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Rigor and Reproducibility in Research Additional External Resources
NIH – Rigor and Reproducibility Scientific rigor and transparency in conducting biomedical research is key to the successful application of knowledge toward improving health outcomes. The information provided on this website is designed to assist the extramural community in addressing rigor and transparency in NIH grant applications and progress reports.
- NIH Policy: Enhancing Reproducibility through Rigor and Transparency (NIH Presentation)
- NIH Website - Principles and Guidelines for Reporting Preclinical Research
- Your One Page Guide to Rigor and Reproducibility (NIH PDF)
- NIH Presentation - Rigor and Reproducibility: Back to Basics
- Implementing Rigor and Transparency Policies in Review--Lessons Learned
Cell Lines
- Lorsch JR, Collins FS, Lippincott-Schwartz J. Cell Biology. Fixing problems with cell lines. Science. 2014 Dec 19;346(6216):1452-3
- Database of Cross-contaminated or Misidentified Cell Lines
- Hundreds of researchers are using the wrong cells. That’s a major problem. By Amanda Capes-Davis, PhD, chair of the International Cell Line Authentication Committee (ICLAC)
Antibodies
- Improving Reproducibility: Best Practices for Antibodies - Sigma Aldrich Publications
Biologic Variables
- Clayton, JA. Studying Both Sexes: A Guiding Principle for Biomedicine. FASEB J. 2016 30:1-6
Statistical Methodology
- TBA
Historical Perspective – How did we get here?
- Collins FS, Tabak LA. Policy: NIH plans to enhance reproducibility. Nature. 2014 Jan 30;505(7485):612-3
- Nuzzo R. How scientists fool themselves - and how they can stop. Nature. 2015 Oct 8;526(7572):182-5
- Clayton JA, Collins FS. Policy: NIH to balance sex in cell and animal studies. Nature. 2014 May 15;509(7500):282-3