CCTS played a lead role in the implementation of the OnCore Enterprise clinical trials management system (CTMS) at UAB, our CTSA Hub. The OnCore CTMS replaced SiteMinder, which was officially retired at the end of September 2018.

The OnCore Team, which drew on the expertise of staff from the CCTS Clinical Research Support Program (CRSP), the Clinical Trials Administrative Office (CTAO), and the Hub’s Health System Information Services (HSIS), migrated 274 protocols and their associated patient records from SiteMinder to OnCore in three waves in late 2017-2018. CRSP trained more than 270 individual users on OnCore within the same period and provided leadership to several working groups focused on budgeting, financials, protocols, reporting and administration, and subject management.

The masterful launch of OnCore is the result of superb teamwork including months of painstaking effort migrating and validating study data, training super users, and supporting end users with a call center (for a complete list of the OnCore SuperUsers and Support Team, see “CCTS Thanks Its OnCore Support Team and SuperUsers”).

OnCore Benefits Patients, Clinicians, and Researchers

OnCore offers several advantages over SiteMinder including centralized protocol tracking from start-up to closeout, streamlined patient and billing processes, regulatory compliance support, and transmission of study and patient data to UAB’s electronic medical record. The integration of OnCore and PowerTrials offers improved capabilities in electronic ordering of clinical services as well as new recruitment and patient safety features.

Data Integration Empowers Research

OnCore sends protocol and patient information to the UAB electronic health record (Cerner’s IMPACT) through PowerTrials. When a new patient is registered to a clinical trial in OnCore, their medical record in IMPACT is associated with the protocol and an indicator that the patient is on a study is displayed in the banner bar of their chart. Clinicians are now able to click on this link to view study information and relevant contact information for the principal investigator and study coordinator for the trial in the Research Summary.

Research summaries contain key information that is useful at the point of care and for clinical care providers who are treating patients enrolled in clinical trials. More than 470 protocols and their associated patients have been sent from OnCore to Cerner, and order sets (aka PowerPlans) to support study implementation are continually being built.

Next Steps

Version 15, an OnCore upgrade, is coming soon and will bring new features and functionality, particularly in the financial area. Once again, CRSP will play a key role in the implementation. To learn more about OnCore development plans, visit the OnCore Updates page.  


  • “Without the OnCore training team working closely with us, we would not have been fully trained to begin utilizing OnCore’s subject module for the Alabama Genomic Health Initiative.”


    — Renie Moss, MA, Department of Genetics, UAB