""

Professor This email address is being protected from spambots. You need JavaScript enabled to view it.
Volker G094N
(205) 934-6690

Research and Teaching Interests: Stem cell biology, Cardiovascular regeneration, Genetic and epigenetic, Extracellular vesicles and exosomes, Glucose and lipid metabolism

Office Hours: By appointment

Education:

  • M.D., M.S., Tongji Medical University, China
  • Post-Doc, International Centre for Genetic Engineering & Biotechnology (ICGEB), Trieste, Italy. Molecular Biology & Genetics
  • Post-Doc, University of Illinois at Chicago, IL, Stem Cell Biology & Gene Therapy

Gangjian Qin, MD, FAHA, is Professor of Medicine and Biomedical Engineering. His research program is dedicated to defining the molecular mechanisms that underlie cardiovascular biology and contribute to the recovery from cardiovascular disease, and to translating the results from these basic science investigations to clinical applications. A portion of his research focuses on the transcriptional networks and genetic pathways that control the growth and function of blood vessels; his lab revealed the roles of the E2F cell cycle regulators in the ischemic angiogenesis and blood pressure regulation. Another focus of Dr. Qin’s research is to improve the reparative capacity of stem cells and extracellular vesicles (including exosomes) for ischemic heart disease; his work contributed to the field by disclosing novel molecular interactions between bone marrow stem cells and their microenvironment, establishing the significance of specific mobilization of stem cells in the ischemic tissue repair, uncovering the pivotal role of oxidative metabolism in vascular differentiation, and more recently, revealing a previously unrecognized role of cardiac exosomes (and their cargo microRNAs) in the systemic reparative responses. Dr. Qin has published over 110 original research articles in major international journals as well as numerous reviews, book chapters, and editorials. Over the last 18 years, Dr. Qin have trained or is training 50 research trainees at different academic levels.

Research Interests

Current research projects in Dr. Qin lab are focused on three areas:
  • Extracellular vesicles and exosomes in cardiovascular biology and disease
  • Metabolic regulation of cardiac hypertrophy and heart failure
  • Hepatic regulation of glucose and lipid metabolisms

Select Publications

  • Tang Y.L., Zhu W., Cheng M., Chen L., Zhang J., Sun T., Kishore R., Phillips M.I., Losordo D.W., and Qin G. Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression. Circ Res, 2009. 104:1209-16
  • Zhou J., Zhu Y., Cheng M., Dinesh D., Thorne T., Poh K.K., Liu D., Botros C., Tang Y.L., Reisdorph N., Kishore R., Losordo D.W., and Qin G. Regulation of vascular contractility and blood pressure by the E2F2 transcription factor. Circulation, 2009. 120:1213-21.
  • Cheng M., Zhou J., Wu M., Boriboun C., Thorne T., Liu T., Xiang Z., Zeng Q., Tanaka T., Tang Y.L., Kishore R., Tomasson M.H., Miller R.J., Losordo D.W., and Qin G. CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity. Circ Res, 2010. 107:1083-93.
  • Sahoo S., Klyachko E., Thorne T., Misener S., Shinnick K., Millay M., Ito A., Liu T., Kamide C., Agarwal H., Perlman H., Qin G., Kishore R., Losordo D.W. Exosomes from Human CD34+ Stem Cells Mediate Their Proangiogenic Paracrine Activity. Circ Res, 2011. 109:724-8
  • Zhou J., Cheng M., Wu M., Boriboun C., Jujo K., Xu S., Zhou T.C., Tang Y.L., Kishore R., and Qin G. Contrasting roles of E2F2 and E2F3 in endothelial cell growth and ischemic angiogenesis J Mol Cell Cardiol 2013. 60:68-71
  • Wu M., Zhou J., Cheng M., Boriboun C., Biyashev D., Wang H., Mackie A., Thorne T., Cho J., Wu Y., Chen Z., Yan H., Kishore R., Taylor R.N., Losordo D.W., Qin G. E2F1 Suppresses Cardiac Neovascularization by Downregulating VEGF and PlGF Expression. Cardiovasc Res, 2014. 104:412-22.
  • Zhou J., Cheng M., Boriboun C., Ardehali M.M., Jiang C., Liu Q., Han S., Goukassian D.A., Tang Y.L., Zhao T., Zhao M., Cai L., Richard S., Kishore R., Qin G. Inhibition of Sam68 triggers adipose tissue browning. J Endocrinol 2015. 225:181-9
  • Cheng M., Huang K., Zhou J., Tang Y-L., Zhao T.C., Miller R.J., Kishore R., Losordo D.W., and Qin G. A Critical Role of Src Family Kinase in SDF-1/CXCR4-Mediated Bone-Marrow Progenitor Cell Recruitment to the Ischemic Heart. J Mol Cell Cardiol 2015. 81:49-53)
  • Arnone B, Chen JY, Qin G. Characterization and analysis of long noncoding rna (lncRNA) in In Vitro- and Ex Vivoderived cardiac progenitor cells. PLoS ONE 2017. 12: e0180096 PMID: 28640894 PMCID: PMC5481004
  • Xu S, Tao J, Yang L, Zhang E, Boriboun C, Zhou J, Sun T, Cheng M, Huang K, Dong N-G, Liu Q, Zhao TC, Qiu H, Harris RA, Chandel NS, Losordo DW, Qin G. E2F1 suppresses oxidative metabolism and endothelial differentiation of bone marrow progenitor cells. Circ Res 2018. 122:701-11 PMID: 29358228 PMCID: PMC6021021
  • Cheng M, Yang J, Zhao X, Zhang E, Zeng Q, Yu Y, Yang L, Wu B, Yi G, Mao X, Huang K, Dong N, Xie M, Limdi NA, Prabhu SD, Zhang J, and Qin G Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells. Nat Comm 2019. 10:959 doi: 10.1038/s41467-019-08895-7. PMID: 30814518. PMCID: PMC6393447
  • Han S*, Xu Shiyue*, Zhou J, Qiao A, Boriboun C, Ma W, Li H, Diyashev D, Yang L, Zhang E, Liu Q, Jiang S, Zhao TC, Krishnamurthy P, Zhang C, Richard S, Qiu H, Zhang J, and Qin G. Sam68 impedes the recovery of arterial injury by augmenting inflammatory response. J Mol Cell Cardiol 2019. 137:82-92. PMID: 31639388 PMCID: PMC6889069
  • Han D, Yang J, Zhang E, Liu Y, Boriboun C, Qiao A, Yu Y, Sun J, Xu S, Yang L, Yan W, Luo B, Lu D, Zhang C, Jie C, Mobley J, Zhang J, Qin G. Analysis of mesenchymal stem cell proteome in situ in the infarcted heart. Theranostics 2020. 10:11324-38. doi: 10.7150/thno.47893

Academic Distinctions and Professional Societies

  • Fellow, the American Heart Association (FAHA)