Gangjian Qin

Vice Chair of Research; Professor This email address is being protected from spambots. You need JavaScript enabled to view it.
Volker G094N
(205) 934-6690

Research and Teaching Interests: Cardiovascular and stem cell biology, Angiogenesis, Genetic and epigenetic regulation of cardiovascular function

Office Hours: By appointment

Education:

  • M.D., Tongji Medical University, China

Gangjian Qin, MD, FAHA, is Professor of Medicine and Biomedical Engineering and the director of the UAB Molecular Cardiology Program. He has recently moved from the Feinberg Cardiovascular Research Institute, Northwestern University, where he served for nine years as assistant and tenured associate professor. A portion of his research focuses on the transcriptional networks and genetic pathways that control the growth and function of blood vessels. His lab for the first time described the roles of the E2F oncogenes in the ischemic angiogenesis and blood pressure regulation. Another focus of Dr. Qin’s research is to improve the reparative capacity of endogenous stem cells, including bone marrow stem cells and cardiac stem cells, for the treatment of ischemic heart disease. His work has contributed to the advancement of the field by characterizing the molecular interactions between bone marrow stem cells and their microenvironment and by establishing the significance of specific mobilization of stem cells in the ischemic tissue repair.

Most recently, his group has revealed a pivotal role of oxidative metabolism in stem cell differentiation into vascular endothelial cells. Additionally, Dr. Qin’s lab has identified a unique population of cardiac stem cells in the rodent heart and systemically evaluated the impact of ischemia/hypoxia on their regenerative capacity. Other ongoing research in Qin lab includes epigenetic mechanisms of cardiac differentiation of embryonic and induced-pluripotent stem (ES and iPS) cells, development of peptide-based nanoparticles for enhancing the therapeutic benefit of human progenitor cells in pre-clinical models, and novel signaling pathways linking adipose thermogenesis and obesity.

Dr. Qin has published over 90 original research articles in major international journals as well as numerous reviews, book chapters, and editorials. He serves on the editorial boards of a dozen international journals in the fields of stem cell biology and cardiovascular sciences and as a reviewer for over 40 biomedical journals. Dr. Qin’s research is supported by NIH, AHA, and the American Diabetes Association (ADA).

Download Curriculum Vitae (PDF)

Select Publications

  • Tang Y.L., Zhu W., Cheng M., Chen L., Zhang J., Sun T., Kishore R., Phillips M.I., Losordo D.W., and Qin G. Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression. Circ Res, 2009. 104:1209-16 (Editorial commended)
  • Zhou J., Zhu Y., Cheng M., Dinesh D., Thorne T., Poh K.K., Liu D., Botros C., Tang Y.L., Reisdorph N., Kishore R., Losordo D.W., and Qin G. Regulation of vascular contractility and blood pressure by the E2F2 transcription factor. Circulation, 2009. 120:1213-21. (Circulation Editors pick)
  • Cheng M., Zhou J., Wu M., Boriboun C., Thorne T., Liu T., Xiang Z., Zeng Q., Tanaka T., Tang Y.L., Kishore R., Tomasson M.H., Miller R.J., Losordo D.W., and Qin G. CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity. Circ Res, 2010. 107:1083-93. (Cover featured; Editors pick)
  • Sahoo S., Klyachko E., Thorne T., Misener S., Shinnick K., Millay M., Ito A., Liu T., Kamide C., Agarwal H., Perlman H., Qin G., Kishore R., Losordo D.W. Exosomes from Human CD34+ Stem Cells Mediate Their Proangiogenic Paracrine Activity. Cir Res, 2011. 109:724-8
  • Zhou J., Cheng M., Liao Y., Hu Y., Wu M., Wang Q., Qin B., Hong W., Zhu Y., Gao Y.M., Goukassian D., Zhao T.C., Tang Y.L., Raj Kishore, Qin G. Rosuvastatin enhances angiogenesis via eNOS–dependent mobilization of endothelial progenitor cells PLoS ONE 2013;8:e63126:1-7
  • Zhou J., Cheng M., Wu M., Boriboun C., Jujo K., Xu S., Zhou T.C., Tang Y.L., Kishore R., and Qin G. Contrasting roles of E2F2 and E2F3 in endothelial cell growth and ischemic angiogenesis J Mol Cell Cardiol 2013;60:68-71
  • Wu M., Zhou J., Cheng M., Boriboun C., Biyashev D., Wang H., Mackie A., Thorne T., Cho J., Wu Y., Chen Z., Yan H., Kishore R., Taylor R.N., Losordo D.W., Qin G. E2F1 Suppresses Cardiac Neovascularization by Downregulating VEGF and PlGF Expression. Cardiovasc Res Oct 23, 2014; 104:412-22.
  • Zhou J., Cheng M., Boriboun C., Ardehali M.M., Jiang C., Liu Q., Han S., Goukassian D.A., Tang Y.L., Zhao T., Zhao M., Cai L., Richard S., Kishore R., Qin G. Inhibition of Sam68 triggers adipose tissue browning. J Endocrinol 2015; 225:181-9
  • Cheng M., Huang K., Zhou J., Tang Y-L., Zhao T.C., Miller R.J., Kishore R., Losordo D.W., and Qin G. A Critical Role of Src Family Kinase in SDF-1/CXCR4-Mediated Bone-Marrow Progenitor Cell Recruitment to the Ischemic Heart. J Mol Cell Cardiol 2015; 81:49-53
  • Swartz K.L., Wood S.N., Murthy T., Ramirez O., Qin G., Pillai M.M., Rao S., Minella A.C.. E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts. Mol Cell Biol. 2016 Dec 19;37(1). pii: e00274-16.

Academic Distinctions and Professional Societies

  • Fellow, the American Heart Association (FAHA)
  • Lecture professor, Tianjin University of Traditional Chinese Medicine