Ramaswamy Kannappan

Assistant Professor This email address is being protected from spambots. You need JavaScript enabled to view it.
Volker G094S
(205) 996-0826

Research and Teaching Interests: Cardiovascular and stem cell biology, Cardiac tissue engineering, Molecular and biochemical regulation of cardiac regeneration and function

Office Hours: By appointment

Education:

  • B.Pharm, Tamil Nadu Dr. M.G.R. Medical University, India
  • M.Pharm, Tamil Nadu Dr. M.G.R. Medical University, India, Pharmaceutical Biotechnology
  • Ph.D., Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan, Pharmaceutical Sciences

I was born in Madurai, a small city located in the southern part of India, and received my doctorate in Pharmaceutical Sciences from Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan. I then moved to USA for postdoctoral training. My research in the Department of Biomedical Engineering is focused on cardiac regeneration using induced pluripotent stem cells, and I teach induced pluripotent stem cell technology to master's and Ph.D. students. Currently I am developing a technology for selecting phenotypically young cells capable of stress resistance to use in the cardiac stem cell therapy. I am the editor-in-chief of BME department's quarterly eNewsletter and serve as the co-chair of the BME Visibility and Recognition committee.

I have an extensive experience and knowledge in cardiac regeneration, cellular therapy, aging and stem cell biology and in vivo small animal cardiac models. In the course of my career I have acquired a broad technical skill in the areas of biochemistry, molecular biology, cell signaling and in vivo techniques. Recently, by genetic manipulation of the transcription factor p53, a major regulator of cell viability, I have devised a method to segregate phenotypically younger cells from a pool of distinctive population of stem cells. Presently I am establishing approaches to transfer the above genetic strategy to larger animal models and humans to increase cell engraftment proliferation with cell therapy for the failing heart. I am also interested in understanding the role of hemodynamics mediated signaling that influences differentiation and maturation of iPS cell derived cardiomyocytes. My interests are maternal diabetes-induced congenital heart failure and high throughput drug screening using iPS-CM disease models.

Select Publications

  • Kannappan R, Matsuda A, Ferreira-Martins J, Zhang E, Palano G, Czarna A, Cabral-Da-Silva MC, Bastos-Carvalho A, Sanada F, Ide N, Rota M, Blasco MA, Serrano M, Anversa P, Leri A. p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo. EBioMedicine. 2017 Feb;16:224-237. PMID: 28163043.
  • Kannappan R, Zhang J. Meeting Report for NIH 2016 Progenitor Cell Biology Consortium Cardiovascular Tissue Engineering 2016. Circ Res. 2016 Oct 14;119(9):981-983. PMID: 27737941.
  • Meo M, Meste O, Signore S, Sorrentino A, Cannata A, Zhou Y, Matsuda A, Luciani M, Kannappan R, Goichberg P, Leri A, Anversa P, Rota M. Reduction in Kv Current Enhances the Temporal Dispersion of the Action Potential in Diabetic Myocytes: Insights From a Novel Repolarization Algorithm. J Am Heart Assoc. 2016 Feb 19;5(2). PMID: 26896476.
  • Sorrentino A, Signore S, Qanud K, Borghetti G, Meo M, Cannata A, Zhou Y, Wybieralska E, Luciani M, Kannappan R, Zhang E, Matsuda A, Webster A, Cimini M, Kertowidjojo E, D'Alessandro DA, Wunimenghe O, Michler RE, Royer C, Goichberg P, Leri A, Barrett EG, Anversa P, Hintze TH, Rota M. Myocyte repolarization modulates myocardial function in aging dogs. Am J Physiol Heart Circ Physiol. 2016 Apr 1;310(7):H873-90. PMID: 26801307.
  • Goichberg P, Kannappan R, Cimini M, Bai Y, Sanada F, Sorrentino A, Signore S, Kajstura J, Rota M, Anversa P, Leri A. Age-associated defects in EphA2 signaling impair the migration of human cardiac progenitor cells. Circulation. 2013 Nov 12;128(20):2211-23. PMID: 24141256.
  • Signore S, Sorrentino A, Borghetti G, Cannata A, Meo M, Zhou Y, Kannappan R, Pasqualini F, O'Malley H, Sundman M, Tsigkas N, Zhang E, Arranto C, Mangiaracina C, Isobe K, Sena BF, Kim J, Goichberg P, Nahrendorf M, Isom LL, Leri A, Anversa P, Rota M. Late Na(+) current and protracted electrical recovery are critical determinants of the aging myopathy. Nat Commun. 2015 Nov 6;6:8803. PubMed PMID: 26541940.
  • Signore S, Sorrentino A, Ferreira-Martins J, Kannappan R, Shafaie M, Del Ben F, Isobe K, Arranto C, Wybieralska E, Webster A, Sanada F, Ogórek B, Zheng H, Liu X, Del Monte F, D'Alessandro DA, Wunimenghe O, Michler RE, Hosoda T, Goichberg P, Leri A, Kajstura J, Anversa P, Rota M. Response to letter regarding article "inositol 1,4,5-trisphosphate receptors and human left ventricular myocytes". Circulation. 2014 May 27;129(21):e510- 1.
  • D'Amario D, Leone AM, Iaconelli A, Luciani N, Gaudino M, Kannappan R, Manchi M, Severino A, Shin SH, Graziani F, Biasillo G, Macchione A, Smaldone C, De Maria GL, Cellini C, Siracusano A, Ottaviani L, Massetti M, Goichberg P, Leri A, Anversa P, Crea F. Response to letter regarding article “Growth properties of cardiac stem cells are a novel biomarker of patients' outcome after coronary bypass surgery”. Circulation. 2014 Sep 23;130(13):e118- 9.
  • D'Amario D, Leone AM, Iaconelli A, Luciani N, Gaudino M, Kannappan R, Manchi M, Severino A, Shin SH, Graziani F, Biasillo G, Macchione A, Smaldone C, De Maria GL, Cellini C, Siracusano A, Ottaviani L, Massetti M, Goichberg P, Leri A, Anversa P, Crea F. Growth properties of cardiac stem cells are a novel biomarker of patients' outcome after coronary bypass surgery. Circulation. 2014 Jan 14;129(2):157-72.

Academic Distinctions and Professional Societies

  • Gold Medal, JSS College of Pharmacy, Ooty, India, for acquiring highest score in Master of Pharmacy (Pharmaceutical Biotechnology) for the year 2000
  • Honors Scholarship from Ministry of Education, Culture, Sports, Science, and Technology of Japan during Ph.D. course, 2004-2006
  • AIEJ scholarship from the Association of International Education, Japan, during Ph.D. course, 2006-2007
  • Travel Award from American Heart Association for presenting a poster at the Basic Cardiovascular Sciences (BCVS) 2012 scientific sessions, New Orleans, LA
  • Best of AHA Specialty Conferences: Top 10% of the abstracts at American Heart Association's Specialty Conferences 2012 Scientific Sessions, Los Angeles, CA
  • Professional Member of American Heart Association Society since 2014