The mission of CNICS is to provide access to the specimen and data repository to any investigator who submits an approved concept proposal. In this fashion, CNICS is a 'peer-reviewed open access' research platform available to investigators world-wide. Currently, CNICS has the following approved concept studies ongoing or underway and completed.  Projects are identified in the listing by the approved CNICS study number, title of the study, lead investigator and institution. Once a study is approved, the PI has one year to submit a Data Request Form before the study data set is released and made available to other investigators for use. Contact us for more information on any of these projects or for questions about overlap.

001:  Impact of HAART and Metabolic Complications on Myocardial Infarction and Survival among HIV-infected Patients / Heidi Crane UW

002:  Incidence and Risk Factors for Triple Class Antiretroviral Regimen (ARV) Exposure and Failure in the CNICS Cohort / Richard Haubrich UCSD

003:  Biological and behavioral correlates of ART adherence and depression across diverse patients in the CNICS cohorts / Steven Safren Fenway

004:  The incidence and correlates of HIV superinfection before starting and after stopping antiretroviral therapy / Davey Smith UCSD

009:  Predictors of Severe Liver Enzyme Elevation and Immunologic Response to Initial HAART in Patients with HIV and Hepatitis Co-Infection / Chad Achenbach Northwestern

010:  Eligibility for Early Initiation of Highly Active Antiretroviral Therapy (HAART) to Decrease HIV Transmission / Julie Dombrowski UW

011:  Durability and Effectiveness of First-line ARV Regimens in treatment-naïve Patients Initiating Therapy in a Clinical Practice Setting / Michael Mugavero UAB

012:  Association of cellular immune function and phenotype with severe liver enzyme elevation (LEE) after Highly Active Antiretroviral Therapy (HAART) among HIV and viral hepatitis co-infected patients / Chad Achenbach Northwestern

013:  Long-term virologic outcomes of HIV-infected patients coinfected with hepatitis B on tenofovir-containing HAART / Nina Kim UW

014:  Prevalence and associations of unprotected sex and substance use in the CNICS cohort / Matthew Mimiaga Fenway

015:  Dynamic Assessment of Virologic Response and Mortality Among HIV-infected Patients Initiating Antiretroviral Therapy / Michael Mugavero UAB

016:  An Analysis of Renal Function Before and After the Initiation of Highly Antiretroviral Therapy (HAART) to Examine Correlates of Renal Function Preservation and Decline / Robert Kalayjian CWRU

017:  HIV Pathogenesis and Immunity in Viremic Non-Progressors / David Camerini UC Irvine

018:  The Predictors of HIV+ smokers and investigation of smoking recognition and intervention by providers in two HIV ambulatory clinics / Karen Cropsey UAB

019:  Molecular Epidemiology of HIV Transmission and Transmitted Resistance in Women and Minorities in the CNICS Cohort / Jeannette Aldous UCSD

020:  HIV infection in Sickle Cell Disease / Michael Lederman CWRU

022:  Comparison of plasma HIV RNA with CD4+ T cell count-based strategies for detection of first line treatment failure and initiation of regimen modification / Maya Peterson UC Berkeley

023:  Measuring HIV transmission risk among HIV+ patients at CNICS sites / Joseph Schumacher UAB

024:  AIDS-defining and non-AIDS defining malignancies among the CFAR Network of Integrated Clinical Systems (CNICS) / Michael Saag UAB

025:  Effects of Hepatitis B co-infection on HIV Antiretroviral Therapy Response and Long-term Outcomes / Sarah Radke UNC

027:   Methods to migrate from the 9-item Patient Health Questionnaire (PHQ-9) to computerized adaptive administration of the Patient Reported Outcomes Measurement Information System (PROMIS) depression measure / Heidi Crane UW

028:   HIV Infection and Response to Initial Therapy for Type 2 Diabetes / Jennifer Han UPENN

029:   Contribution of enzyme (protease) and substrate (gag) mutations to protease inhibitor resistance / David Looney UCSD

030:   Epidemiology & Outcomes of HIV-2 in the United States / Geoffrey Gottlieb UW

031:   Adherence to Clinical Care and Survival among HIV-infected Patients Initiating Antiretroviral Therapy / Michael Mugavero UAB

032:   HIV in the Elderly: Evaluating Indoleamine 2,3 dioxygenase as a marker for disease status / Stephanie Baer Medical College of GA

033:   HIV-associated Obstructive Pulmonary Disease Examinations (HOPE): Risk, Exacerbations, and Outcomes / Kristina Crothers UW STUDY CLOSED

034:   Prognosis of incidence and progression risk of AIDS-defining and non-AIDS-defining malignancies in HIV/AIDS patients / Julia Krauchanka Duke

035:   Body morphology abnormalities and patient reported outcomes:  depression, adherence, health-related quality of life, substance use, physical activity, and sexual risk behavior / Heidi Crane UW

036:   Routine Laboratory Monitoring During Virologically Suppressive Combination Antiretroviral Therapy in the US / Babafemi Taiwo Northwestern

037:   Fine mapping of MHC susceptibility loci for AIDS-related non-Hodgkin lymphoma / Brahim Aissani UAB

038:   The Timing of Antiretroviral Initiation among ART Naïve HIV Infected patients in routine clinical practice / Elvin Geng UCSF

039:   Cross-walk between commonly used measures of anxiety in patients with HIV and the Patient Reported Outcomes Measurement Information System (PROMIS) anxiety measure / Heidi Crane UW

040:   Determinants of Transmitted Drug Resistance (TDR) and Impact of “Test and Treat” Strategy on Transmission of Drug Resistance Among HIV-1 Infected Treatment-Naïve Patients: Influence of High Risk Behaviors as Determined by Patient Based Metrics (PBM) on TDR Prevalence and Modeled Probability of Transmission / Vi Bowman UCSD STUDY CLOSED

041:   Systematic Characterization of High-Risk HPV Infection in Head and Neck Carcinoma in HIV+ Individuals / Margaret Brandwein-Gensler UAB

042:   Durability of initial compared to subsequent HAART regimens / Eric Sahloff  U of Toledo

043:   Comparing Results from Two Methods for Estimating the Optimal CD4 Threshold for Initiating Antiretroviral Therapy / Bryan Shepherd Vanderbilt

044:   Biological Determinants of Long-term Immune Reconstitution following Combination Antiretroviral Therapy (cART) / Sharon Lewin Monash Univ-Australia

045:   BMI, Depression, and HIV Self-Care Behaviors among MSM /  Aaron Blashill Fenway

046:   Impact of presenting clinical features and subsequent treatment on outcomes after non-CNS HIV-associated lymphoma in the CNICS cohort / Satish Gopal UNC

047:  Time related factors of platelet count reduction in human immunodeficiency virus/HIV and Hepatitis C/HCV co-infected antiretroviral therapy/ARV Naiive patients / Chris Delaney Univ of FL

048:   Structural models for exposure effects in HIV progression cohorts / Steve Cole UNC

049:   Effects of Combination Antiretroviral Therapy on Risk of Non-AIDS-defining Cancers / Elizabeth Yanik UNC STUDY CLOSED

050:  The Causal Effect of Antidepressant Treatment on HIV Outcomes in the CNICS Multi-Site Observational Clinical Cohort: an Application of Marginal Structural Models / Brian Pence Duke

051: Risk factors and microRNA profiles of HIV associated lung cancer / Kristina Crothers & Lynn Schnapp   UW

052: Molecular epidemiology of HIV transmission networks between Rhode Island and Massachusetts / Phillip Chan  Brown University

053: Incidence and treatment of prostate cancer in HIV-infected men: do racial disparities exist? / Ramona Bhatia  Northwestern

055: Current practice of screening for incident HCV infection among HIV-infected individuals / Benjamin Linas   Boston Medical Center

056:  Evaluating the relationship between HIV transmission networks in the San Diego-Tijuana cross-Border HIV epidemic and the rest of the United States and the difference between geographically localized and geographically diverse transmission networks / Sanjay Mehta  UCSD

057: The Natural History of Malignancies Developing Among HIV Positive Individuals on Stable Antiretroviral Therapy / Anna Coghill  UW

058: Endothelial dysfunction, antiretroviral therapy, and non-AIDS defining events in the CNICS cohort / Susan Graham UW

059: When to switch cART: A comparison of switching strategies using observational data / Lauren Cain  Harvard

060: Effects of Hepatitis C Co-Infection in HIV Disease Progression and Long Term Outcomes / Jennifer Ling  UW

061: Frailty in HIV-Infected Older Adults / Charles Kamen and Supriya Mohile  U Rochester

062: STI Screening and determinants of infection among HIV-infected patients in primary care / Kenneth Mayer  Fenway

063: Diagnosis and treatment of depression in HIV/AIDS primary care: a comparative analysis of latino and non-latino white patients / Oscar Beltran  UTEP

064: Behavioral predictors of outcomes in HIV infected adolescents / Brian Zanoni Massachusetts General Hospital, Fenway Community Health

065: Optimal timing for starting cART in antiretroviral-naïve HIV-1–infected patients presenting with cryptococcal  meningitis / Jonathen Sterne University of Bristol

066: Plasma cell neoplasms in HIV infected people: a multi center case series / Eric Engels National Cancer Institute STUDY CLOSED

067: Molecular profiling of HIV-associated lymphoma occurring before and during antiretroviral therapy / Satish Gopal  UNC

068: Alcohol Research Consortium in HIV – Epidemiological Research Arm (ARCH-ERA) U01AA020793 / Heidi Crane UW

069: Comparative effectiveness of SSRIs and SGAs among patients aging with HIV / Heidi Crane UW

070:  OMCICH: Optimal Multidisciplinary Care in the Clinical HIV Setting / Michael Horberg Mid-Atlantic Kaiser Permanente Group

071: Factors that influence the response to Hepatitis A vaccine among HIV-infected individuals / Heidi Crane UW

072: Statins in HIV: Immune Reconstitution, Comorbid Events, and Survival / Dan Drozd UW

073: Epidemiology of Cerebrovascular Disease in CNICS/ David Tirschwell UW

074: Race-specific association between CCR5 -2459G>A genotype and virologic response to HAART in the CNICS cohort / Rajeev Mehlotra CWRU STUDY CLOSED

075: Modeling the dynamic association of BMI and mortality in HIV positive adults / Jianghua He (Wendy) UMASS STUDY CLOSED

076: Relationship of virologic suppression and control of cardiometabolic comorbidities in HIV-infected patients on antiretroviral therapy / Greer Burkholder UAB

077: Incidence and treatment of anal cancer in HIV-infected individuals: do racial/ethnic disparities exist? / Candice McNeil Stanford

078:  Hepatitis C treatment uptake and predictors of HCV therapy among HIV-infected individuals in the era of direct-acting antiviral agents /Ed Cachay UCSD

079:  Sero-incidence of Herpes Simplex Virus Types 1 and 2 in HIV-infected persons receiving HIV-care / Nicholas Van Wagoner UAB

080:  Circulating microRNAs in HIV-infected patients with and without coronary artery disease / Venkata Narla and Priscilla Hsue UCSF

081:  Understanding Patient Populations Receiving Antiretroviral Therapy: Observational Channeling Bias Study / Michael Saag, Steve Cole, Andy Westfall UAB

083:  Effectiveness of antiretroviral therapy (ART) with upfront chemotherapy versus ART along in HIV-infected patients with delayed vs normal immune recovery on suppressive ART / Jackie Wang UCSF STUDY CLOSED

084: Selection bias due to restriction in cohort studies / Chanelle Howe Brown University

085: Antiretroviral switches in HIV/HCV co-infected patients: initiating direct acting antiviral therapies for hepatitis C infection / Julius Wilder & Susanna Naggie Duke

086: HIV-related Health Disparities in Latinos Living with HIV in the United States / John Sauceda  UCSF

087: When to Monitor: A comparison of immunologic and virologic monitoring strategies using observational data / Ellen Caniglia Harvard

088: Differential Virologic and Resistance Outcomes when using Efavirenz-based Single Tablet Regimens versus Multiple Tablet Regimens in HIV Treatment / Michael Saag & Andy Westfall UAB

090: Identify and Manage Promptly Incident Hepatitis C: Testing to Treatment in HIV (IMPACT-C) / Benjamin Linas & Lynn Taylor Boston Medical Center STUDY CLOSED

091: Preventive fractions of Kaposi sarcoma and non-Hodgkin lymphoma in the modern ART era / Elizabeth Yanik NCI

092: Application of the Updated ACC/AHA Atherosclerotic CVD Risk Assessment Tool and Prevention Guidelines Among HIV-Infected Individuals: CFAR Network of Integrated Clinical Systems (CNICS) / Matthew Feinstein  Northwestern U

093: Analysis of CNICS data to inform design of interventions to enhance HIV care among substance abusers / Bryan Hartzler  UW

094: Population interventions on smoking in the CNICS / Daniel Westreich UNC

095: Factors Associated with HAART Mediciation Adherence among Older Adults Living with HIV in the U.S. / Brian Witt UNC-Charlotte

096: The Affordable Care Act, Socioeconomic Context, Spatial Mapping, and Outcomes Among People Living with HIV / Adaora Adimora UNC

097: Pathways contributing to racial and economic disparities among HIV clinic cohort patients / Chanelle Howe Brown University STUDY CLOSED

098: Genomic approaches to cardiometabolic risk and treatment in HIV / Inga Peter Mount Sinai

099: Investigating the relationship between chronic pain and HIV outcomes / Jessie Merlin UAB

100: Cardiovascular, pulmonary, and hematological disease in HIV: Prevention and Treatment / Heidi Crane UW

101: Statin use among HIV-infected patients / Greer Burkholder UAB

102: Comparative Effectiveness of Single-Action versus Multi-Action Antidepressants on Depression, Treatment Adherence and HIV Clinical Outcomes among People Living with HIV/AIDS and Depression / John Mills University of Florida

103: Development and Validation of a Multidimensional Index of Engagement in HIV Care / Mallory Johnson and Katerina Christopoulous UCSF

104: Calibration of a 1-Year Virologic Prediction Rule for Race/Ethnicity and Gender / Gregory Robbins Massachusetts General Hospital

105: The HIV Care Continuum: CD4 and Viral Load Measures as Proxies for Routine HIV Care Visits / Kimberly Powers UNC

106: Diminishing "Clinic Viral Load" in CNICS clinics in the U.S.: Socio-demographic and Therapeutic Correlations with Adherence / Jane Simoni UW

107: The CD4/CD8 ratio as a predictor of adverse outcomes in HIV-infected subjects under suppressive antiretroviral therapy and elite controllers / Sergio Serrano-Villar University Hospital Ramón y Cajal

108: Modeling Depression Treatment Strategies for Human Immunodeficiency Virus (HIV) Positive Patients / Rongbing Xie UAB

109: Physical activity patterns and metabolic disease outcomes in people living with HIV / Amanda Willig UAB

110: Projected Burden of Chronic Disease within the PLWH Population / Julia Hood UW

111: Impact of low-level HIV viremia on cancer risk / Jennifer Lee UNC

112: A statistical framework for integrated analysis of the HIV care cascade using CNICS data / Hana Lee Brown University

114: Self-management and quality of life in persons with HIV and diabetes, a comparision study / Julie Zungia University of Texas Austin

115: Lipidomic Profiling in HIV patients newly initiating antiretroviral treatment / Ryan Irvin UAB

116: Identification of Novel Metabolic Biomarkers for Predicting Cardiovascular Events in Persons Living with HIV / Svati Shah Duke University

117: Supplement to Approved CP 103: Development and Validation of a Multidimensional Index of Engagement in HIV Care / Mallory Johnson and Katerina Christopoulous UCSF

118: Efavirenz and the risk of suicidality / Angela Bengtson UNC

119: Age and Risk of HAART-Associated Nephrotoxicity: a Retrospective Cohort Study / Jessie Torgersen UPenn

120: Pathways contributing to racial/ethnic disparities among HIV clinic cohort patients / Chanelle Howe Brown University

122: At-Risk Alcohol Use and the Completion of Patient Reported Outcomes / Jacqueline Rudolph UNC

123: Examining causes of death among patients with HIV in the United States: methodologic tools and applicatons / Jess Edwards UNC

124: HIV and Behavioral Health Outcomes by Transgender Status: Findings from a Matched-Pair Substudy of the CFAR Network of Integrated Clinical Systems (CNICS) Cohort / Sari Reisner Fenway

125: Durability of Contemporary Antiretroviral Regimens in Treatment Naïve Persons living with HIV /  Ellen Eaton UAB

127: Comorbid Disease Development in HIV-infected Living Kidney Donor Candidates / Jayme Locke UAB

128: The Syndemics of Aging with HIV / Maile Karris UCSD

129: Hemoglobin as a criterion to switch antiretroviral therapy in HIV-positive individuals / Lauren Cain Harvard

130: Comparative effectiveness of integrase-inhibitor-based regimens versus NNTRI- and boosted-PI-based regimens / Steve Cole UNC

131: Patient-reported sexual risk behavior and viral suppression over time / Julia Raifman JHU

132: Comparing Duraility, Treatment Failure and Emergence of Resistance on Integrase Stand Transfer Inhibitor Treatment Regimens Among Treatment-Naive and Treatment-Experienced Patients with HIV / Viiv Healthcare, RTI Health Solutions

133: A Feasibility and Pilot Study of Clinical Outcomes among Transgender Women Living with HIV / Tonia Poteat JHU

135: The Joint Effects and Plausible Interventions for ART and Statin Use on Mortality / Jonathan Todd UNC STUDY CLOSED

136: Multi-level Social and Behavioral Determinants of Health and Missed HIV Healthcare Provider Visits / April Pettit Vanderbilt

137: Physical Activity and Symptom Distress in HIV+ Adults in the CNICS Database / Allison Webel Case Western

138: Statin use to prevent progression of liver disease among HIV infected individuals / Bryan Lau Johns Hopkins University

139: Real World Effectiveness of Direct-Acting Antiviral Agents for Hepatitis C Infection Among HIV/HCV-Coinfected Patients / Nina Kim UW

140: Cigarette Smoking and HIV Treatment Outcomes Among MSM  in Primary Care / Conall O'Cleirigh Harvard

141: Epidemiology of Heavily Treatment-Experienced (HTE) HIV Patients in the US / Ellen Eaton UAB

142: Development and Validation of Risk Prediction Model for End Stage Liver Disease and Hepatocellular Carcinoma in Persons living with HIV / Nina Kim UW

143: Evaluation of the efficacy, mechanism, and cost-effectiveness of Skills TO Manage Pain (STOMP), a novel group and peer-based behavioral intervention for chronic pain tailored to people living with HIV / Jessie Merlin UAB

144: Rates and Predictors of Bacterial STI in Women with HIV / Jodie Dionne-Odom UAB

145: Diabetes as a risk factor for tuberculosis in HIV positive individuals in the United States / Kristina Bajema UW

146: A personalized approach to mental health in HIV / A. Todd Fojo Johns Hopkins University

147: Epidemiology of HIV-related atrial fibrillation and associations with substance abuse / Susan Heckbert UW

148: Estimating the potential pool of HIV-infected deceased organ donors in the United States / Jayme Locke UAB

150: Patterns and Perceptions of e-Cigarettes and Vaporized Nicotine Among People Living with HIV / Rob Fredericksen UW

151: Longitudinal HIV Care Trajectories and HIV Transmission Risk from the Time of HIV Care Entry in the CNICS /  Kimberly Powers UNC

152: Condom-less sex behavior and health outcomes among HIV-infected patients in the PrEP era / Rob Fredericksen UW

153: Patient Usability and Acceptability of Electronic Patient-Reported Outcome Measures for Use in HIV Care / Rob Fredericksen UW

154: Plasma IL-6 signaling biomarkers and cardiovascular disease in the CNICS cohort / Sulggi Lee UCSF

155: HIV/HCV Coinfection and Incidence of Extrahepatic Cancers / Julia Marcus Harvard

156: Predictive Analytics for Retention in HIV Care / Jessica Ridgway University of Chicago

157: Understanding the effect of physical activity and dietary intake on the longitudinal symptom experience of HIV+ adults in the CNICS cohort / Amanda Willig UAB and Allison Webel CWRU

158: Preparing for Long-Acting Injectable ART: Patient and Provider Perceptions, Preferences, and Shared Decision-Making / David Wohl UNC

159: Health Outcomes among Patients in HIV Care Reporting Intimate Partner Violence / Rob Fredericksen UW

160: Impact and Correlates of Sub-Optimal Social Support Among Patients in HIV Care / Rob Fredericksen UW

162: Viral suppression and sexual risk among people living with HIV: potential impact of risk compensation on HIV transmission / Heather Pines UCSD

163: Improving Kidney Health for African Americans with HIV through Optimal Antiretroviral Therapy Selection / Ellen Eaton UAB

164: Role of medication assisted treatment on HIV treatment outcomes among opioid and stimulant users / Javier Cepeda UCSD

165: Effectiveness of second-line antiretroviral therapy / Thibaut Davy-Mendez UNC

166: Genes, substance use, and HIV outcomes in people living with HIV across the US / Heidi Crane UW

167: Interventions to prevent cardiovascular disease among people living with HIV / Alexander Breskin UNC

168: Characterization of Symptom Clusters Among People Living With HIV Disease / Natalie Wilson UCSF

169: Effectiveness of a smoking cessation algorithm integrated into HIV primary care / Karen Cropsey UAB

170: Determinants and Outcomes of Nicotine Metabolism in HIV / Robert Gross UPenn

171: Marijuana policy change impact on patterns of marijuana and other harmful substance use among people living with HIV: a mixed methods evaluation / Andrew Hahn UW

172: Prevalence and Risk Factors for Hepatitis Delta Infection Among a Cohort of HIV/Hepatitis B-Coinfected Patients in the United States / Vincent Lo Re / UW

173: Optimizing the Implementation of the U=U Strategy for HIV Prevention in Clinic Settings / Curt Beckwith Brown University

174: Substance use and risk of stroke among people living with HIV / Thomas Martin UCSD

175: Host genetics and risk of anal cancer among patients living with HIV / Helen Stankiewicz Karita UW

176: Genetic predictors of adiposity-related traits including body mass index, lipoatrophy, lipohypertrophy and ART treatment-induced obesity among people living with HIV / Sara Lindstreom UW

177: Gender Identity and Participation in Biomedical Research / April Pettit Vandervbilt

178: Differences in substance use patterns among people living with HIV by geographic region / Heidi Crane UW