Sadanandan Velu. Associate Professor
Chemistry Building 280
(205) 975-2478

Research and Teaching Interests: Organic/Medicinal Chemistry, Drug Discovery and Development, Anti-cancer and Anti-infective Agents, Structure Based Drug Design, Fragment based Drug Discovery, In-Silico Virtual Screening, Directed Combinatorial Synthesis, Structure Activity Relationship (SAR) Studies, Lead Optimization, Solution Phase Parallel Synthesis, Synthesis of Marine Natural Products and their Analogs, Development of Synthetic Methodologies

Office Hours: By appointment

  • MSc, University of Calicut, India, Chemistry
  • PhD, University of Madras, India, Organic Synthesis

Dr. Velu did his postdoctoral research at the University of Alabama and at Clemson University. He joined the Medicinal Chemistry division of the Center for Biophysical Sciences and Engineering at UAB in 1997 and worked as a Staff Scientist through 2004. He also held a joined appointment in the Chemistry department as a Research Faculty during the period, 2002-2004. He joined the Chemistry department as an Assistant Professor in August of 2004 and was tenured and promoted to Associate Professor Rank in 2010.

Dr. Velu holds co-appointments as an Associate Scientist at the UAB Comprehensive Cancer Center and the UAB Center for Clinical and Translational Sciences. His teaching responsibilities include both undergraduate and graduate level organic and medicinal chemistry courses in the department. His research interests are in organic/medicinal chemistry, drug discovery and development, anti-cancer and anti-infective agents, structure based drug design, fragment based drug discovery, in-silico virtual screening, directed combinatorial synthesis, structure activity relationship (SAR) studies, lead optimization, solution phase parallel synthesis, synthesis of marine natural products and their analogs, development of synthetic methodologies.

Curriculum Vitae

The main focus of Dr. Velu’s lab is drug discovery and development. Lab work force is mainly constituted of graduate students working towards their PhD degree, undergraduate students carrying out their senior / honors research, postdoctoral trainees and occasionally research assistants. The research projects are mainly directed towards the discovery of anti-cancer and anti-infective agents. The ongoing research projects are:

Marine Alkaloid Analogs for Breast Cancer Therapy

Marine Alkaloid Analogs for Breast Cancer TherapyIn spite of the recent advances in computational approaches for lead identification and drug discovery, natural products remain as an important source for novel anticancer agents. In addition, natural products provide drugs with unprecedented molecular structures and bioactivity that are often inaccessible by other methods, and provide templates for future drug design. Our laboratory has focused recent research on the development of novel marine natural products and their analogs for human breast cancer therapy.

Staphylococcus aureus Sortase A inhibitors

Staphylococcus aureus Sortase A inhibitorsAs bacterial pathogens develop resistance to conventional antibiotics, inhibition of bacterial surface protein display offers a novel strategy against S. aureus bacterial infections. By interrupting bacterial adherence, the initial step in the pathogenesis of bacterial infections, S. aureus will be poorly equipped to cause the disease and may be more effectively cleared by host innate immune defenses and/or by antibiotics. We hypothesize that the inhibitors of the surface enzyme, sortase will render S. aureus non-adherent and consequently less virulent.

Voltage Gated Sodium Channel Blockers

The ability to prevent or slow down metastasis would represent a major breakthrough in cancer therapy and dramatically improve life expectancies of cancer patients. Fortunately, our increasing understanding of the metastatic process has recently resulted in the discovery of new potential drug targets to prevent / slow metastasis. One such target is the voltage-Gated Sodium Channels (VGSC). This project is directed towards targeting VGSCs for developing drugs that prevent / slow down breast and prostate cancer metastasis.

Trypanosoma Cruzi DHFR inhibitors

velu research 3Chagas disease is caused by the protozoan parasite Trypanosoma cruzi (T. cruzi). Since the dihydrofolate reductase (DHFR) activity of T. cruzi (TcDHFR) is essential for the parasite, it represents a potential target for the rational drug design for Chagas disease. In order to facilitate the design of selective inhibitors of TcDHFR we have initiated a structure based drug design using the X-ray crystal structure of T. cruzi DHFR. Subtle differences in the active sites of TcDHFR and hDHFR are taken in to consideration in order to design more selective and potent inhibitors of TcDHFR.
Dr. Velu teaches both undergraduate and graduate level courses in the Chemistry department of UAB. The main focus of his teaching is in the areas of Organic Chemistry, Natural Products, Medicinal Chemistry and Drug Discovery. The following is the listing of all courses currently offered by Dr. Velu.

Undergraduate Courses
  • CH 235: Organic Chemistry I
  • CH-237: Organic Chemistry II
Graduate Courses
  • CH 701: Foundations of Organic and Inorganic Chemistry
  • CH 772: Chemistry of Natural Products
  • CH 732: Organic Reactions and Synthesis
  • Ehrhardt A, Chung WJ, Pyle LC, Wang W, Nowotarski K, Mulvihill CM, Ramjeesingh M, Hong J, Velu SE, Lewis HA, Atwell S, Aller S, Bear CE, Lukacs GL, Kirk KL, and Sorscher EJ, Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop, J. Biol. Chem., 2015, IN PRESS.
  • Singh T, Gupta NA, Xu S, Prasad R, Velu SE and Katiyar SK, Honokiol inhibits the growth of head and neck squamous cell carcinoma by targeting and firm binding with epidermal growth factor receptor, Oncotarget, 2015, 6, 21268-21282. 
  • Nijampatnam B, Dutta S and Velu SE, Recent developments in the isolation, synthesis, and bioactivities of bispyrroloquinone alkaloids of marine origin, Chin. J. Nat. Med., 2015,13, 561-577.
  • Zhang Q, Nguyen T, McMichael M, Velu SE, Zou J, Zhou X and Wu H, New Small Molecule Inhibitors of Dihydrofolate Reductase inhibit Streptococcus mutans,Int. J. Antimicro. Ag., 2015, 46, 174-182. 
  • Vayalil PK, Oh J-Y, Zhou F, Diers, AR, Smith, MR, Golzarian H, Oliver, PG, Smith RAJ, Murphy MP,  Velu SE and Landar A,  A Novel Class of Mitochondria-Targeted Soft Electrophiles Modifies Mitochondrial Proteins and Inhibits Mitochondrial Metabolism in Breast Cancer Cells through Redox Mechanisms, PLoS One, 2015, 10:e0120460. 
  • Yu J-X, Voruganti S, Li D-D, Qin J-J, Nag S, Xu S, Velu SE, Wang W and Zhang R, Development and validation of an HPLC-MS/MS analytical method for quantitative analysis of TCBA-TPQ, a novel anticancer makaluvamine analog, and application in a pharmacokinetic study in rats, Chin. J. Nat. Med.,2015, 13, 554-560.
  • Xu S, Nguyen T, Pomilio I, Vitale, MC and Velu S.E, Total Synthesis of Calothrixins A and B via Oxidative Radical Reaction of Cyclohexenone with Aminophenanthridinedione, Tetrahedron, 2014, 70, 5928-5933.
  • Shim E-H, Livi CB, Rakheja D,  Tan J, Benson D,  Parekh V,  Kho E-Y, Ghosh AP,  Kirkman R, Velu SE., Dutta S, Chenna B,  Rea SL, Mishur RJ, Li Q,  Johnson-Pais TL, Guo L,  Bae S, Wei S, Block K, and Sudarshan S, L-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer, Cancer Discovery, Published On-Line, Published OnlineFirst September 2, 2014, doi: 10.1158/2159-8290.CD-13-0696.
  • Nijampatnam B, Nadkarni DH, Wu H and Velu SE, Antibacterial and Antibiofilm Activities of Makaluvamine Analogs, Microorganisms , 2014, 2, 128-139.
  • Nadkarni DH, Murugesan S and Velu SE, Total synthesis of zyzzyanones A-D, Tetrahedron, 2013, 69, 4105-4113.
Velu GroupWe are located in the Labs 137 and 143 on the first floor of Chemistry building which is located at 901, 14th street South on UAB campus by the side of UAB Green. The main focus of this lab is Drug Discovery and Development. Lab work force is mainly constituted of Graduate Students working towards their PhD degree, Undergraduate Students carrying out their Senior / Honors Research, Postdoctoral trainees and occasionally Research Assistants. The research projects are mainly directed towards the discovery of anti-cancer and anti-infective agents. There are also a few other drug discovery projects that we are currently working on. Ongoing research projects are listed below:
  • Discovery and Development of Anti-Breast Cancer Agents from Marine Alkaloids
  • Discovery of Inhibitors of Staphylococcus aureus Sortase A
  • Structure Based Design of inhibitors of Trypanosoma Cruzi Dihydrofolate Reductase
  • Voltage-Gated Sodium Channel Blockers for Preventing Cancer Metastasis
  • Synthesis of Novel Mitochondrially Targeted Antioxidant Therapeutics

The students who work on these projects will be trained broadly in the areas of Medicinal Chemistry and Organic Chemistry. More specifically, they will be trained in Organic Synthesis, Compound Purification, Compound Characterization, Spectroscopy (NMR. MS, IR, UV, Fluorescence), Structure Based and Fragment Based Drug discovery, Molecular Modeling, In-Silico Virtual Screening, Lead Identification, Structure Activity Relationship Studies, Lead Optimization, In Vitro Enzymatic Assays and Cell based Assays.
Velu and students

Graduate Students

shilpa dutta
Shilpa Dutta, MS
(Co-directed with Dr. Wayne Brouillette)
MS from Punjab University, Chandigarh, India
Lab: CHEM 143
Phone: (205) 996-4194
Project: Discovery of voltage gated sodium channel blockers

Sonia Nijampatnam
Sonia Nijampatnam, BS
BS from McMaster University, Canada
Lab: CHEM 137
Phone: (205) 996-4194
Project: Development of therapeutic agents for dental caries.

jeffrey mcdonald
Jeffrey McDonald, BS
The University of Tennessee at Chattanooga, TN
Lab: CHEM 143
Phone: (205) 996-4194
Project: Novel Exogenous Agonist Design for Caseinolytic Protease P

Undergraduate Students

luke casals
Luke Casals
Lab: CHEM 143
Phone: (205) 996-4194

rouwen zheng
Rouwen Zheng
Lab: CHEM 137
Phone: (205) 996-4194

jamie lin
Jamie Lin
Lab: CHEM 143
Phone: (205) 996-4194

john bradford
John Bradford
Lab: CHEM 143
Phone: (205) 996-4194

Former Graduate Students

Dwayaja H Nadkarni, PhD
Graduated in 2011
PhD Thesis: “Syntheses of Marine Natural Products and their analogs as potential anticancer agents”.
Current Position: Research Executive, Unichem LTD.

Bala Chandra Chenna, PhD
Graduated in 2013
PhD Thesis: “Identification of Staphylococcus Aureus Sortase A Inhibitors as Potential Antibacterial Agents”.
Current Position: Postdoctoral Research Associate, Texas A&M University.

Thao Nguyen, PhD
Graduated in 2014
PhD Thesis: “Design and syntheses of DHFR inhibitors as potential drugs against Trypanosoma cruzi And Streptococcus mutans
Current Position: Forensic Scientist, Alabama Department of Forensic Sciences.
Travis Hicks, MS
MS: Graduated, May 2011

Sam Tanner, MS
MS: Graduated, May 2010

Academic distinctions:
  • Award for Excellence in Teaching: In 2006, Dr. Velu’s undergraduate organic chemistry course was identified as an example of Best Practices in a National Study of Chemistry courses conducted by the Center for Educational Policy Research (CEPR) on behalf of the College Board.
Professional Societies:
  • Society Affiliations and Memberships
  • American Association of Cancer Research (AACR)
  • Society of Clinical and Translational Science (SCTS)
  • American Chemical Society (ACS)
  • American Heart Association (AHA)
UAB Affiliations and Co-appointments:
  • Associate Scientist, Comprehensive Cancer Center (CCC-UAB)
  • Faculty, Cystic Fibrosis Research Center (CFRC-UAB)
  • Faculty, Graduate Biomedical Sciences (GBS)
  • Member, Center for Biophysical Sciences and Engineering (CBSE-UAB)
  • Member, Center for Free Radical Biology (CFRB-UAB)
  • Member, Lung Health Center (LHL-UAB)