Evelyn F. McKnight Brain Institute

Director:  J. David Sweatt, PhD

Established:  November 5, 2004

 

Mission and Demographics

The mission of the Evelyn F. McKnight Brain Institute is to advance the understanding of the biological basis of the effects of the normal aging process on the human brain’s capacity for learning and memory through fundamental research. 

The University of Alabama School of Medicine received a $5 million grant to support research in age-related memory loss from the McKnight Brain Research Foundation.  This grant established the Evelyn F. McKnight Brain Institute, which is housed in the Richard C. and Annette N. Shelby Interdisciplinary Biomedical Research Building.  Grant funds provide for faculty salaries, purchase of laboratory instrumentation, pilot research funding, and other scholarly activities related to research and study.

Center Research 

            Institute scientists will investigate the fundamental mechanisms of memory in the human brain, focusing particularly on problems of age-related memory loss.  The long-term objective is to translate basic biomedical research into treatments, medications, or other techniques that can minimize the effects of aging on learning and memory.

            Earlier this year, a total of $100,000 was awarded to three investigators for pilot research projects.  David G. Clark, MD, Assistant Professor of Neurology, will use sophisticated neuroimaging approaches to study semantic processing and brain structure in normal human aging.  Inga Kadisha, PhD, Instructor, Department of Cell Biology, will study the role of white matter pathology in age-related cognitive deficits.  Anne Theibert, PhD, Associate Professor of Neurobiology, will examine the PI3-kinase pathway and its role in dendritic spine and synapse morphogenesis in developing and aging rat hippocampus.

Training

Educational symposia and seminars on topics related to the effects of aging on learning and memory are sponsored by the Center.

 

For additional information:

            Director:  J. David Sweatt, PhD

            Phone:  205-934-0100

 

 

Approved by:  J. David Sweatt, PhD, Director           

Date:  April 15, 2008

 

 

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