Joel Berry.

Associate Professor; This email address is being protected from spambots. You need JavaScript enabled to view it.
Shelby 802
(205) 996-9661

Research and Teaching Interests: Bioinstrumentation, Biotransport, Bioimaging, Clinical innovations

Office Hours: By appointment

Education:

  • B.S., UAB, Biology
  • B.S., UAB, Mechanical Engineering
  • M.S. UAB, Mechanical Engineering UAB
  • Ph.D., Wake Forest University, Biomedical Engineering (Vascular Biomechanics)

Joel Berry, Ph.D. was born in Atlanta, Georgia, and received his Doctorate in Biomedical Engineering from Wake Forest University in Winston-Salem, North Carolina, where he studied cardiovascular fluid mechanics, medical imaging, and tissue engineering. He has been an associate professor of biomedical engineering at UAB since 2010. His early research focused on modeling the fluid and solid mechanical effects of metallic stents placed in arteries as well as the fluid mechanical effects of vascular cell development in engineered arteries. His current research centers on development of a three-dimensional tissue engineered model system for breast cancer that could be used to culture individual cancer cells from patients and permit testing of a panel of chemotherapeutics for drug development.

Dr. Berry is director of the undergraduate program in Biomedical Engineering at UAB and teaches undergraduate level bioinstrumentation and an undergraduate course pairing biomedical engineering students with physicians to innovate solutions to unsolved clinical problems. He is the associate director of the UAB Science and Technology Honors Program.

Recent Courses

  • BME 313: Bioinstrumentation
  • STH 299: Clinical Innovation
  • STH 201: Research methods in engineering

Research Interests

Dr. Berry’s major interests lie in two areas: cardiovascular biomechanics and tissue engineering. His research has focused largely on modeling the fluid and solid mechanical effects of metallic stents placed into normal and diseased arteries. His group has published more than 10 papers on this subject, received four patents for metallic stent designs, and created a startup company around two of the patents. In addition to theoretical and experimental in vitro modeling of stents, he has designed and conducted several pre-clinical studies in swine and primate peripheral arteries, the outcome of which have demonstrated that the stent structure has a profound influence on the arterial response.

It is from this base of knowledge and experience that his research has led to the concept of perfused, cell-seeded, prevascularized scaffolds for developing therapies for breast cancer. Dr. Berry has developed a technique for prevascularizing scaffold materials with 250 micron channels and shown that these channels also support a layer of endothelial cells under pulsatile flow conditions. This work is aimed at resolving some important limitations that currently exist 2D in vitro and in vivo animal studies that are current paradigm in anti-cancer drug development.

Select Publications

  • Fee TJ, Dean DR, Eberhardt AE, Berry, JL. A Novel Device to Quantify the Mechanical Properties of Electrospun Nanofibers. J Biomech Eng. 134(10), 2012.
  • Sorace AG, Robbin ML, Umphrey H, Abts CA, Berry JL, Lockhart ME, Allon M, Hoyt K. Ultrasound Measurement of Brachial Artery Elasticity Prior to Hemodialysis Access Placement- A Pilot Study. J Ultrasound Med. 31(10):1581-8, 2012.
  • Kuppler CS, Christie JW, Newton WB 3rd, Ghanami RJ, Craven TE, Berry JL, Hansen KJ.J Surg Res. 183(1):457-61, 2013.
  • Rolland PH, Guillaume L, Velly L, Vidal V, Mayakonda V, Carroll DL, Berry JL. A Nanoengineered Embolic Agent for Precise Radiofrequency Ablation. Annals of Biomedical Engineering 42(5):940–949, 2014.
  • Andukuri A, Min I, Hwang P, Alexander G, Marshall LE, Berry JL, Wick TM, Joung YK, Yoon Y-S, Brott BC, Han DK, and Jun H-W. Evaluation of the effect of expansion and shear stress on a self-assembled endothelium mimicking nanomatrix coating for drug eluting stents in vitro and in vivo. Biofabrication Sep;6(3):035019.
  • Marshall LE, Goliwas K, Miller L, Penman AD, Frost A, Berry JL. Flow-Perfusion Bioreactor System Enables Endothelialization of Three-Dimensional Collagen Hydrogels. Tissue Engineering and Regenerative Medicine (Accepted J Tissue Eng Regen Med, 2015).
  • Goliwas KF, Marshall LE, Ransaw EL, Berry JL, Frost AR. A recapitulative three-dimensional model of breast carcinoma requires perfusion for multi-week growth. Journal of tissue engineering. 2016;7:2041731416660739. PMID: 27516850 PMCID: PMC4968110.
  • Goliwas KF, Miller LM, Marshall LE, Berry JL, Frost AR. Preparation and Analysis of In Vitro Three Dimensional Breast Carcinoma Surrogates. Journal of visualized experiments : JoVE. 2016; (111).PMID: 27214165.
  • Borovjagin AV, Ogle BM, Berry JL, Zhang J. From Microscale Devices to 3D Printing: Advances in Fabrication of 3D Cardiovascular Tissues. Circ Res. 2017 Jan 6;120(1):150-165. PMID: 28057791.

Academic Distinctions and Professional Societies

  • Biomedical Engineering Society
  • NIH Cardiovascular Sciences Special Emphasis Panel, 2004
  • NIH SBIR Cardiovascular Review Panel, 2005
  • NIH Special Emphasis Panel/Scientific Review Group 2005/10 ZRG1 CVS-F (91) (S)
  • Cardiovascular Dynamics, 2005
  • Heart Valve Bioreactor Museum Exhibit, 2009-present, Chicago Museum of Science and Industry, YOU Exhibit
  • American Heart Association Bioengineering Study Section 2016-2017

Student Groups