Mary-Ann Bjornsti, PhD

The SUMO conjugation pathway as a therapeutic target for Myc-driven tumors

Michael Niederweis, PhD

Targeting siderophore secretion, an Achilles heel of Mycobacterium tuberculosis

Frances E. Lund, PhD

Treating B cell-derived neoplasms by targeting the ectoenzyme CD38: a regulator of the NAD metabolic pathway

Sunnie R. Thompson, PhD

Development of an anticancer therapeutic against ribosomoal protein S25

Anupam Agarwal, MD

Screening for novel modulators of heme oxygenase-1 expression in human disease

Anath Shalev, MD

TXNIP Inhibitors: A novel approach to diabetes therapy

Xu Feng, PhD (UAB, Department of Molecular & Cellular Pathology)

Identification of Anti-RANK Signaling Compounds via HTS of Cell-Based Assays for Preventing and Treating Cancer Bone Metastases

David Schneider, PhD (UAB, Department of Biochemistry and Molecular Genetics)

Developing a fully-reconstituted human RNA Polymerase I transcription assay for drug screening

Corinne Griguer, PhD (UAB, Department of Surgery)

Cytochrome c oxidase inhibitors: Novel therapeutic approach to prevent / reverse cancer chemoresistance

*Louise Hecker, PhD (UAB, Department of Medicine)

Identification of Small Molecule Inhibitors Targeting NOX4

Joanne Murphy-Ullrich, PhD (UAB, Department of Molecular & Cellular Pathology)

Development of small molecule antagonists for blockade of TSP1-dependent TGFbeta activation for treatment of multiple myeloma

Erik Roberson, MD, PhD (UAB, Department of Neurology)

Targeting the Tau–Fyn Interaction in Alzheimer’s Disease

*William Parker, PhD (Southern Research) and Jaideep Thottassery, PhD (Southern Research)

Novel DNA Demethylating Nucleosides: T-dCyd, 5F- T-dCyd and 5-Aza-T-dCyd

Stephen Aller, PhD (UAB, Department of Pharmacology & Toxicology)

In silico screening and structure-based drug design for inhibitors of a multi-drug resistance transporter

*John Chatham, PhD (UAB, Department of Medicine) and Richard Marchase, PhD (UAB, Department of Cell Biology)

Prevention of stress-induced cellular calcium overload by inhibition of STIM1 mediated calcium entry pathways: A new therapy for ischemic injury

*Olaf Kutsch, PhD (UAB, Department of Medicine)

Hit & run stimulation to reactivate latent HIV-1 infection

Robert van Waardenburg, PhD (UAB, Department of Pharmacology & Toxicology)

Identification of small molecule poisons of the DNA repair protein Tyrosyl-DNA Phosphodiesterase I (TDP1)

Talene Yacoubian, MD, PhD (UAB, Department of Neurology)

Screening for inducers of 14-3-3theta expression for treatment of Parkinson’s Disease

*W. Timothy Garvey, MD (UAB, Department of Nutrition Sciences) and Yuchang Fu, PhD (UAB, Department of Nutrition Sciences)

NR4A3 Orphan Nuclear Receptor as a Target for the Treatment of Insulin Resistance

*Krister Wennerberg, PhD (Southern Research Institute)

Discovery and Development of Ect2 Inhibitors as Anti-Cancer Drugs

*Andrew West, PhD (UAB, Department of Neurology)

Discovery of LRRK2 kinase inhibitors for treatment of Parkinson’s Disease

Sadanandan Velu, PhD (UAB, Department of Chemistry)

Novel Marine Alkaloid Analogs for Breast Cancer Therapy

Scott Blume, PhD (UAB, Department of Medicine; Division of Hematology & Oncology)

A Strategy to Specifically Modulate the Translation of Individual Cancer-Relevant Genes

Lawrence J. DeLucas, OD, PhD (UAB, Department of Optometry)

USP2a, a Deubiquitinating Protein Implicated in Prostate Cancer

*L. Burt Nabors, MD (UAB, Department of Neurology)

The Post-transcriptional Regulator, HuR, as a Novel Therapeutic Target in Malignant Glioma