The Importance of All of Us Research’s Health Database for the Future

The Importance of All of Us Research’s Health Database for the Future

The goal of the All of Us Research Program is to help researchers understand more about why people get sick or stay healthy. People who join will give information about their health, habits, and what it’s like where they live. By looking for patterns, researchers may learn more about what affects people’s health. UAB Informatics Institute Director, CCTS CoDirector, and All of Us CoInvestigator James J. Cimino, MD, discusses the role of informatics in the All of Us program.

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New Efforts to Control Opioids Become ‘Funhouse Mirror Image’ of Prior Policies

New Efforts to Control Opioids Become ‘Funhouse Mirror Image’ of Prior Policies

In a critical analysis of U.S. opioid policy published in Addiction, UAB Division of Preventive Medicine professor Stefan Kertesz, MD, MSc, and his co-author describe the swing in U.S. policies from encouragement of opioid prescribing to today’s increasingly rigid restrictions as simplistic responses to a complex human challenge.

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When We Eat, or Don’t Eat, May Be Critical for Health

When We Eat, or Don’t Eat, May Be Critical for Health

Nutrition scientists have long debated the best diet for optimal health. But now some experts believe that it’s not just what we eat that’s critical for good health, but when we eat it.

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Human Clinical Trial Reveals Verapamil as an Effective Type 1 Diabetes Therapy

Human Clinical Trial Reveals Verapamil as an Effective Type 1 Diabetes Therapy

UAB researchers have established verapamil as a successful therapeutic approach to target loss of beta cell function caused by Type 1 diabetes. The findings, published by Nature Medicine, reveal that regular oral administration of verapamil, a common blood pressure medication first approved for medical use in 1981, enabled patients to produce higher levels of their own insulin, limiting their need for insulin injections to balance out their blood sugar levels.

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Does Vaping Lead to Abuse of Illicit Substances? Rehab Scientists Use i2b2 to Find Answers

Does Vaping Lead to Abuse of Illicit Substances? Rehab Scientists Use i2b2 to Find Answers

With electronic-cigarette use on the rise, doctoral student Abdullah Alanazi and Eric Ford, Ph.D., professor in the School of Public Health, want to understand the trend's relationship with drug use —and is using UAB's informatics framework for translational research to do it.

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Commercialization of Breakthrough Medical Research Enhanced by National Entrepreneurship Program

Commercialization of Breakthrough Medical Research Enhanced by National Entrepreneurship Program

The University of Alabama at Birmingham Center for Clinical and Translational Science is leading the way in better preparing the nation’s biomedical scientists and engineers to extend their focus beyond the laboratory and broaden the impact of their science.

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Study Using i2b2 Could Help Standardize Use of Therapeutic Comas for Epileptic Patients

Study Using i2b2 Could Help Standardize Use of Therapeutic Comas for Epileptic Patients

There’s no evidence-based consensus on how long a seizure-ridden patient should be kept in an artificial coma to enable the brain to recover. Wolfgang Muhlhofer, M.D., an assistant professor of neurology, wants to change that.

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i2b2 Helps Answer Questions About Spina Bifida and Reproduction

i2b2 Helps Answer Questions About Spina Bifida and Reproduction

Children’s of Alabama is home to the largest pediatric spina-bifida multidisciplinary clinic in the state with more than 500 patients, and in 2012 UAB opened its own adult-transition clinic. Nurse Morgan Dew and other clinicians began to take note of a trend — many women born with spina bifida were leaving pediatric care not realizing they could become pregnant.

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Fouad Named Co-Chair for All of Us Science Committee

Fouad Named Co-Chair for All of Us Science Committee

Mona Fouad, MD, MPH, senior associate dean fo Diversity and Inclusion, has been named co-chair of the Science Committee for the All of Us Research Program. Fouad will share leadership duties with Jordan W. Smoller, MD, ScD, associate chief for research for the Mass General Department of Psychiatry.

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Locke wins ACTS Distinguished Investigator Award

Locke wins ACTS Distinguished Investigator Award

The Association for Clinical and Translational Science awarded Jayme Locke, MD, Director of UAB’s Incompatible Kidney Transplant Program, its Distinguished Investigator Award for her outstanding contributions. Locke, who directs UAB's Kidney Chain, the world’s longest at 94, develops innovative strategies for transplanting incompatible organs, increasing living donor participation and reducing disparities in transplant access and outcomes — even for HIV-positive patients.

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Research Discovers How Some Cancers Resist Treatment

Research Discovers How Some Cancers Resist Treatment

An international team of researchers led by CCTS Site Lead Lucio Miele, MD, PhD, Professor and Chair of Genetics and Director of the Precision Medicine Program at LSU Health New Orleans School of Medicine, has found new genetic mutations that promote the survival of cancer cells. Dr. Miele and his coauthor Dr. Justin Stebbing, Professor of Cancer Medicine and Medical Oncology at the Imperial College of Medicine in London, led an international team of researchers in testing genes in 44 cancers that no longer respond to therapy. They found the cancers had evolved new "driver" mutations that impart resistance. The mutations exist in functional pathways that can be targeted with existing drugs, enabling a precision medicine approach to treatment.

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UAB-led Study Shows Drug Effectiveness in Reducing Glucocorticoid-Induced Bone Loss

UAB-led Study Shows Drug Effectiveness in Reducing Glucocorticoid-Induced Bone Loss

About 1 in every 100 people in the world takes glucocorticoids long term to treat immune-mediated diseases. An alternative treatment option appears promising.

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Kimberly Named President for the Association for Clinical and Translational Science (ACTS)

Kimberly Named President for the Association for Clinical and Translational Science (ACTS)

Robert P. Kimberly, M.D., has been inducted as president for the Association for Clinical and Translational Science (ACTS), which is the field's preeminent national organization.

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Precision Medicine Unlocks the Answers Inside You

Precision Medicine Unlocks the Answers Inside You

UAB has leaped into a leading role in precision medicine, making the dream of truly individualized care a reality for Alabamians today. Follow along as we share some early successes and look ahead to exciting breakthroughs that could help you live your one-of-a-kind life to the fullest.

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Study Determines Cardiovascular Safety of Medication for Gout Patients

Study Determines Cardiovascular Safety of Medication for Gout Patients

In a collaborative study published by The New England Journal of Medicine, rheumatologists researched the relative cardiovascular safety of drugs used to manage gout, as there is a high association of cardiovascular disease in gout patients.

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HudsonAlpha Scientists Find Colon Polyp Marker that Could Lead to an End of Some Colonoscopies

HudsonAlpha Scientists Find Colon Polyp Marker that Could Lead to an End of Some Colonoscopies

HudsonAlpha Institute for Biotechnology researchers have discovered a measurable indicator in blood plasma that could identify patients who have colon polyps.

The finding is an important first step in developing a blood test to screen for colon polyps that could become cancerous or even for colon cancer. The study was published online last week in Clinical Cancer Research, a publication of the American Association for Cancer Research.

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Caffeine Found to Reduce Incidence of Acute Kidney Injury in Neonates

Caffeine Found to Reduce Incidence of Acute Kidney Injury in Neonates

Preterm neonates who are exposed to caffeine within the first seven days after birth have reduced incidence and severity of acute kidney injuries than neonates who did not, according to findings from the Neonatal Kidney Collaborative’s Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates study, published in JAMA Pediatrics. David Askenazi, MD, professor in the University of Alabama at Birmingham’s Department of Pediatrics and director of the UAB and Children’s of Alabama’s Pediatric and Infant Center for Acute Nephrology, was the study’s co-author, and is the chair of the Neonatal Kidney Collaborative.

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UAB Business Professor Honored as Leader in Promoting Community Engagement and Inclusive Innovation

UAB Business Professor Honored as Leader in Promoting Community Engagement and Inclusive Innovation

Anthony C. Hood, PhD, associate professor in the University of Alabama at Birmingham Collat School of Business, received Alabama Power’s 2018 Power of Leadership award. Hood was honored for his engagement with local leaders to expand access to opportunities, particularly those leading to careers and leadership in science, technology, engineering and mathematics, and entrepreneurship.

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Featured Discovery: New Drug Combination Therapy for Cystic Fibrosis Shows Promise

Featured Discovery: New Drug Combination Therapy for Cystic Fibrosis Shows Promise

Steven Rowe, M.D., the director of the Gregory Fleming James Cystic Fibrosis Center and a professor in the Division of Pulmonary, Allergy and Critical Medicine at UAB, is the first winner of the School of Medicine’s Featured Discovery, an initiative designed to celebrate important research from School of Medicine faculty members.

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Separate and Unequal Access Frames Discussion at CROI Panel on U.S. HIV Care Cascade

Separate and Unequal Access Frames Discussion at CROI Panel on U.S. HIV Care Cascade

Attendees of the Monday, March 5, panel at the Conference on Retroviruses and Opportunistic Infections (CROI) discussing the HIV care cascade were probably expecting your usual set of presentations on what we're getting right or wrong about testing, linkage to/retention in care, and viral suppression. Those elements were there. But what was also clear from every presenter (a group that includes both researchers and medical providers) was that the lack of Medicaid expansion in the South is creating worse racial disparities in the U.S.

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A Diet Strategy That Counts Time, Not Calories

A Diet Strategy That Counts Time, Not Calories

The Wall Street Journal (WSJ) recently featured the research of CCTS KL2 Scholar Dr. Courtney Peterson, assistant professor of Nutrition Sciences at CCTS Partner Institution Pennington Biomedical Research Center. The article, "A Diet Strategy that Counts Time, Not Calories," highlighted her pilot study findings indicating time-restricted feeding (TRF) improved blood pressure and the ability to process sugar in pre-diabetic men. TRF shows promise as a weight loss approach and diabetes prevention intervention. A WSJ subscription is required to view this article.

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OnCore Implemented within the Department of Medicine

OnCore Implemented within the Department of Medicine

UAB and UAB Medicine have begun the enterprise implementation of OnCore, a management system for clinical trials and study-related information. The system is being expanded across the School of Medicine in three waves, with the first wave focused on the Department of Medicine.

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The Business of Innovation: I-Corps Program Teaches Scientists and Engineers How to be Entrepreneurs

The Business of Innovation: I-Corps Program Teaches Scientists and Engineers How to be Entrepreneurs

With an estimated failure rate for business startups hovering anywhere from 50 to 90 percent, success requires plenty of inspiration, perspiration, and preparation. The latter is what UAB is hoping to bolster through a new relationship with Innovation Corps (I-Corps), a National Science Foundation (NSF)-sponsored program designed to help scientists and engineers take their research from the laboratory to the marketplace.

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Celebrating Mona Fouad's Election to the National Academy of Medicine

Celebrating Mona Fouad's Election to the National Academy of Medicine

In October 2017, Mona Fouad, M.D., MPH, Senior Associate Dean for Diversity and Inclusion, was elected as a member of the National Academy of Medicine. This exceptional honor, which is considered one of the highest in the fields of health and medicine, recognizes individuals who have demonstrated outstanding professional achievement and commitment to service. Only 70 national members and 10 international members are elected each year.

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Cimino Elected to AMIA Board of Directors

Cimino Elected to AMIA Board of Directors

James J. Cimino, MD, director of the UAB Informatics Institute and endowed professor in Informatics, has been elected to the board of directors of the American Medical Informatics Association.

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Banking on Data: UAB's Informatics Institute Works to Leverage the Power of Big Data

Banking on Data: UAB's Informatics Institute Works to Leverage the Power of Big Data

By 2020, medical knowledge is projected to double every 73 days, making one of the chief challenges of the “genomic era” picking out relevant information from a sea of data. This has helped bring informatics to the forefront in medicine.

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Aller Recognized for cryo-EM Research by NIH

Aller Recognized for cryo-EM Research by NIH

Stephen Aller, PhD, associate professor in the Department of Pharmacology and Toxicology, has been recently recognized for integrating leading-edge technology, “cryo-EM” into his research on membrane protein structure, by the National Institutes of Health (NIH) Director Francis Collins at the most recent senate Appropriations Subcommittee hearing discussing the FY18 NIH budget.

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UAB Establishes NSF Innovation Corps Site to Further Innovation and Commercialization

UAB Establishes NSF Innovation Corps Site to Further Innovation and Commercialization

The National Science Foundation has designated the University of Alabama at Birmingham as an Innovation Corps Site to strengthen local innovation and foster the engagement of student, staff, faculty and researcher teams in transitioning technology concepts into the marketplace.

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CCTS Specializes in Turning Ideas into Action

CCTS Specializes in Turning Ideas into Action

In 2006, Congress launched the Center for Translational Science Award (CTSA) program to help accelerate the rate at which research discoveries are transformed into practical applications.

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The Community Health Innovation Awards Have Fostered Innovation in Community Engagement; Looking to Do More

The Community Health Innovation Awards Have Fostered Innovation in Community Engagement; Looking to Do More

In the two years since the awards began, the University of Alabama at Birmingham Center for Clinical and Translational Science’s Community Health Innovation Award grantees have seen some major successes. Now several new organizations competing for this year’s grants are gearing up to present their final project proposals to a panel of judges in the hope of becoming the next CHIA success story.

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NIH Awards Nearly $34 Million to UAB Center for Clinical and Translational Science

NIH Awards Nearly $34 Million to UAB Center for Clinical and Translational Science

The National Institutes of Health has awarded the University of Alabama at Birmingham Center for Clinical and Translational Science $33.59 million over four years to continue the center’s programs advancing translational research.

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