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The study of the microbiome brings together the cutting-edge methodologies and expertise in genomics and bioinformatics to define the changes in the community of commensal, symbiotic, and pathogenic microorganisms in an organism (or organ or ecosystem) in response to certain environmental conditions.

This core is composed of a Gnotobiotic Unit and a Genetically-Engineered Mouse Unit. The purposes of the core are to generate and provide gnotobiotic and genetically engineered mice to research projects and to provide specialized breeding, marker-assisted genotyping, and histopathologic evaluation services for studies using these mice. The mouse unit provides a designer breeding service to develop unique mouse "reagents" for use in fundamental studies. It also provides consultation with investigators to develop and implement breeding strategies for the generation of unique genotypes.  Learn more>

This laboratory is able to perform standard fluorescent and next-generation sequencing, high and low throughput custom genotyping from 1 SNP to more than 5 million SNPs, whole genome linkage and association studies, targeted and whole genome gene expression, and targeted and whole genome assays.  Learn more>

CCTS Informatics serves as the resource center for efforts that provide the infrastructure to collect structured clinical data at the point of care; export it to a data warehouse that also contains genomic and other biological information; and use the data for clinical, translational and outcomes research from bench to bedside and back.  Learn more >

This resource provides investigators assistance with: 1) experimental design and planning, 2) sample collection and preparation, 3) sequencing of 16S ribosomal genes, 4) bioinformatic and statistical analysis of the sequence reads, 5) extending the analytical capabilities to provide full metagenomic sequencing of experimental samples, and 6) testing cause-effect hypotheses by utilizing the germ-free animal models.  Learn more >