Leukocyte/Endothelial Cell Adhesion Molecule (LECAM) Mutant Mouse Resource

Director: Daniel Bullard, PhD

Department/Center Association: Department of Genetics

Established: 1998

Mission

The UAB Leukocyte/Endothelial Cell Adhesion Molecule (LECAM) Mutant Mouse Resource is a core facility, previously funded by the University of Alabama Health Services Foundation, which provides many different gene targeted mouse mutations to interested UAB investigators.

Facility Description

The mice are maintained in the KAUL Animal Facilities. Health surveillance is done several times each year to ensure that these mice remain pathogen-free.

Research Information

Mice containing mutations in genes such as P-selectin, E-selectin, PSGL-1, ICAM-1, CD18, CD11a, CD11b, CD11c, and CD11d on several different strain backgrounds are available. All of these mutations are backcrossed at least 8 generations onto C57BL/6 and many are also available on several other strain backgrounds (DBA/1, PL/J, MRL/MpJ, and BALB/c).

Fees. Minimal charges apply for mouse development and procurement. Consultation regarding technical information and information regarding the appropriate probes to identify any of the noted mutations is provided upon request.

Contact Information

Core Director: Daniel Bullard, PhD

Email: dcbullard@uab.edu

Phone: 205-934-7768

Web Site: http://main.uab.edu/camrc/show.asp?durki=49148

Approved by: Daniel Bullard, PhD, Director

Date: February 23, 2008

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