Research Commons
CCTS supports clinical and translational research across the Partner Network. The CCTS Research Commons domain connects investigators to the expertise and technology they need, including tools, institutional resources, expert consultation and collaborators. The goal? To sharpen science and accelerate the pace of discovery, thereby improving patient care and reducing disparities and diseases that disproportionately affect our region. Learn moreTraining Academy
CCTS seeks to develop a diverse and highly skilled clinical and translational research workforce well-prepared to collaborate, innovate, and accelerate the pace of scientific discoveries to improve patient care. Our Training Academy domain offers interdisciplinary, educational programs and enrichment activities for research teams across the career arc – faculty, trainees, staff and community members alike – to support a vibrant learning community with the skills, knowledge and perspective to effectively advance research insights to application. Learn moreClinical Translation
The CCTS supports cutting-edge expertise and facilities to investigators conducting human subjects research. Our Clinical Translation domain provides cost-effective, quality services that exemplify best practice for every stage of the clinical research study lifecycle, from startup through implementation to closeout. Learn moreEngagement of Communities
The CCTS supports the development of authentic partnerships between researchers and the populations we serve. Through our Engagement of Communities domain, we provide learning and collaboration opportunities to a wide variety of community stakeholders that foster trust, help establish shared research goals, and speed the translation of knowledge into health improvements for all. Learn moreSpecial Modules
Leveraging unique capacity across the CCTS Partner Network, the CCTS supports distinct research areas in genomic medicine, drug discovery, precision therapeutics and medical device development. This Special Modules domain reflects the CCTS commitment to innovative techniques and technologies that improve the quality, efficiency, and impact of translational research. Learn morePartner Network
The CCTS reaches across disciplines and across institutional boundaries locally, regionally and nationally to work synergistically with those who share our mission. Our 11-member Partner Network represents unprecedented translational research engagement drawing on complementary expertise, technical capacity and patient populations across the Deep South. We collaborate with a growing number of organizations in support of multisite studies aimed at catalyzing scientific discovery and accelerating those insights to impact health. Learn moreExternal Resources
Rigor and Reproducibility in Research Additional External Resources
NIH – Rigor and Reproducibility Scientific rigor and transparency in conducting biomedical research is key to the successful application of knowledge toward improving health outcomes. The information provided on this website is designed to assist the extramural community in addressing rigor and transparency in NIH grant applications and progress reports.
- NIH Policy: Enhancing Reproducibility through Rigor and Transparency (NIH Presentation)
- NIH Website - Principles and Guidelines for Reporting Preclinical Research
- Your One Page Guide to Rigor and Reproducibility (NIH PDF)
- NIH Presentation - Rigor and Reproducibility: Back to Basics
- Implementing Rigor and Transparency Policies in Review--Lessons Learned
Cell Lines
- Lorsch JR, Collins FS, Lippincott-Schwartz J. Cell Biology. Fixing problems with cell lines. Science. 2014 Dec 19;346(6216):1452-3
- Database of Cross-contaminated or Misidentified Cell Lines
- Hundreds of researchers are using the wrong cells. That’s a major problem. By Amanda Capes-Davis, PhD, chair of the International Cell Line Authentication Committee (ICLAC)
Antibodies
- Improving Reproducibility: Best Practices for Antibodies - Sigma Aldrich Publications
Biologic Variables
- Clayton, JA. Studying Both Sexes: A Guiding Principle for Biomedicine. FASEB J. 2016 30:1-6
Statistical Methodology
- TBA
Historical Perspective – How did we get here?
- Collins FS, Tabak LA. Policy: NIH plans to enhance reproducibility. Nature. 2014 Jan 30;505(7485):612-3
- Nuzzo R. How scientists fool themselves - and how they can stop. Nature. 2015 Oct 8;526(7572):182-5
- Clayton JA, Collins FS. Policy: NIH to balance sex in cell and animal studies. Nature. 2014 May 15;509(7500):282-3
- What are the problems? How can we fix them? What happens if we don’t? (American Physiological Society Presentations)