAP2. This antibody is described in: Binder LI, Frankfurter A, Rebhun LI, “Differential localization of MAP-2 and tau in mammalian neurons in situ.” Annals of the New York Academy of Sciences, 1986; 466:145-66.
U1989-0022 Monoclonal Antibody Directed Against Vasopressin Vasopressin; hormone
  This is a monoclonal antibody directed against the hormone vasopressin. This offers benefits over polyclonal antibodies against this hormone as it provides a continuous supply of an identical antibody.
U1989-0032 Cell Lines for Monoclonal Antibodies to Feline CD3/CD5 (clone f43), CD4 (clone 3-4f4), and CD8 (clone fCD8) Feline CD3/CD5; CD4; CD8
  These antibodies are described in the following papers:

Dean GA, Quackenbush SL, Ackley CD, Cooper MD, Hoover EA, “Flow cytometric analysis of T-lymphocyte subsets in cats.” Veterinary Immunology and Immunopathology 1991; 28(3-4):327-35.

Ackley CD, Hoover EA, Cooper MD, “Identification of a CD4 homologue in the cat.” Tissue Antigens, 1990; 35(2):92-8.
U1990-0002 Mouse Monoclonal Antibodies to MAP1B and Tau Microtubule associated protein; MAP1B; Tau
  Antibody clones 3G5 and 6D4 are directed against nonphosphorylated and phosphorylated epitopes of MAP1B, respectively. These antibodies are described in: Edelmann W, Zervas M, Costello P, Roback L, Fischer I, Hammarback JA, Cowan N, Davies P, Wainer B, Kucherlapati R, “Neuronal abnormalities in microtubule-associated protein 1B mutant mice.” Proceedings of the National Academy of Sciences of the United States of America, 1996; 93(3):1270-5.
U1990-0040 Monoclonal Antibody CE1 Murine CNS myelin/oligodendricytes
  Monoclonal antibody clone CE1 is a mouse anti-CNS myelin/oligodendrocytes that recognizes myelin and oligodendrocytes in the CNS. This antibody is described in: Dyer CA, Hickey WF, Geisert EE Jr., “Myelin/oligodendrocyte-specific protein: a novel surface membrane protein that associates with microtubules.” Journal of Neuroscience Research, 1991; 28(4):607-13.
U1991-0008 Monoclonal Antibody Containing the FC Receptor of IgA Human Fcα receptor; FcαR
  These antibodies bind to the human Fcα receptor (FcαR) on immuno-competent cells. These antibodies are described in: Monteiro RC, Cooper MD, Kubagawa H, “Molecular heterogeneity of Fc alpha receptors detected by receptor-specific monoclonal antibodies.” Journal of Immunology 1992; 148(6):1764-70.
U1991-0018 Hybridoma DA4-4 (HB57) Human IgM heavy chain
  Anti-Human IgM (µ chain specific) monoclonal antibody DA4-4 (HB57) reacts with human IgM through an epitope on the heavy chain. This antibody is non-reactive with IgG, IgA or light chains. Clone HB57 produces an antibody with one of the highest affinities available (Ka = 5.34 x 108 M-1). The following papers describe this antibody:

Maruyama S, Kubagawa H, Cooper MD, “Activation of human B cells and inhibition of their terminal differentiation by monoclonal anti-mu antibodies.” Journal of Immunology 1985; 135(1):192-9.

Rudich SM, Winchester R, Mongini PK, “Human B cell activation. Evidence for diverse signals provided by various monoclonal anti-IgM antibodies.” Journal of Experimental Medicine, 1985; 162(4):1236-55.
U1991-0023 Monoclonal Antibodies Against Human β-Glucuronidase Human β-glucuronidase
  These hybridoma cell lines produced from BALB/c mice produce monoclonal antibodies against human β-glucuronidase. The monoclonal antibodies produced by these hybridomas detect B-glucuronidase from a number of sources (liver, kidney, spleen and urine). Two of the monoclonal antibodies (7B6 and 6D2) produced by these hybridoma cell lines have been used to develop an ELISA for the quantification of human β-glucuronidase. This is described in Ho KJ. "Development and optimization of an enzyme-linked immunosorbent assay employing two murine monoclonal antibodies for absolute quantitation of human beta-glucuronidase." Biotechnology and Applied Biochemistry 16:1-10 (1992).
U1991-0034 Rat Monoclonal Anti-Mouse EHS Laminin Antibodies Englebreth-Holm-Swarm tumor laminin; EHS laminin
  These monoclonal antibodies recognize mouse Englebreth-Holm-Swarm (EHS) tumor laminin. This collection of antibodies are described in: Abrahamson DR, Irwin MH, St John PL, Perry EW, Accavitti MA, Heck LW, Couchman JR, “Selective immunoreactivities of kidney basement membranes to monoclonal antibodies against laminin: localization of the end of the long arm and the short arms to discrete microdomains.” Journal of Cell Biology 1989; 109(6 Pt 2):3477-91.
U1991-0036 Monoclonal Antibody for Antigen of Streptococcus pneumonia Streptococcus pneumoniae type 3 capsular polysaccharide
  This monoclonal antibody is a human IgM, lambda specific for type 3 capsular polysaccharide antigen of Streptococcus pneumoniae. This antibody is described in: Shaw DR, Kirkham P, Schroeder HW Jr, Roben P, Silverman GJ, “Structure-function studies of human monoclonal antibodies to pneumococcus type 3 polysaccharide.” Annals of the New York Academy of Sciences 1995; 764:370-3.
U1991-0042 Cell-Line Producing Monoclonal Antibodies to BAC-1 Antigens BAC-1 antigen; B-cells
  The antibody Bac-1 (clone 9.4), detects an antigen expressed early in the course of B cell activation. This antibody is described in: Suzuki T, Sanders SK, Butler JL, Gartland GL, Komiyama K, Cooper MD, “Identification of an early activation antigen (Bac-1) on human B cells.” Journal of Immunology 1986; 137(4):1208-13.
U1991-0052 Monoclonal Antibody Against Glial Cell Adhesion Molecules Glial cell adhesion molecule; G-CAM
  The monoclonal antibody AMP1 recognizes a cell adhesion molecule present on astrocytes. This protein has been termed ‘glial cell adhesion molecule’ (G-CAM). This antibody is described in: Geisert EE Jr, Murphy TP, Irwin MH, Larjava H, “A novel cell adhesion molecule, G-CAM, found on cultured rat glia.” Neuroscience Letters 1991; 133(2):262-6.
U1991-0058 Establishment of an Anti-IL-6 Monoclonal Antibody IL-6; plasma cell growth factor; PCT-GF
  Hybridoma 5B12.1 produces a monoclonal antibody against IL-6. This monoclonal antibody is not species specific. It reacts with plasma cell growth factor (PCT-GF) derived from rat and mouse, recombinant mouse and recombinant human IL-6. This is described further in Sawamura M, Everson MP, Shrestha K, Ghanta VK, Miller DM, and Hiramoto RN. "Characterization of 5B12.1, a monoclonal antibody specific for IL-6." Growth Factors, 3:181-190 (1990).
U1991-0059 HUAB14-3 human IgM monoclonal antibody to Streptococcus pneumoniae type 3 capsular polysaccharide. Streptococcus pneumoniae type 3 capsular polysaccharide
  HUAB14-3 human IgM monoclonal antibody to Streptococcus pneumoniae type 3 capsular polysaccharide was derived by EBV immortalization of human spleen cells from a patient immunized with the 14-valent polysaccharide vaccine prior to therapeutic splenectomy. This monoclonal antibody is described in Shaw DR, Kirkham P, Schroeder HW Jr, Roben P, and Silverman GJ. "Structure-function studies of human monoclonal antibodies to pneumococcus type 3 polysaccharide." Annals of the New York Academy of Sciences, 764:370-373 (1995).
U1992-0002 Antibodies Against the Cystic Fibrosis Transmembrane Regulator Cystic fibrosis transmembrane regulator; CFTR
  Rabbit polyclonal antibodies raised against HPLC purified synthetic peptides corresponding to two discrete regions of the cystic fibrosis transmembrane regulator protein (CFTR). These antibodies precipitate a polypeptide at identical molecular masses, consistent with the predicted size of CFTR (180,000) from solubilized T-84 cell lysates. These antibodies also specifically recognize CFTR-related polypeptides in heterologous systems optimized for the expression of the CFTR protein. These antibodies are described in Fuller CM, Howard MB, Bedwell DM, Frizzell RA, and Benos DJ. "Antibodies against the cystic fibrosis transmembrane regulator." The American Journal of Physiology, 262:C396-404 (1992).
U1992-0004 Antibodies Which Recognize Different Sites on Type II Collagen Type II collagen; avian; human; mice
  These monoclonal antibodies recognize specific sites on type II collagen from chicken, humans and mice. These antibodies are described in: Mayne R, Mayne PM, Ren Z, Accavitti MA, Gurusiddappa S, Scott PG, “Monoclonal antibody to the aminotelopeptide of type II collagen: loss of the epitope after stromelysin digestion.” Connective Tissue Research 1994; 31(1):11-21.
U1992-0005 Anti-fibrillin Fibrillin; bovine; human
  Monoclonal antibodies to bovine fibrillin which cross react with the human molecule. These antibodies also exhibit discrete staining of normal fibroblasts in culture and of extracellular (elastin) fibrils in a variety of tissues. These antibodies are described in: Wright DW, McDaniels CN, Swasdison S, Accavitti MA, Mayne PM, Mayne R, “Immunization with undenatured bovine zonular fibrils results in monoclonal antibodies to fibrillin.” Matrix Biology 1994; 14(1):41-9.
U1992-0013 Monoclonal Antibody 40.15, Specific for Rhesus Monkey IgA Rhesus monkey IgA
  Monoclonal antibody 40.15 binds specifically to both serum and secretory (colostral) rhesus IgA in Western blots. This antibody does not bind to IgG or IgM when tested by enzyme-linked immunosorbent assay. This antibody is described in Ward DC, Jackson S, Eldridge JH, Radl J, Michalek SM. "Generation of monoclonal antibodies to Macaca mulatta (rhesus) IgA." Journal of Medical Primatology 24:74-80 (1995).
U1992-0014 Human Monoclonal Antibody 4B5 (An Ant-Id that mimics GD2 Antigen) GD2 antigen mimic; murine 14G2a idiotype
  This is a human monoclonal antibody which is directed against the idiotype of murine 14G2a. This antibody also mimics the GD2 antigen which is expressed on melanoma, neuroblastoma and small cell carcinoma of the lung. This antibody is described in: Saleh MN, Stapleton JD, Khazaeli MB, LoBuglio AF, “Generation of a human anti-idiotypic antibody that mimics the GD2 antigen.” Journal of Immunology 1993; 151(6):3390-8.
U1992-0033 CMV monoclonal antibody Human cytomegalovirus; HCMV; pp72
  Monoclonal antibody p63-27 is reactive with the major immediate-early human cytomegalovirus protein pp72. This antibody is described in: Saleh MN, Stapleton JD, Khazaeli MB, LoBuglio AF, “Generation of a human anti-idiotypic antibody that mimics the GD2 antigen.” Journal of Immunology 1993; 151(6):3390-8.
U1992-0035 Murine Monoclonal Antibody 7-17 Human cytomegalovirus; HCMV; virus neutralization; AD-1 antigenic doman
  Murine monoclonal antibody 7-17 was developed against human cytomegalovirus (HCMV). This antibody exhibits complement independent neutralization of HCMV. This antibody also defines the AD-1 antigenic domain of HCMV. This antibody is described in Britt WJ, Auger D, “Synthesis and processing of the envelope gp55-116 complex of human cytomegalovirus.” Journal of Virology 1986; 58(1):185-91.
U1992-0042 Immunosuppressive Antibodies to Antigen Receptors on Human B Cells Human B cell antigen receptor
  These mouse monoclonal antibodies bind to an exposed determinant on the immunoglobulin (Ig)-associated proteins present on the surface of human B cells. These antibodies are described in: Nakamura T, Kubagawa H, Cooper MD., “Heterogeneity of immunoglobulin-associated molecules on human B cells identified by monoclonal antibodies.” Proceedings of the National Academy of Sciences of the United States of America 1992; 89(18):8522-6.
U1992-0043 Monoclonal Antibodies Against Cytomegalovirus

Cytomegalovirus; CMV; capsid; tegument; gB; gH; IE-1; IE-2

  This collection of monoclonal antibodies binds to cytomegalovirus components including capsid, tegument, gB, gH, IE-1, IE-2 and non-structural proteins. Additional information on the available antibodies and their reactivity can be provided upon request.
U1992-0049 Monoclonal Antibody to Tubulin Β-tubulin; human; rat; mouse; bovine
  The 5H1 monoclonal antibody reacts with β-tubulin. Specifically, it has been shown to react with human, rat, mouse, and bovine β-tubulin. It does not cross-react with α-tubulin. Wang Y, Loomis PA, Zinkowski RP, Binder LI, “A novel tau transcript in cultured human neuroblastoma cells expressing nuclear tau.” Journal of Cell Biology 1993; 121(2):257-67.
U1992-0050 Monoclonal Antibodies P6327 & 2819 Against Cytomegalovirus Human cytomegalovirus; HCMV; pp73; p68
  Monoclonal antibody p63-27 is reactive with the major immediate-early human cytomegalovirus (HCMV) protein pp72. Antibody 28-19 reacts with p68 which is found in virions and both the nuclear and cytoplasmic fractions of infected cells. These antibodies are described in the following papers:

Boppana SB, Smith RJ, Stagno S, Britt WJ, “Evaluation of a microtiter plate fluorescent-antibody assay for rapid detection of human cytomegalovirus infection.” J Clin Microbiol. 1992; 30(3):721-3.

Britt WJ, Vugler L, “Structural and immunological characterization of the intracellular forms of an abundant 68,000 Mr human cytomegalovirus protein.” J Gen Virol. 1987; 68 (Pt 7):1897-907.
U1993-0008 Monoclonal Antibodies to G-protein Subtypes Goα and Gαi1 GTP-binding protein; G-protein; Goα; Gαi1
  These monoclonal antibodies react to GTP-binding protein (G-protein) subtypes Goα and Gαi1. These antibodies are described in: Li X, Mumby SM, Greenwood A, Jope RS, “Pertussis toxin-sensitive G protein alpha-subunits: production of monoclonal antibodies and detection of differential increases on differentiation of PC12 and LA-N-5 cells.” Journal of Neurochemistry 1995; 64(3):1107-17.
U1993-0013 Monoclonal Antibody Against Fibroblast-Type Collagenase Human fibroblast-type collagenase
  This hybridoma cell line produces a monoclonal antibody that recognizes human fibroblast-type collagenase, an enzyme that is important to understanding a number of diseases, including arthritis, cancer, wound healing, and periodontal disease. There are both research and diagnostic uses for this antibody.
U1993-0016 Monoclonal Antibodies to Thrombospondin Thrombospondin
  This is a collection of monoclonal antibodies to thrombospondin stripped of associated TGF-β activity. These antibodies are described in: Schultz-Cherry S, Murphy-Ullrich JE, “Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism.” Journal of Cell Biology 1993; 122(4):923-32.
U1993-0026 Hybridoma Clones Producing Monoclonal Antibodies Against PspA Pneumococcal surface protein A; PspA
  This collection of hybridomas (Xi64, Xi126 and XiR278) produce monoclonal antibodies that recognize different epitopes of pneumococcal surface protein A (PspA). These antibodies are described in: McDaniel LS, Scott G, Kearney JF, and Briles DE, “Monoclonal antibodies against protease-sensitive pneumococcal antigens can protect mice from fatal infection with Streptococcus pneumoniae.” Journal of Experimental Medicine 1984; 160(2):386-97.
U1993-0073 Anti-Fas Antibody Fas
  The monoclonal antibody 2A36 demonstrates high affinity binding to Fas. This monoclonal antibody was produced by immunizing mice with a fusion protein incorporating the extracellular domain of Fas fused to human IgG1. This monoclonal antibody shows no reactivity with IgG1.
U1994-0004 Antibodies to Detect Nitrotyrosine in Biological Samples Nitrotyrosine; oxidative damage; arthritis
  These monoclonal and polyclonal antibodies detect nitrotyrosine antibodies in biological samples. Nitrotyrosine has been shown to be a marker for oxidative damage and inflammation as well as an indicator of cancer, arthritis and atherosclerosis. These antibodies are described in; Beckmann JS, Ye YZ, Anderson PG, Chen J, Accavitti MA, Tarpey MM, White CR. “Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry.” Biological Chemistry Hoppe-Seyler 1994; 375(2):81-8.
U1994-0026 Monoclonal Antibodies Against Human IgD Human IgD heavy chain
  This monoclonal antibody (clone IA6-2) reacts with the heavy chain of human IgD expressed on B cells. This antibody is described in: Baier G, Baier-Bitterlich G, Looney DJ, Altman A, “Immunogenic targeting of recombinant peptide vaccines to human antigen-presenting cells by chimeric anti-HLA-DR and anti-surface immunoglobulin D antibody Fab fragments in vitro.” Journal of Virology 1995; 69(4):2357-65.
U1994-0027 Monoclonal Antibodies Against Human CD89 and Human B29 Human CD89; human B29; Fc alpha receptor; FCAR
  Hybridoma clone CB3-1 produces a mouse anti-human CD79β (B29, Igβ) antibody. (Nakamura T, Kubagawa H, Cooper MD, “Heterogeneity of immunoglobulin-associated molecules on human B cells identified by monoclonal antibodies.” PNAS 1992 89(18):8522-6.)

Hybridoma clone A3 produces antibodies that detect human CD89, also known as Fc alpha receptor FCAR, which is present on a number of cell types, including neutrophils, monocytes, macrophages, and eosinophils. (Monteiro RC, Kubagawa H, Cooper MD, “Cellular distribution, regulation, and biochemical nature of an Fc alpha receptor in humans.” Journal of Experimental Medicine 1990; 171(3):597-613.
U1994-0028 Monoclonal Antibodies Against Mouse Pre-B Cells< Pre-B-cells
  The rat anti-mouse Pre-B-cell monoclonal antibody (Clone BP-1) recognizes mouse Pre-B-cells. This antibody is described in: Cooper MD, Mulvaney D, Coutinho A, Cazenave PA, “A novel cell surface molecule on early B-lineage cells.” Nature 1986; 321(6070):616-8.
U1994-0029 Monoclonal Antibodies Against Mouse IgD and Mouse CD38 CD38; CD16/32
  The antibodies produced by clones 90 and 93 react with mouse CD38 and mouse CD16/32, respectively. Oliver AM, Martin F, Kearney JF, “Mouse CD38 is down-regulated on germinal center B cells and mature plasma cells.” Journal of Immunology 1997; 158(3):1108-15.

The antibodies produced by clone 11-26 react with mouse IgD.
U1994-0033 Monoclonal Antibody to huLSP1 Human lymphocyte specific protein 1; juLSP1
  The monoclonal antibody 7B3.4 is capable of identifying/quantifying human lymphocyte specific protein 1 (huLSP1). This monoclonal antibody is also suitable for use in the diagnosis of neutrophil actin dysfunction with abnormalities in 47kD and 89kD proteins (NAD 47/89).
U1994-0036 Anti-Murine Fas Monoclonal Antibody Fas; Fas-ligand
  These antibodies recognize the murine forms of both Fas and Fas ligand. The anti-fas monoclonal antibody recognizes both the normal and mutant forms of the fas antigen by flow cytometry and immunoprecipitation. This antibody is unique in that is able to recognize the mutant, non-functional fas antigen on lpr cells. The anti-murine fas ligand antibody recognizes murine fas ligand is able to block fas-ligand induced apoptosis.
U1994-0054 Polyclonal Antibodies to Purified Renal Epithelial Na+ Channels Renal epithelial Na+ channels
  This polyclonal antibody was raised against purified renal epithelial Na+ channels in New Zealand White rabbits. This antibody is further described in Sorscher EJ, Accavitti MA, Keeton D, Steadman E, Frizzell RA, and Benos DJ. "Antibodies against purified epithelial sodium channel protein from bovine renal papilla." The American Journal of Physiology 255:C835-C843 (1988).
U1994-0057 Monoclonal Antibodies Against Chicken Antigens Chicken antigens; CD3; CD4; CD8; T-cell receptor-1; T-cell receptor-3
  This collection of mouse monoclonal antibodies contain clones that react to chicken CD3, CD4, CD8, T-cell receptor-1 and T-cell receptor-3. These antibodies are described in the following papers:

Bucy RP et al., “Cytoplasmic CD3+ surface CD8+ lymphocytes develop as a thymus-independent lineage in chick-quail chimeras.” Eur J Immunol. 1989; 19(8):1449-55.

Coltey M et al., “Analysis of the first two waves of thymus homing stem cells and their T cell progeny in chick-quail chimeras.” J Exp Med. 1989; 170(2):543-57.

Chan MM, Chen CL, Ager LL, Cooper MD, “Identification of the avian homologues of mammalian CD4 and CD8 antigens.” J Immunol. 1988; 140(7):2133-8.
U1994-0071 Monoclonal Antibody 12A12.D7 to TGFb Transforming growth factor beta; TGFβ
  Monoclonal antibody 12A12.D7 recognizes transforming growth factor beta (TGFB). This is an IgG2a murine monoclonal antibody with specificity for the TGFB1 isoform. This antibody is able to can be used for neutralization, immunoprecipitation, Western blotting, immunostaining, affinity purification and enzyme-linked immunoassays. This antibody also neutralizes a high molecular weight form of TGFB produced by some human brain tumor cells. This monoclonal antibody is further described in Lyon E, Gillespie GY. "Monoclonal antibodies to glioma-derived growth factor(s)." Hybridoma 13:15-20 (1994).
U1995-0012 Antibodies To A Human Enzyme Xanthine Oxidoreductase Xanthine oxidoreductase
  These antibodies (monoclonal and polyclonal) bind to human xanthine oxidoreductase, (xanthine dehydrogenase + xanthine oxidase) a complex enzyme that catalyzes the oxidation of hypoxanthine to xanthine, subsequently producing uric acid.
U1995-0034 Monoclonal Antibody Against Tau-5 Tau
  This monoclonal antibody binds to the microtubule-associated protein tau which is present in oligodendrocytes. This antibody is described in: LoPresti P, Szuchet S, Papasozomenos SC, Zinkowski RP, Binder LI. “Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes.” Proceedings of the National Academy of Sciences of the United States of America 1995; 92(22):10369-73.
U1995-0054 Monoclonal Antibodies Against Mouse CD5, CD16/32, CD24/HSA, BP-1, BiP Mouse CD5; CD16/32; CD24/HAS; BP-1; BiP
  This collection of rat monoclonal antibodies detects various murine differentiation antigens. References and additional information on specific antibodies available on request.
U1995-0058 Monoclonal Antibodies Against Fibrillin (11C1) & Type II Collagen Fibrillin; type II collagen
  The monoclonal antibody against fibrillin binds to fibrillin-1. This antibody shows no reaction to fibrillin-2. The monoclonal antibodies against type II collagen each recognize distinct epitopes of type II collagen from human, bovine and murine sources. These antibodies are described in the following papers;

Wright DW, McDaniels CN, Swasdison S, Accavitti MA, Mayne PM, Mayne R, “Immunization with undenatured bovine zonular fibrils results in monoclonal antibodies to fibrillin.” Matrix Biol. 1994; 14(1):41-9.

Mayne R, Mayne PM, Ren Z, Accavitti MA, Gurusiddappa S, Scott PG. “Monoclonal antibody to the aminotelopeptide of type II collagen: loss of the epitope after stromelysin digestion.” Connect Tissue Res. 1994; 31(1):11-21.
U1996-0065 Anti-VEGF Monoclonal Antibody Vascular endothelial growth factor; VEGF
  This monoclonal antibody binds to vascular endothelial growth factor and is made from clone 5C3F8. Monoclonal antibody 5C3.F8 was produced by immunizing BALB/c mice with multiple sequential injections of purified human glioma-derived VPF/VEGF and a VPF/VEGF peptide containing amino acids 35 through 58. Further details about this monoclonal antibody can be found in Goldman CK, Bharara S, Palmer CA, Vitek J, Tsai JC, Weiss HL, and Gillespie GY. "Brain edema in meningiomas is associated with increased vascular endothelial growth factor expression." Neurosurgery 40:1269-1277 (1997).
U1996-0069 Monoclonal Antibody Against S-100 Protein S-100 protein
  This monoclonal antibody to S100 stains Schwannomas, ependymomas, astrogliomas, almost all benign and malignant melanomas and their metastases. This monoclonal antibody is described in: Loeffel SC, Gillespie GY, Mirmiran SA, Miller EW, Golden P, Askin FB, Siegal GP, “Cellular immunolocalization of S100 protein within fixed tissue sections by monoclonal antibodies.” Archives of Pathology and Laboratory Medicine 1985; 109(2):117-22.
U1997-0019 Monoclonal Antibodies to Bacillus Subtilis Spores Bacillus subtilis spores
  These are hybridomas produce monoclonal antibodies that react with spores from the gram positive organism B. subtilis which may have reactivity against all Bacillus sp. spores. At least two of these antibodies may actually kill the spores directly in vitro.
U1997-0024 Monoclonal Antibodies Against Chicken Type IX Collagen Chicken type IX collagen
  These monoclonal antibodies react to chicken type IX collagen with high specificity. The antibodies are described in: Irwin MH, Silvers SH, Mayne R, “Monoclonal antibody against chicken type IX collagen: preparation, characterization, and recognition of the intact form of type IX collagen secreted by chondrocytes.” Journal of Cell Biology 1985; 101(3):814-23.
U1997-0034 Polyclonal (Chicken) Antibodies to Urodilatin (CDD/ANP 95-126) Urodilatin
  Urodilatin is a potent hormone-like substance that causes an increase in urine and sodium excretion. The action of this protein may have important implications in cardiovascular disease, obstructive sleep apnea, stroke, asthma, maintaining fluid balance, renal function, including homeostasis and water conservation in spaceflight. At present, there is no way to measure the quantity of this substance in the body. The production of a polyclonal antibody to urodilatin will permit measurement of this protein using standard radioimmunoassay or ELISA techniques.
U1997-0035 Monoclonal Antibodies to Urodilatin (CDD/ANP 95-126) Urodilatin
  The purpose of the initiative was to generate a perpetual cell line using the mouse for the production of monoclonal antibodies specific for urodilatin. The development of a perpetual cell line for the production of monoclonal antibodies will provide a reliable source of monoclonal antibodies for the intended studies.
U1997-0075 Monoclonal antibodies against synaptic junctional proteins SAP97, SAP102, GKAP, Bassoon Synaptic junction proteins; SAP97; SAP 102; Bassoon
  These monoclonal antibodies have been generated against a novel set of proteins found at synaptic junction between neurons in the developing and mature brain. The antigens used to generate these monoclonal antibodies are derived from rat. These antibodies represent a novel class of molecular probes that can be used to examine the synaptic junction and not just synaptic vesicles localized at the presynapse. The antigens are a unique group of proteins involved in the recruitment and clustering of ion channels at synaptic junctions.
U1998-0038 Anti-Mr 72,000 gelatinase monoclonal antibody VB3IB4 Human 72K gelatinase protein; MMP-2
  VB3IB4 is a monoclonal antibody raised against the native human Mr 72,000 gelatinase protein. It can be used in research and diagnostic techniques to determine the level of Mr 72,000 gelatinase protein. This monoclonal antibody recognizes this protein in multiple laboratory techniques including Western blots, ELISA and immunoprecipitation.
U1999-0001 Monoclonal anti-Nck Antibody 8.8 NcK; adapter protein; signaling pathways
  This monoclonal antibody (8.8) recognizes NcK proteins (NcK-1 and NcK-2). Nck is a SH3- and SH2-containing adaptor protein implicated in coordinating various signaling pathways, including those of growth factor receptors and cell adhesion receptors. This antibody is described in: Tu Y, Li F, Wu C, “Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways.” Molecular Biology of the Cell 1998; 9(12):3367-82.
U1999-0024 Monoclonal Antibodies to Human Fibroblast Procollagenase Human fibroblast procollagenase; matrix metalloproteinase; MMP; urokinase
  This collection of monoclonal antibodies (35 hybridoma lines) was raised against matrix metalloproteinases and urokinase. These antibodies recognize matrix metalloproteinases (MMPs) and urokinase in multiple laboratory techniques such as Western blots, ELISA and immunoprecipitation. A full list of antibodies and additional information is available upon request.
U1999-0048 Monoclonal Antibodies Against Human Adenovirus Fiber Protein Human adenovirus fiber protein
  These antibodies provide valuable research tools to assess the presence and structure of adenovirus fiber and whether or not it is the native state. These antibodies are described in: Hong JS, Engler JA, “The amino terminus of the adenovirus fiber protein encodes the nuclear localization signal.” Virology 1991; 185(2):758-67.
U1999-0061 An Idiotypic Antibody Vaccine for Multiple Sclerosis Myelin basic protein; MBP; experimental allergic encephalomyelitis; EAE
  The monoclonal antibody F28C4 has epitope specificity to myelin basic protein, residues 1-9. Vaccination with F28C4 protects animals against the induction of the model of MS, termed experimental allergic encephalomyelitis (EAE). The protection has been observed in different species (mouse vs. rat) and different strains of mice, including outbred animals. This monoclonal antibody is described in Maier CC, Galin FS, Jarpe MA, Jackson P, Krishna NR, Gautam AM, Zhou SR, Whitaker JN, Blalock JE. "A V lambda x-bearing monoclonal antibody with similar specificity and sequence to encephalitogenic T cell receptors." Journal of Immunology 153:1132-1140 (1994).
U2000-0007 Monoclonal antibody anti-GHR-ext. Rabbit growth hormone receptor; GHR
  This monoclonal antibody binds to rabbit growth hormone receptor (GHR) expressed in bacteria. The monoclonal antibody reacts well with rabbit and human GHRs. This antibody is described in: Kim SO, Jiang J, Yi W, Feng GS, Frank SJ, “Involvement of the Src homology 2-containing tyrosine phosphatase SHP-2 in growth hormone signaling.” Journal of Biological Chemistry 1998; 273(4):2344-54.
U2000-0012 Ubiquitin, monoclonal anybody 6C1.17 Ubiquitin
  This mouse monoclonal antibody recognizes ubiquitin. This monoclonal antibody can be used in Western blots, immunoprecipitation and immunocytochemistry. This antibody is described in: Chen L, Smith L, Accavitti-Loper MA, Omura S, Bingham Smith J, “Ubiquitylation and destruction of endogenous c-mycS by the proteasome: are myc boxes dispensable?” Archives of Biochemistry and Biophysics 2000; 374(2):306-12.
U2000-0076 Monoclonal anti-ILK antibody Integrin-linked kinase; ILK; signaling pathways
  This monoclonal antibody detects integrin-linked kinase (ILK), a ubiquitously expressed protein serine/threonine kinase that has been implicated in integrin-, growth factor- and Wnt-signaling pathways. This antibody is described in: “Li F, Zhang Y, Wu C, “Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats.” Journal of Cell Science 1999; 112 (Pt 24):4589-99.
U2000-0081 Monoclonal Antibodies against p115 Transcytosis-associated protein; TAP; p115
  These monoclonal antibodies detect transcytosis-associated protein (TAP, also known as p115) which is found on transytotic vesicles (TCVs) and is required for their fusion with the target membrane. These antibodies are described in: Barroso M, Nelson DS, Sztul E, “Transcytosis-associated protein (TAP)/p115 is a general fusion factor required for binding of vesicles to acceptor membranes.” Proceedings of the National Academy of Sciences of the United States of America 1995; 92(2):527-31.
U2000-0092 Anti-GKLF monoclonal antibody( clone designated IE2 or IE5) GKLF/KLF4; zinc finger protein
  These monoclonal antibodies detect the zinc finger protein GKLF/KLF-4 which has been identified as a novel oncogene. Although GKLF is normally expressed in superficial, differentiating epithelial cells of the skin, oral mucosa, and gut, expression is consistently up-regulated in dysplastic epithelium and in squamous cell carcinoma of the oral cavity. These antibodies are described in: Foster KW, Frost AR, McKie-Bell P, Lin CY, Engler JA, Grizzle WE, Ruppert JM, “Increase of GKLF messenger RNA and protein expression during progression of breast cancer.” Cancer Research 2000; 60(22):6488-95.
U2000-0095 Antibodies to the gM/gN complex of Human Cytomegalovirus Human cytomegalovirus; CMV; gM/gN complex
  This is a murine monoclonal antibody (14-16A) which defines a unique epitope which is assembled following complex formation between gM (UL 100) and gN (UL73) of human cytomegalovirus (HCMV). This antibody is described in: Britt WJ and Auger D, “Identification of a 65 000 dalton virion envelope protein of human cytomegalovirus.” Virus Research 1985; 4(1):31-6.
U2001-0017 Anti-human TACI Monoclonal Antibodies B lymphocyte stimulator receptor; BLyS; TACI; BCMA
  These antibodies recognize soluble and membrane-bound forms of B lymphocyte stimulator (BLyS) receptors. These antibodies are described in: Zhang J, Roschke V, Baker KP, Wang Z, Alarcón GS, Fessler BJ, Bastian H, Kimberly RP, Zhou T, “Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus.” Journal of Immunology 2001; 166(1):6-10.
U2001-0025 6CI Monoclonal Antibody Paired immunolglobulin-like receptors; PIR-A; PIR-B
  6CI is a rat hybridoma that produces monoclonal antibodies to mouse paired immunoglobulin-like receptors (PIR)-A and –B. This monoclonal antibody is described in: Kubagawa H, Chen CC, Ho LH, Shimada TS, Gartland L, Mashburn C, Uehara T, Ravetch JV, Cooper MD, “Biochemical nature and cellular distribution of the paired immunoglobulin-like receptors, PIR-A and PIR-B.” The Journal of Experimental Medicine 1999; 189(2):309-18.
U2001-0027 AD2 Monoclonal Antibodies Human CD73; 5’ ectonucleotidase
  This AD2 monoclonal antibody reacts with human CD73, a 5’ectonucleotidase that converts 5’adenosine monophosphate to adenosine. CD73 is expressed on the surface of endothelial cells, as well as B and T cells, including CD4+Foxp3+ regulatory T cells. This antibody is described in: Nakamura T, Kubagawa H, Ohno T, Cooper MD, “Characterization of an IgM Fc-binding receptor on human T cells. Journal of Immunology 1993; 151(12):6933-41.
U2001-0060 Monoclonal antibodies to sperm protein 17 (Sp17): UAB-Sp17-2, UAB-Sp17-23, UAB-Sp17-74 Human sperm protein 17; Sp17; mouse Sp17
  These three mouse monoclonal antibodies (UAB-Sp17-2, UAB-Sp17-23 and UAB-Sp17-74) recognize human sperm protein 17 (sp17). They also recognize mouse Sp17. The antibodies work in immunostaining of formalin fixed and paraffin-embedded tissues, frozen sections, Western blots and ELISA. Sp17 is normally expressed exclusively in human testis and sperm, however, it has also been found to be expressed in tumor cells, including ovarian cancer and multiple myeloma.
U2001-0062 CTD110.6 Monoclonal Antibody Beta-O-linked N-acetylglucosamine; O-GlcNAc
  Monoclonal antibody CTD110.6 reacts specifically with beta-O-linked N-acetylglucosamine (O-GlcNAc). This IgM antibody recognizes o-GlcNAc in beta-O-glycosidic linkage to both serine and threonine, however, it exhibits no cross reactivity with alpha-linked Ser-O-linked N-acetylgalactosamine or N-linked oligosaccharides on ovalbumin and immunoglobulin. This antibody readily detects in vivo changes in O-GlcNAc modification. This antibody is further described in Comer FI, Vosseller K, Wells L, Accavitti MA, and Hart GW. "Characterization of a mouse monoclonal antibody specific for O-linked N-acetylglucosamine." Analytical Biochemistry 293:169-77 (2001).
U2001-0109 Antibody for the catalytic subunit of glutamate-cysteine ligase Glutamate-cysteine ligase; catalytic subunit
  This polyclonal antibody recognizes the catalytic subunit of glutamate-cysteine ligase. This antibody is described in Liu RM, Gao L, Choi J, and Forman HJ. “gamma-glutamylcysteine synthetase: mRNA stabilization and independent subunit transcription by 4-hydroxy-2-nonenal.” The American Journal of Physiology 1998; 275(5 Pt 1):L861-9.
U2002-0005 SA-DA4 Human IgM heavy chain; CH1 domain
  This is a mouse IgG monoclonal antibody to human IgM heavy chain. It binds to the CH1 domain with very high affinity and is useful for immunofluorescence detection of human IgM on B cells and in serum. It can also be used to detect IgM in frozen tissue sections.
U2002-0008 Production of an anti-mouse VpreB monoclonal antibody VpreB
  These monoclonal antibodies detect the human VpreB molecule. These antibodies are described in Wang YH, Nomura J, Faye-Petersen OM, Cooper MD, “Surrogate light chain production during B cell differentiation: differential intracellular versus cell surface expression.” Journal of Immunology 1998; 161(3):1132-9.
U2002-0025 Mouse monoclonal antibody/hybridoma cell line mc8C5-4 RVS SRA SU SR-A rous sarcoma virus; RSV; envelope glycoprotein; gp85; gp37
  The hybridoma cell line mc8C5-4 was generated after immunizing BALB/c mice with NIH3T3-EnvA cells stably expressing the subtype SR-A Rous Sarcoma Virus (RSV) envelope glycoprotein which is a heterodimer comprised of gp85(SU) and gp37(TM). The monoclonal antibodies produced by this hybridoma cell line can be used for numerous applications including immunofluorescence staining of fixed or unfixed RSV-Env-expressing cells, flow cytometry analyses, immunoprecipitations and Western blotting. This hybridoma and monoclonal antibody are described in Ochsenbauer-Jambor C, Delos SE, Accavitti MA, White JM, Hunter E. "Novel monoclonal antibody directed at the receptor binding site on the avian sarcoma and leukosis virus Env complex." Journal of Virology 76:7518-7527 (2002).
U2002-0033 Hybridomas making antibodies to group B streptococcal antigens Group B streptococcal antigens
  This is a collection of 60 hybridomas producing monoclonal antibodies against group-B streptococcal antigens. The antibodies produced by these hybridomas have been characterized to varying degrees. All have been tested for their ability to bind specific group-B streptococcal antigens and the majority has had their Ig isotype determined. Please contact us for additional information.
U2002-0035 IAD6-2 Human IgD heavy chain
  Mouse IgG antibody to human IgD heavy chain. This monoclonal antibody is useful for immunofluorescence detection of human IgD on B cells and in serum. It can be used to detect IgD in frozen tissue sections.
U2002-0036 Hybridoma 11-26c Mouse IgD heavy chain
  Rat monoclonal antibody to a non-allotypic determinant on mouse IgD heavy chain. This monoclonal antibody is useful for immunofluorescence detection of mouse IgD on B cells. It can be used to detect IgD in frozen tissue sections.
U2002-0037 Hybridoma 11-44-2-11 Mouse IgA heavy chain
  This is a rat monoclonal antibody to a non-allotypic determinant on mouse IgA heavy chain. This monoclonal antibody is useful for immunofluorescence detection of mouse IgA on B cells and in blood and secretions. It can be used to detect IgA in frozen tissue sections.
U2002-0038 Hybridoma JC5-1 Mouse lambda light chain; B-cells
  This is a rat monoclonal antibody to mouse lambda light chain. This monoclonal antibody is useful for immunofluorescence detection of mouse lambda light chains on B cells. It can be used to detect lambda light chains in frozen tissue sections.
U2002-0042 GA1 Monoclonal Antibody to Cystic Fibrosis Transmembrane Regulator Cystic fibrosis transmembrane regulator protein; CFTR
  This monoclonal (GA1) antibody was raised against the C-terminal of recombinant human cystic fibrosis transmembrane regulator (CFTR) protein, corresponding to amino acids 1387-1480. This antibody is described in Cormet-Boyaka E, Di A, Chang SY, Naren AP, Tousson A, Nelson DJ, Kirk KL, “CFTR chloride channels are regulated by a SNAP-23/syntaxin 1A complex.” PNAS 2002; 99(19):12477-82.
U2002-0046 Anti-MIBP antibody 5B4.7 and hybridoma cells expressing the antibody Muscle integrin binding protein; MIBP
  Anti-MIBP antibody 5B4.7 recognizes muscle integrin binding protein (MIBP). This antibody is described in: Li J, Mayne R, Wu C, “A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation.” The Journal of Cell Biology 1999; 147(7):1391-8.
U2003-0080 Anti-murine complement protein antibodies (anti-C5a, anti-C3a, anti-C3aR, anti-factor B) Complement protein; C5a; C3a; C3aR; factor B


These monoclonal antibodies have been produced against murine complement proteins. The specific antigens that this collection of monoclonal antibodies recognize are C3a receptor (C3aR), C3a, C5a and factor B. These monoclonal antibodies were produced using chickens.
U2003-0084 Recombinant SARS proteins and antibodies against them Severe acute respiratory syndrome; SARS; spike protein; coronavirus
  These monoclonal antibodies recognize the spike protein of severe acute respiratory syndrome (SARS) coronavirus (CoV). Some of these antibodies exhibit neutralizing activity against SARS CoV infection in cell culture. These antibodies are described in; Zhou T, Wang H, Luo D, Rowe T, Wang Z, Hogan RJ, Qiu S, Bunzel RJ, Huang G, Mishra V, Voss TG, Kimberly R, Luo M, “An exposed domain in the severe acute respiratory syndrome coronavirus spike protein induces neutralizing antibodies.” Journal of Virology 2004; 78(13):7217-26.
U2004-0069 Unique Cellular Reactivity of AM 9.4 Anti-Fcα/µR Monoclonal Antibody Human Fcalpha/mu receptor; Fc receptor; IgA; IgM;
  This monoclonal antibody binds to the Fc receptor for IgA and IgM (Fc/R) which may play a pivotal role in systemic and mucosal immunity. This antibody is described in: Kikuno K, Kang DW, Tahara K, Torii I, Kubagawa HM, Ho KJ, Baudino L, Nishizaki N, Shibuya A, Kubagawa H, “Unusual biochemical features and follicular dendritic cell expression of human Fcalpha/mu receptor.” European Journal of Immunology 2007; 37(12):3540-50.
U2005-0030 Apoptosis-related recombinant proteins and monoclonal antibodies Apoptosis; Bcl-2; XIAP; IAP-1; IAP-2; FADD; BLyS
  This collection of monoclonal antibodies has been raised against a number of recombinant proteins that have been implicated in the apoptosis pathway. These proteins include Bcl-2, Bcl-xl, XIAP, IAP-1, IAP-2, FADD and BLyS. A full list of antibodies is available upon request.
U2005-0033 The F95 Monoclonal Antibody Against Peptidyl Citrulline Peptidyl citrulline
  Using hybridoma technology, an IgM monoclonal antibody (mAb), designated as F95, was developed against a deca-citrullinated peptide (DCP) consisting of 10 citrulline residues and a carboxyl Gly-Gly-Cys through which DCP was covalently linked to an activated carrier protein, keyhole limpet hemocyanin (KLH). This antibody is described in: Nicholas AP, Whitaker JN, “Preparation of a monoclonal antibody to citrullinated epitopes: its characterization and some applications to immunohistochemistry in human brain.” Glia, 2002; 37(4):328-36.
U2006-0042 Selective Antibodies Targeting the Inhibitory CD32B Fc Receptor CD32B Fc receptor; human FcγRIIb
  Monoclonal antibody 4F5, a murine IgG1, was generated in BALB/c mice using the Escherichia coli-produced recombinant extracellular domain (EC) of human FcγRIIb as an immunogen. This antibody is described in: Su K, Yang H, Li X, Li X, Gibson AW, Cafardi JM, Zhou T, Edberg JC, Kimberly RP, “Expression profile of FcgammaRIIb on leukocytes and its dysregulation in systemic lupus erythematosus.” Journal of Immunology 2007; 178(5):3272-80.
U2007-0082 Anti-Mouse SP-1 (Clone EG35 4) and Anti-Mouse CD22 (Clone C2) SP-1; CD22
  Additional information on these antibodies available upon request.
U2008-0048 BRMS1 Monoclonal Antibodies Breast cancer metastasis suppressor 1; BRMS1
  These monoclonal antibodies detect breast cancer metastasis suppressor 1 (BRMS1), a member of a class of proteins that suppress metastasis without blocking tumoringenicity. These antibodies have been used in immunoblotting, ELISA, chromatin immunoprecipitation (ChIP) and immunoprecipitation. These antibodies are described in: Hurst DR, Xie Y, Vaidya KS, Mehta A, Moore BP, Accavitti-Loper MA, Samant RS, Saxena R, Silveira AC, Welch DR. “Alterations of BRMS1-ARID4A interaction modify gene expression but still suppress metastasis in human breast cancer cells.” Journal of Biological Chemistry 2008; 283(12):7438-44.
U2008-0049 KISS1 Monoclonal Antibodies KISS1; cancer metastasis
  These monoclonal antibodies detect KISS1, a member of a family of proteins that suppress metastasis without blocking tumoringenicity. These monoclonal antibodies have been used in immunoblots, ELISA, immunofluorescence and immunoprecipitation.
U2008-0056 Anti-Prolyl Endopeptidase (EC 3.4.21.26) Monoclonal Antibody Clone 9A5 Prolyl endopeptidase; EC 3.4.21.26
  This monoclonal antibody produced using purified human recombinant prolyl endopeptidase (EC 3.4.21.26). Antibodies produced by this hybridoma clone (9A5) are able to detect prolyl endopeptidase in Western blot and immunofluorescence on a variety of human cells.
U2008-0057 Anti-Prolyl Endopeptidase (EC 3.4.21.26) Monoclonal Antibody Clone 1D3 Prolyl endopeptidase; EC 3.4.21.26
  This monoclonal antibody produced using purified human recombinant prolyl endopeptidase (EC 3.4.21.26). Antibodies produced by this hybridoma clone (1D3) are able to detect prolyl endopeptidase in Western blot on a variety of human cells. Experiments with this antibody clone have found that it exhibits neutralization properties toward hPE protein.
U2008-0058 Anti-Prolyl Endopeptidase (EC 3.4.21.26) Monoclonal Antibody Clone 7B4 Prolyl endopeptidase; EC 3.4.21.26
  This monoclonal antibody produced using purified human recombinant prolyl endopeptidase (EC 3.4.21.26). Antibodies produced by this hybridoma clone (7B4) are able to detect prolyl endopeptidase in Western blot and immunofluorescence on a variety of human cells. This antibody has also been used in the development of and ELISA for the detection of prolyl endopeptidase.
U2008-0059 Anti-Prolyl Endopeptidase (EC 3.4.21.26) Monoclonal Antibody Clone 7C3

Prolyl endopeptidase; EC 3.4.21.26

  This monoclonal antibody produced using purified human recombinant prolyl endopeptidase (EC 3.4.21.26). Antibodies produced by this hybridoma clone (7C3) are able to detect prolyl endopeptidase in Western blot on a variety of human cells.
U2008-0085

Hybridoma (Rat) MZ3 Mice Antibody Specificity to CD 9 (Mouse) Tetraspanin; CD9; marginal zone; B-cells
  Marginal zone (MZ), follicular (FO), and B1 B cells form the long-lived naive B cell compartment. Monoclonal antibody MZ3 recognizes the tetraspanin CD9. CD9 expression not only distinguishes MZ B cells from FO B cells but also divided peritoneal cavity B1 cells into smaller subsets. The characterization of this antibody is described in: Won WJ, Kearney JF, “CD9 is a unique marker for marginal zone B cells, B1 cells, and plasma cells in mice.” Journal of Immunology 2002; 168(11):5605-11.
U2008-0086 Hybridoma (Rat) 19-3 with Antibody Specificity for Human Mouse TdT Terminal deoxynucleotidyl transferase; TdT; splice variant
  Hybridoma 19-3 as made by immunizing mice with recombinant terminal deoxynucleotidyl transferase (TdT). TdT is a nuclear protein that is expressed in many human acute lymphocytic leukemias. This antibody reacts with the short splice variant of both mouse and human TdT.
U2008-0087 Rat Monoclonal Hybridoma 76-E6 (Specificity Mouse BiP) Immunoglobulin binding protein; BiP; Gp78; Chaperone molecule; protein folding
  Rat monoclonal hybridoma 76-E6 (specificity Mouse BiP) was made by immunizing a rat with recombinant mouse BiP (also known as Immunoglobulin binding protein or Gp78). This is a chaperone molecule that binds to incorrectly folded or unassembled proteins. This hybridoma is described in: Bole DG, Hendershot LM, Kearney JF, “Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas.” Journal of Cell Biology 1986; 102(5):1558-66.
U2008-0093 Conformation-Specific Inhibitory Monoclonal Antibody Against the Extracellular Domain of the Growth Hormone Receptor (GHR) Growth Hormone Receptor; GHR
  This monoclonal antibody (anti-GHRex-mAb) was raised against a bacterially-expressed fusion protein that included the extracellular domain of rabbit growth hormone receptor (GHR). This antibody has been shown in vitro to block intracellular signaling induced by exposure to growth hormone on cells expressing either rabbit or human GHR.
U2009-0024 10.1 Monoclonal Antibody Specific for Mouse Paired Immunoglobulin-Like Receptors of Activating and Inhibitory Isoforms Paired immunoglobulin-like receptor; PIR-A; PIR-B
  The rat anti-paired immunoglobulin-like receptor (PIR) monoclonal antibody 10.1 is described in: Uehara T, Bléry M, Kang DW, Chen CC, Ho LH, Gartland GL, Liu FT, Vivier E, Cooper MD, Kubagawa H, “Inhibition of IgE-mediated mast cell activation by the paired Ig-like receptor PIR-B.” Journal of Clinical Investigation 2001; 108(7):1041-50.
U2009-0028 Monoclonal Antibodies Against Cytomegalovirus Cytomegalovirus; CMV
  These mouse monoclonal antibodies detect cell surface and intracellular antigens of guinea pig cytomegalovirus (gpCMV). These antibodies are described in: Britt WJ and Harrison C, “Identification of an abundant disulfide-linked complex of glycoproteins in the envelope of guinea pig cytomegalovirus.” Virology 1994; 201:294-302.
U2009-0029 1-155-2 Mouse Monoclonal Antibody to Human Lambda Immunoglobulin Light Chains human IgA1λ myeloma
  Anti-Lambda, clone 1-155-2, is derived from a hybridization of mouse P3-X63-Ag8.653 myeloma cells with cells from BALB C/J mice immunized with human IgA1λ myeloma protein and is useful for the typing of human B cells. This antibody is described in: Kubagawa H, Gathings WE, Levitt D, Kearney JF, Cooper MD, “Immunoglobulin isotype expression of normal pre-B cells as determined by immunofluorescence.” Journal of Clinical Immunology” 1982; 2(4):264-9.

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